Week 16 of the 2025-26 NFL season kicks off with an NFC West battle for the division lead, as the Seattle Seahawks host the Los Angeles Rams on Thursday Night Football. These two teams played a month ago and LA won at home by two points.  

Last week, the Rams (11-3) won a shootout against the desperate, but talented Detroit Lions. However, coming into this TNF game, there’s a chance that the Rams play without Davante Adams who injured his hamstring last Sunday. He’s become a primary weapon for this passing offense, especially in the red zone.

Week 15 saw the Seahawks hang on at home to beat the visiting Colts and 44-year-old Philip Rivers. Seattle was in a fight all game long but persevered in the end to win their fourth straight game. It was a much harder game than their Week 14 blowout win over the Falcons by the score of 37-9. Week 13 also saw them blank the Vikings 26-0.

The winner of this game will not only be in the driver’s seat for the NFC West division, but they will also have the inside track for the top seed in the NFC and make the entire road to the Super Bowl go through their home stadium.

With that said, let’s dive into the Los Angeles Rams vs. Seattle Seahawks Week 16 matchup, take a look at the latest NFL betting odds and trends between these two teams, and make our Thursday Night Football predictions.

What Channel Is Thursday Night Football On?

• Thursday Night Football Channel: Amazon Prime Video
• Thursday Night Football Time: 8:15 p.m. ET
• Thursday Night Football Announcers: Al Michaels and Kirk Herbstreit

The Los Angeles Rams vs. Seattle Seahawks will kick off at 8:15pm ET live from Lumen Field in Seattle, WA.

Thursday Night Football Odds

The following Thursday Night Football odds are courtesy of ScoresandStats:

Keep an eye on the latest NFL odds for TNF and monitor how the lines change throughout the week.

The Week 16 Thursday Night Football odds first opened with the Seattle Seahawks as the Underdog at +1.5 points and a +100 moneyline. That spread jumped to +2.5 points before eventually shifting during the season, especially December.

While the Los Angeles Rams initially opened as the favorite, they ended up dropping from -145 to -110 and getting 1.5 points. The top sports betting sites have bounced back and forth between which team is listed as the favorite. Currently, most sportsbooks have these teams as a Pick.

So, depending on which team you think will win, you might want to shop around for the best odds to get points and/or a better payout. The Total opened at 46.5 points and has slowly fallen to the current Over/Under of 44 points.

Last week, we fell short just like the Buccaneers did when they dropped a home game against the lowly Falcons. Baker and company let us down and we’re now sitting at 7-7 on the season with our TNF picks, not including Thanksgiving.

If you need additional in-depth NFL predictions for the Thursday Night Football games, then check out the industry’s best handicapping membership for free. These fantastic handicappers boast of numerous picks for this Week 16 TNF matchup and the rest of the weekend, as well.

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Thursday Night Football Betting Trends

The following Thursday Night Football betting trends include data from last season:

Los Angeles Rams Betting Trends

• 8-1 SU in last nine games
• 10-0 SU in last 10 December games
• 6-1 SU in last seven NFC games
• 7-2 ATS in last nine games
• 11-2 ATS in last 13 road games
• Over is 4-1 in last five NFC West games

Seattle Seahawks Betting Trends

• 8-1 SU in last nine games
• 5-1 SU in last six games
• 6-2 SU in last eight NFC West games
• 7-2 ATS in last nine games
• 5-0 ATS in last five NFC games
• Under is 4-2 in last six Week 16 games

Thursday Night Football Matchup

These two NFL teams have played against each other 56 times and the series is tied at 28 wins apiece. The Los Angeles Rams have won four of the last five games, which includes taking down the Seahawks on Nov. 16 by the score of 21-19.

Furthermore, the Rams are 8-2 ATS in their last 10 games against the Seahawks and 5-0 ATS in their last five games at Seattle. The Under is 5-1 in the last six games between these two divisional rivals.

Thursday Night Football Predictions

Let’s take a look at each team in the Thursday Night Football game this week, and make our NFL picks for the winner: 

Los Angeles Rams Thursday Night Football

The Rams are 4-1 in their last five games with some big wins over NFC teams. After defeating the Seahawks, LA also took down the Bucs, Cardinals and Lions. Yet, that lone loss was a surprise meltdown at Carolina, which shocked the league.

Since then, the Rams have put up 86 points over two games and seem unstoppable on the offensive side of the ball. Matthew Stafford has this offense sitting at no.2 in scoring (30.0 ppg), total yards (383.6 ypg), and passing yards (257.1 ypg). From there, the Rams also have the no.8 rushing attack at 126.4 ypg.

In the first matchup between these teams, Stafford threw for only 130 yards since the Rams defense forced four interceptions. LA finished with just 249 total yards, which was the lowest mark of the season.

I don’t expect either scenario to happen again. Instead, I expect more of a competitive matchup throughout instead of Seattle making a mad dash to come back in the fourth quarter.

The weather should be wonderful for a night game in Seattle, but the 12^th man is going to be raucous, which might create some issues for this Rams offensive line that allows the second lowest sack rate in the NFL.

