With four weeks left in the 2025-26 NFL regular season, all 32 NFL Teams will be in action. That means there are no teams on bye and no room for mistakes as Playoff hopes are on the line. And, there are a number of key divisional games that could impact postseason chances.

Week 15 starts off with a Thursday Night Football divisional showdown between the Atlanta Falcons and the Tampa Bay Buccaneers. Both teams are expected to compete for the NFC South title.

Other notable divisional games are the Los Angeles Chargers vs. Kansas City Chiefs, Buffalo Bills vs. New England Patriots, Baltimore Ravens vs. Cincinnati Bengals and Washington Commanders vs. New York Giants.

We’ll also see some crucial gridiron battles that could decide the pecking order within each conference. Perhaps, the best game of the week will be the Los Angeles Rams hosting the Detroit Lions with both teams looking to claim the top spot in the NFC Conference.

Without any further delay, let’s take a look at the NFL Week 15 odds and make our early Week 15 picks. There’s no shame in getting your Week 15 NFL bets in early as there is some value on the boards.

NFL Week 15 Schedule

NFL Week 15 Odds

The NFL odds for Week 15 sees some big disparity in several matchups. The largest Week 15 favorite at sports betting sites is the Philadelphia Eagles. They’re favored by 10.5 points over the Raiders and have a -520 moneyline.

The biggest road favorite of the week is a tie between the Bills at Patriots and Commanders at Giants. Both Buffalo and Washington are favored by 4.5 points in their respective matchups.

The highest Total of Week 15 goes to the Ravens vs. Bengals as they come in at 49.5 total points. The Lions vs. Rams have the second highest Total with a 48.5 over/under. Both games would be optimal for wagering on the best player prop bets.

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NFL Week 15 Predictions

Let’s take a look at the full slate of NFL Week 15 matchups and make our NFL picks for each game.

Atlanta Falcons vs. Tampa Bay Buccaneers Odds

Coming into this season, the Atlanta Falcons and Tampa Bay Buccaneers have played against each other 63 times. The Falcons hold a slight advantage with a 32-31 series record.

Atlanta has also won four of the last five meetings including their last two trips to Tampa Bay. The Falcons swept the Bucs last year.

Atlanta Falcons vs. Tampa Bay Buccaneers Predictions

This Week 15 NFC South battle could decide the division. Sure, there are three games left after this, but it’s the last head-to-head matchup between the two teams that should be fighting for this divisional crown.

I’m a believer in the Falcons this season and think they have a shot to upstage the Bucs. However, I see Tampa Bay winning at home. But I am taking the Falcons to cover the points as this offense should be able to put up points. However, they might have a hard time slowing down Mayfield and company.

Bet: Tampa Bay Buccaneers (-225), Falcons +5.5 (-110)

Las Vegas Raiders vs. Philadelphia Eagles Odds

With 14 all-time meetings between these two teams, each franchise has won seven games apiece. Their last matchup came in 2021, where the Las Vegas Raiders won 33-22. However, the Philadelphia Eagles have won three of the last four.

Let’s also not forget that the Raiders hold the biggest win in this series when they beat the Eagles in Super Bowl 15.

Las Vegas Raiders vs. Philadelphia Eagles Predictions

This game is a complete and total mismatch. In fact, I wouldn’t be surprised if we see the spread eclipse two touchdowns by time Week 15 rolls around.

The Raiders have no hope of stopping this Philadelphia offense. I expect Saquon Barkley to have a big game and lead the charge. I also expect the Eagles defense to destroy this inferior Las Vegas offense.

This might end up being the biggest lopsided win of the season. The Raiders have no shot at winning in Philly.

Bet: Philadelphia Eagles (-520), Eagles -10.5 (-110)

Los Angeles Chargers vs. Kansas City Chiefs Odds

The Los Angeles Chargers and Kansas City Chiefs have played against each other 130 times coming into the 2025-26 NFL Season. The Chiefs lead the rivalry with a 71-58-1 record.

Kansas City has won seven games in a row over the Chargers. The Chiefs have also won three games in a row at home versus LA. The Chargers haven’t won in KC since 2021.

