Louisville Cardinals

Louisville football covered the spread in one of its eight 2025 home games, and only one FBS team covered less often at home. Away from home the Cardinals covered three of four and won at Miami as 10.5-point underdogs.

The home number

Louisville finished the 2025 regular season 8-4 straight up and 4-8 against the spread. In front of its own crowd Louisville won five of eight and covered once, the only cover a 41-0 win over Kentucky in the finale. Of the 136 FBS teams, 134 covered a higher share of their home games.

All three home losses came by three points or fewer, all as favorites: 30-27 to Virginia at -6.5, 29-26 to California at -18.5 and -1600, and 20-19 to Clemson at -2.5. Four home wins as favorites of 15.5 points or more all fell short of the line.

On the road

Away, it went 3-1 and covered three. The best of it was a 24-21 win at Miami at +360. One unit on the Cardinals in each road game returned 3.54 units over four; the same stake at home lost 2.84 over six priced games. Across all ten priced games the moneyline finished 0.70 units up.

As a favorite Louisville won seven of ten and covered three. Seven of the 12 games went under the total. The season ended with a 27-22 win over Toledo in the Boca Raton Bowl.

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