Patriots 1-1 and Bills 2-0. Here is where this game stands.
The game
The Patriots visit the Bills on Sunday 4 October at 1:00 PM ET. The game is in Buffalo.
Last season finished with the Bills at 12-5 and the Patriots at 14-3. They last met in Week 15 of last season, when the Bills won 35-31 in New England.
This season so far
In Week 1 the Patriots lost to the Seahawks 10-13 on the road. In Week 2 the Patriots beat the Steelers 20-3. In Week 1 the Bills beat the Texans 36-31 on the road. In Week 2 the Bills beat the Lions 41-31.
The early line
The early line has the Bills at -4, the median of 2 books. The total is 49.5 across 2 books.
These are look-ahead prices, read 10 Sep 00:10 UTC, and only 2 books were quoting the spread. With the bookmaker margin removed, the moneyline makes the Bills 61.5% to win. Expect them to move once the weeks in between are played.
New England Patriots at Buffalo Bills, Sunday 4 October at 1:00 PM ET. Prices: US sportsbooks via Nucleus, read 10 Sep 00:10 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 4 game: NFL Week 4 odds and predictions.