Los Angeles Chargers vs. Kansas City Chiefs Predictions

If this AFC West game was in Los Angeles, then I would give the Chargers more of a chance at winning. However, in Kansas City during December, that just sounds like the perfect environment for Patrick Mahomes and company to win this crucial divisional matchup.

I expect the Chargers to play tough but fade late in the game as they have a number of times before versus the Chiefs. I also see KC locking up the division with this victory as they would hold most tie breakers over LA and Denver.

As for the Chargers, a tough loss might stop them from winning the division but they should still be able to rebound and make a push for one of the three Wild Card spots.

Bet: Kansas City Chiefs (-195), Chiefs -4.5 (-110)

Cleveland Browns vs. Chicago Bears Odds

After 18 all-time meetings, the Cleveland Browns hold the advantage with an 11-7 record. The Browns have also won two games in a row versus the Chicago Bears. Their last meeting came in 2023, where Cleveland won at home 20-17.

However, Chicago is 5-2 at home against the Browns all-time. The Bears have won four in a row at home versus Cleveland.

Cleveland Browns vs. Chicago Bears Predictions

Like the Raiders vs. Eagles, I see this being another lopsided matchup. Sure, the Browns will have a better defense which will make them more challenging, but their offense is dreadful.

The Bears will be in the thick of things as they’re fighting for a Wild Card spot. I believe Chicago is going to be much better than they have been over the last few seasons and Caleb Williams will shine in this new offense.

Look for Chicago’s defense to lead the way as they harass whichever QB that Cleveland trots out there. Offensively, Chicago will finally crack the Browns’ tough defense and pull away late in the game. Skip the points as it could go either way. Yet, I do like the Under and the Bears in this one.

Bet: Chicago Bears (-295), Under 42.5 (-110)

Baltimore Ravens vs. Cincinnati Bengals Odds

Coming into this season, these two teams have played against each other 59 times. So, these stats don’t include their Thanksgiving meeting in Week 13.

The Baltimore Ravens hold the advantage with a 32-27 record. They also have won four games in a row over the Cincinnati Bengals. Baltimore has won two games in a row at Cincy including last year’s Overtime thriller.

Baltimore Ravens vs. Cincinnati Bengals Predictions

This AFC North clash is a rematch of their Thanksgiving Night battle, which should be epic. In fact, both games should be thrilling as these two teams typically put on a show every time they play against each other.

Last year, these two teams combined for an average of 70 points per game in both contests. I see them easily surpassing 50 points in this matchup especially since the Bengals don’t have a good defense.

I gave Baltimore the edge on Thanksgiving, so let’s take Joe Burrow and this offense to pick up a huge victory that keeps them in the hunt for the division title. The Bengals kick a field goal to win this game in a Week 15 thriller.

Bet: Cincinnati Bengals (+110), Bengals +2.5 (-110), Over 49.5 (-110)

New York Jets vs. Jacksonville Jaguars Odds

After 18 all-time matchups, each team has won nine games apiece. Additionally, these two teams have alternated between wins over the last four meetings.

Their most recent meeting came last year, and the New York Jets won 32-25 on the road. The Jacksonville Jaguars are 5-2 all-time at home versus the Jets and have won two of their last three games at home.

New York Jets vs. Jacksonville Jaguars Predictions

This game will be the toilet bowl of the week. Both teams should be long out of hunt for a Playoff spot and well below a .500 record.

In reality, it will come down to which team is tanking harder and trying to get a high draft pick. I see that being the Jets as they go for a franchise QB at the top of the 2026 NFL Draft.

Take the Jaguars to win a stinker at home as they outduel an equally bad Jets team in front of a half empty stadium.

Bet: Jacksonville Jaguars (-198), Jaguars -4.5 (-110)

Buffalo Bills vs. New England Patriots Odds

Coming into this season, the New England Patriots hold a commanding lead with a 79-51-1 record. However, the Buffalo Bills have gone 8-3 in the last 11 matchups.

The Patriots have won their last two meetings at home over the Bills. Yet, the matchup last year was in the final week when Buffalo rested their starters.

