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Cienciano host Academia Puerto Cabello at Estadio Inca Garcilaso de la Vega in Cusco on Thursday night, with kickoff set for 10:00 PM ET. This is a Copa Sudamericana Group B match, and it already matters more than a typical early group-stage game. Puerto Cabello come in top of the group on three points after their opening win, while Cienciano sit on one point after drawing their first match. A home win would tighten the group immediately. A road result would give the Venezuelan side real control this early in the stage. The setting matters here too. Cusco is never a neutral kind of trip. Altitude changes the pace of matches, affects recovery, and usually tilts the physical demands toward

San Lorenzo host Deportivo Cuenca at Estadio Pedro Bidegain on Thursday night in a Copa Sudamericana Group D match that already carries real pressure after one round. Cuenca sit top of the group with three points after beating Santos 1-0, while San Lorenzo opened with a 1-1 draw against Deportivo Recoleta. After Santos and Recoleta drew 1-1 on Tuesday, this spot became even more interesting because a home win would put San Lorenzo right back in control of the group race, while a draw would suit Cuenca a lot more than it suits the Argentine side. The recent form is a little mixed on both sides, but in different ways. San Lorenzo are not giving much away, coming off a

Atletico Mineiro host Juventud de las Piedras on Thursday, April 16, 2026, at Arena MRV in Belo Horizonte, with kickoff set for 6:00 PM ET. This is a Copa Sudamericana Group B match, and the pressure is already real for the Brazilian side after a 2-1 loss at Academia Puerto Cabello in their opener. Juventud, meanwhile, opened with a 1-1 draw against Cienciano, so they come in with a point and perhaps a little more room to manage the night carefully. That group-stage context matters. Atletico are sitting bottom of Group B after one round, while Juventud are level on points with Cienciano and above Atletico on the early table. It is still early, obviously, but dropping points at home

Tigre host Macara at Estadio José Dellagiovanna on Thursday, April 16, in Copa Sudamericana group-stage action. Kickoff is listed for 7:00 PM local time in Buenos Aires, and the table already gives this match some real weight. América de Cali sit on four points from two matches, while Tigre and Macara each have one point from one game, so this is not a spot where either side should feel comfortable settling for too little. That context matters for the handicap. Tigre opened the group with a 1-1 draw at Alianza Atlético, then followed it with a 0-0 domestic draw at Atlético Tucumán. Macara started with a respectable 1-1 draw against América de Cali, but they come into Argentina off back-to-back