Broncos vs Cardinals Best Pick, Prediction and Odds

Broncos 3-2 and Cardinals 1-4. Here is where this game stands.

The game

The Broncos visit the Cardinals on Sunday 25 October at 4:05 PM ET.

Last season finished with the Cardinals at 3-14 and the Broncos at 14-3. They did not meet in the data we hold, which starts with the 2025 season.

This season so far

In Week 1 the Broncos lost to the Chiefs 10-31 on the road. In Week 2 the Broncos beat the Jaguars 20-13. In Week 3 the Broncos beat the Rams 30-26. In Week 4 the Broncos lost to the 49ers 14-24 on the road. In Week 5 the Broncos beat the Chargers 23-17 on the road. In Week 1 the Cardinals beat the Chargers 26-14 on the road. In Week 2 the Cardinals lost to the Seahawks 7-31. In Week 3 the Cardinals lost to the 49ers 30-36 on the road. In Week 4 the Cardinals lost to the Giants 24-36 on the road. In Week 5 the Cardinals lost to the Lions 21-45.

The early line

The early line has the Cardinals at +7.5, the median of 3 books. The total is 43.5 across 3 books.

These are look-ahead prices, read 13 Sep 17:10 UTC, and only 3 books were quoting the spread. With the bookmaker margin removed, the moneyline makes the Broncos 74.8% to win. Expect them to move once the weeks in between are played.

Denver Broncos at Arizona Cardinals, Sunday 25 October at 4:05 PM ET. Prices: US sportsbooks via Nucleus, read 13 Sep 17:10 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 7 game: NFL Week 7 odds and predictions.