Buffalo Bills vs. New England Patriots Predictions

I believe the Buffalo Bills will have wrapped up the AFC East before Week 15. If not, then beating the Patriots on the road will seal the deal. I like the pieces that New England is putting together but they’re still a year away from being a threat to Buffalo in the division.

The Bills will be aiming for the top spot in the AFC Conference, which won’t be easy with the Chiefs most likely snagging that honor once again.

As for this matchup, I expect a close game for the first half. Then, Josh Allen and the Bills offense will step on the gas and pull away by the fourth quarter. Buffalo’s defense will get some timely stops and maybe a turnover or two, which leads Buffalo to a win by at least a touchdown.

I also like the Over, as I can easily see the final score at least 28-21 or 27-20 score in favor of the Bills.

Bet: Buffalo Bills (-205), Bills -4.5 (-110), Over 46.5 (-110)

Arizona Cardinals vs. Houston Texans Odds

With just six meetings between these franchises, each team has won three games apiece. They last played in 2023, and it was the Houston Texans that won. In fact, Houston is 3-0 at home against the Arizona Cardinals, while the latter is perfect at home. Neither team has a road win in this series.

Arizona Cardinals vs. Houston Texans Predictions

Like the Chiefs and Bills, the Houston Texans should have locked up or will lock up the AFC South in Week 15. They have the benefit of playing in the worst division in football this season as the Jags, Titans and Colts should all finish with losing records.

With that said, Arizona is going to be a good team this year. And, while I don’t see them winning the NFC West, I do believe that the Cardinals can remain in the hunt for a Wild Card until the final week of the season. With a little luck, we could see Arizona in the Playoffs.

As for this matchup, Houston will be too tough at home for the Cardinals to overcome. I like this Texans defense a lot and I think they will smother Arizona’s offense.

Offensively, the Texans will run on Arizona and set up the play-action to Collins, which should result in some big plays. Take Houston to win and cover the spread.

Bet: Houston Texans (-130), Texans -2.5 (-110)

Washington Commanders vs. New York Giants Odds

These two divisional rivals have played against each other a whopping 186 times prior to this season. The New York Giants hold a large lead with a 108-73-5 record. However, the Washington Commanders won both meetings last year. Yet, those games were both decided by five points or less.

The Giants are 3-2-1 in their last six games at home versus Washington but have an all-time home record of 58-32-3.

Washington Commanders vs. New York Giants Predictions

Even if the Giants are out of the running in the NFC East, I still expect them to play Washington tough in Week 15. While the Commanders will be jockeying for Playoff positioning, the Giants will be fighting to keep their head coach’s job.

At some point, the futility in New York will cost Brian Daboll his job and I see that being this year. He was lucky to keep his position after last season. After this year, I see the Giants cleaning house and also getting rid of QB Russell Wilson.

Washington wins a tight football game due to their franchise QB making plays with his legs. The Commanders defense will get a few late-game turnovers and beat the Giants on the road. I’m avoiding the spread and Total for this game as we have no idea how bad this Giants offense might be.

Bet: Washington Commanders (-195)

Indianapolis Colts vs. Seattle Seahawks Odds

With 13 all-time meetings in this rivalry, it’s the Indianapolis Colts that hold a slight lead with a 7-6 record. However, the Seattle Seahawks have won two games in a row over Indy including their last meeting which took place in 2021. The Seahawks have also won three of their last four games at home versus Indy.

Indianapolis Colts vs. Seattle Seahawks Predictions

This game will be an interesting matchup. We have two teams clearly a step below the Playoff contenders. However, they both will be heading in different directions.

The Seahawks have a chance to finish above .500 on the season but I don’t see that for the Colts. Despite their talent, Indy’s QB situation will plague them all year long. While Seattle’s Sam Darnold isn’t going to torch the league this year, he will provide the Seahawks with winning QB play.

At home, you have to like Seattle to win this game. However, I don’t trust them to cover the spread. The smart play is to take Seattle’s moneyline and run away with your winnings.