Seattle Seahawks Thursday Night Football

The Seahawks are 5-2 at home, 6-3 in the NFC, but just 2-2 in divisional games compared to 9-1 in non-divisional matchups. They’ve dropped matchups against the Rams and 49ers who seem to have Seattle’s number each year.

Nevertheless, Seattle is a solid football team on both sides of the ball. As they’re a Top 10 team in many major offensive categories including scoring (28.9 ppg), yards (350.6 ypg), and passing yards (237.6 ypg).

In their first matchup, which came last month, Darnold threw for 279 yards in addition to four INTs. Unfortunately, they came up short at LA when they tried for a long FG at the end of the game to pull off the come-from-behind win.

This week, I expect a better performance from the Seahawks. Darnold has thrown 8 TDs to just 3 INTs in home games this season. He has a 100.7 rating and 1,500 passing yards in seven games. Darnold has been far more efficient at home with just three interceptions compared to eight on the road.

The Rams feature the no.9 run defense (101.1 ypg) but give up 219.7 passing ypg which is 19^th in the NFL. Last week, the Rams gave up 338 yards to Jared Goff in a shootout. Considering Darnold threw for 279 in their first game, I like Seattle’s passing attack in this game.

Who Is Winning Thursday Night Football?

The Rams were fortunate to win the first matchup this season as Seattle was unable to connect on a game-winning field goal. And, this was in spite of the Rams forcing four INTs.

I think Seattle gets revenge this week, especially since Adams could miss this matchup. Seattle’s defense is a Top 10 unit in all major categories. They will make Stafford’s night tough. Additionally, they rank no.3 against the run as Seattle gives up only 91.6 ypg.

This game will come down to self-inflicted wounds in the form of penalties and turnovers. It’s hard to imagine that Seattle will duplicate their failures from the first matchup.

Without Adams, I think Seattle nullifies Nacua and makes it harder for Stafford to pick up chunk plays. From there, they will stuff Williams and Corum for minimal gains. Take Seattle to win the game and cover any spread at 2.5 points or less.

I also like the Under for this matchup. It’s gone 5-1 in the last six head-to-head meetings. Additionally, these two teams combine to allow 35.9 ppg. Over their last 10 meetings, these teams have allowed a total of 42.5 ppg.

Bet: Seattle Seahawks (-110), Seahawks Pick (-110), Under 44 points (-110)

Thursday Night Football Prop Bets

Let’s take a look at some of the best Player props and Game for this Thursday Night Football matchup:

Sam Darnold Passing Yards

• Over 232.5 yards (-110)
• Under 232.5 yards (-110)

For the season. Sam Darnold is averaging 245.2 passing yards per game. The Rams allow 219.7 passing ypg through 14 games so far.

Darnold has gone over this mark in nine of his 14 starts on the season, including two games in a row. Despite throwing four INTs, Darnold finished with 279 passing yards against the Rams last month. I like for Seattle’s QB to surpass this mark with ease.

Bet: Over 232.5 yards (-110)

Matthew Stafford Touchdown Passes

• Over 1.5 TDs (-110)
• Under 1.5 TDs (-110)

Matthew Stafford is having an MVP season with 37 TDs to just 5 INTs. He’s thrown for two or more TDs in 12 of his 14 starts so far. Against Seattle last month, he tossed two TDs. In fact, Stafford has thrown for at least two touchdowns in eight straight games with a total of 25 TDs over that span. Take the Over for this one, as well.

Bet: Over 1.5 TDs (-110)

Kyren Williams Rushing Yards

• Over 55.5 yards (-110)
• Under 55.5 yards (-110)

Kyren Williams is averaging 73.6 rushing yards per game, and has gone for over 55 yards in 11 of 14 starts. In those three games where he didn’t get at least 55 yards, Williams averaged 50 ypg with a 46-yard performance as his lowest tally.

Against Seattle on November 16, Williams finished with 91 yards on 12 carries. I don’t see a 7.6 ypg average for this matchup. But I do see at least 15 carries for over 60 rushing yards in this TNF game.

Bet: Over 55.5 yards (-110)

Best Bets For Thursday Night Football

The following is our picks as the best bets for Thursday Night Football:

• Seattle Seahawks (-110)
• Seattle Seahawks Pick (-110)
• Matthew Stafford Over 1.5 TD passes (-110)

Seattle is 5-2 at home and highly motivated to avenge their loss to the Rams five weeks ago. I like the Seahawks in this TNF matchup as they’re a difficult team to beat at home. Furthermore, they have a Top 10 offense and defense, which will be tough for the Rams to stop.

Let’s not forget that the Rams only won by 2 points last month, and that was after they forced four INTs on Darnold. Yet, Seattle almost won but their game-winning FG came up short.

Even with backing Seattle to win, I fully expect Stafford to continue his MVP caliber season. He will do that by throwing for at least two touchdowns, which will be his 9^th game in a row accomplishing that and the 13^th time in 15 starts this season.

If you want to add all three of these Week 16 TNF bets to a parlay card, then you would win $595.79 on a $100 wager. That’s almost a 6X return on investment. Check out our best NFL parlay of the week for more exciting multi-wager action. And, if you want even more parlays, then take a look at our best College parlay of the week.

Thursday Night Football Schedule