Bet: Seattle Seahawks (-175)

Carolina Panthers vs. New Orleans Saints Odds

Entering the season, the New Orleans Saints hold a slight advantage with a 32-29 record. The Saints have also won three of the last four meetings against the Carolina Panthers. The Saints have taken five of their last six home games versus the Panthers. Carolina hasn’t won at New Orleans since the final week of the 2022-23 NFL season.

Carolina Panthers vs. New Orleans Saints Predictions

Although I believe the Panthers will be an improved team this year, I still see them finishing behind the Bucs and Falcons. As for the Saints, they will be one of the worst teams in the NFL this season, if not the worse.

I love the value here for Carolina. Not only will they cover the spread, but they will win this game in convincing fashion. The Panthers might still be mathematically alive for the Playoffs with this win, but the Saints will be in full tank mode by now as they look for a franchise QB in the 2026 NFL Draft like the Jets.

Take the Panthers offense to steamroll a lifeless New Orleans team as they win by at least four points or more on the road.

Bet: Carolina Panthers (-122), Panthers -1.5(-110)

Green Bay Packers vs. Denver Broncos Odds

With 16 all-time meetings between these two franchises, it’s the Denver Broncos with a very slight advantage at 8-7-1. Their last matchup came in 2023, where Denver won at home. However, the Green Bay Packers have won four of the last six meetings.

Denver is 8-1 all-time in home games against the Packers and have won two in a row. Green Bay has not won at Denver since 2007.

Green Bay Packers vs. Denver Broncos Predictions

The Lions vs. Rams might get the top billing for Week 15, but this has to be in the running for the co-main event. Sure, the Chargers vs. Chiefs and Ravens vs. Bengals will both be strong matchups, but I really like this Packers vs. Broncos contest.

Both teams will fall short of winning their respective divisions, yet I see them both contending for the 5^th seeds in their respective conferences.

This Week 15 game should go to the Broncos since they’re at home and the Packers aren’t used to playing at that elevation. Plus, Denver’s defense will stifle this Green Bay offense which will allow Bo Nix and the Broncos’ offense to have more possessions and better field position.

We might not get a lot of points in this game, but it will still be an entertaining one where the Broncos scrape and claw their way to victory.

Bet: Denver Broncos (-120), Broncos -1.5 (-110)

Tennessee Titans vs. San Francisco 49ers Odds

The San Francisco 49ers hold the lead in this series with a 9-6 record. Yet, it’s the Tennessee Titans that won their most recent matchup, which took place in 2021.

The 49ers are just 4-3 in home matchups versus the Titans. But did win the last time these two teams played in the Bay Area (2017).

Tennessee Titans vs. San Francisco 49ers Predictions

This game is much needed for the San Francisco 49ers as they try to pull in some victories late in the season to fight for a Wild Card spot. I don’t want to say this is a Bye Week for the 49ers, but it’s as close as it gets.

The Titans will be lucky to sniff four wins on the season. And, though the 49ers won’t be as good as they have been the last handful of years, they are still far better than Tennessee is.

I don’t see San Francisco making the Playoffs this year, even with a blowout win at home over the Titans in Week 15. I think they fall short. With that said, I’m comfortable taking the 49ers up to 9.5 points in this matchup.

Bet: San Francisco 49ers (-325), 49ers -7.5 (-110)

Detroit Lions vs. Los Angeles Rams Odds

After 89 games played between these two franchises, the Los Angeles Rams hold a slight lead with a 45-43-1 record. However, it’s the Detroit Lions that have won two in a row over the Rams including both meetings in 2024.

The Rams have gone 6-1 in their last seven home games versus the Lions including winning three in a row. The last time these two teams played in Los Angeles was in 2021.

Detroit Lions vs. Los Angeles Rams Predictions

By Week 15, we should see both teams leading their respective divisions. The Detroit Lions will win the NFC North once again, while the Los Angeles Rams appear to be the best in the NFC West. So, this game will be huge for Conference seeding and tiebreakers at the end of the year.

I really like what the Rams have with this team. However, it’s one thing to beat up on their division, it’s another to beat an elite team like Detroit.

Until the Rams show us how good they are this year, and beat elite teams like the Lions and Eagles in the NFC, you have to side with the visiting team in this matchup.

We know that Detroit will be great once again. In fact, they should be even better than last year because they have all of their injured defenders back and healthy.

The Rams have some tough games prior to Thanksgiving, so we’ll get a better idea of how strong they will be in the NFC. For now, the smart bet is on the Lions. However, if the Rams come out and steamroll through their schedule, then pivot to LA for this matchup.

Bet: Detroit Lions (-118), Lions -1.5 (-110)

Minnesota Vikings vs. Dallas Cowboys Odds

Coming into this year, the Dallas Cowboys hold the lead in this series with a 19-15 record. These teams last played in 2022, and Dallas won that matchup at Minnesota. In fact, Dallas has won five of the last six head-to-head meetings, including three in a row.

With that said, the Minnesota Vikings have gone 8-4 in their last 12 trips to Dallas. They won the last game in “The Big D” (2019), by the score of 28-24.

Minnesota Vikings vs. Dallas Cowboys Predictions

If you have checked out some of our other breakdowns of these NFL futures bets for each week, you would have seen that I am not high on Minnesota this year. In fact, I don’t see them making the Playoffs like they did last year. I’m not a big believer in JJ McCarthy and I see this secondary being a weak link.

With that said, I’m not a big believer in Dallas either. However, I feel that this matchup suits the Cowboys. Dak Prescott will lead the Dallas passing attack to a big game and at least 24 points, as Pickens and Lamb torch Minnesota’s secondary.

On the other side, the Cowboys defense will make McCarthy’s life miserable for three hours. Micah Parsons will be in the backfield so much that Minnesota will think he’s their starting running back.

Take Dallas at home to pull off the Sunday Night Football upset and keep their Playoff hopes alive.

Bet: Dallas Cowboys (+102), Cowboys +1.5 (-110)

Miami Dolphins vs. Pittsburgh Steelers Odds

Only one win separates these two teams in their previous 29 meetings. The Pittsburgh Steelers hold a 15-14 lead over the Miami Dolphins, but it’s the latter that won their last meeting which came in 2022.

Pittsburgh is 9-4 all-time at home against Miami. The Steelers have won four of the last five games in the “Steel City,” including two in a row.

Miami Dolphins vs. Pittsburgh Steelers Predictions

This is going to be a crucial AFC matchup between two teams fighting for that final Wild Card spot. While both could end up missing out altogether, I do think that Pittsburgh has the edge here.

The Steelers have the better defense and Jalen Ramsey will be playing with extra motivation against his former team and the loud mouth Tyreek Hill.

Pittsburgh has the better coaching staff, better defense, and will play a smash mouth style of offense that controls the clock and wears down Miami’s defense by the fourth quarter.

Look for the Steelers to pull away in the fourth quarter. And, if this Monday Night Football game ends up being played in freezing temperatures, then Pittsburgh wins by double digits. So, keep an eye on the weather forecast.

Bet: Pittsburgh Steelers (-135), Steelers -2.5 (-110)

NFL Week 15 Best Bets

The following is our best bets for Week 15:

• Philadelphia Eagles (-520)
• Chicago Bears (-298)
• San Francisco 49ers (-325)
• Dallas Cowboys +1.5 (-115)

All four of these teams are playing at home this week. The Eagles, Bears and 49ers are all favored by at least a touchdown. In the case of Philly, they’re a double-digit home favorite.

They will play three of the five worst teams in the NFL during Week 15. I highly doubt that either of the Raiders, Browns or Titans have more than three wins by this point in the season. Combined, I doubt we see 10 total wins between these three teams.

As for Dallas, that’s the outlier in this parlay. I love this matchup against Minnesota as the Cowboys’ strengths line up well against the Vikings’ weaknesses.

I expect Prescott, Lamb and Pickens to destroy Minnesota’s subpar secondary. I also believe that Dallas’ pass rush will wreak havoc on McCarthy and the Vikings’ offense.

If you want to place all four of these picks into an NFL parlay, then you would win $289 on a $100 wager. That’s a great payout considering you are taking the three biggest favorites of the week.