NFL Week 7 opens and closes with some exciting matchups. The first game of the week is an AFC North battle on Thursday Night Football as the Cincinnati Bengals host the AFC’s no.2 seed – Pittsburgh Steelers.

On Monday Night Football, NFL bettors and fans will be treated to two games as the Tampa Bay Buccaneers head to Motown to take on the Detroit Lions and the Seattle Seahawks host the Houston Texans.  

Only two franchises have a bye this week: the Baltimore Ravens and Buffalo Bills. Both of these AFC Conference powerhouses are among the early betting favorites to win the Super Bowl, but they’re also both grateful for the off week due to each team slumping over the last few weeks.

That means we’ll be treated to 30 NFL teams playing across 15 games from Seattle to the 4^th International Game of the season, which takes place in London.

Without any further delay, let’s take a look at the NFL Week 7 odds and make our early Week 7 picks. There’s no shame in getting your Week 7 NFL bets in early if you can identify value on the boards, which we definitely have!

NFL Week 7 Schedule

NFL Week 7 Odds

An early look at the Week 7 NFL odds provides us with a few betting opportunities at the top sports betting sites. However, before we get into those wagers, let’s take a look at the Week 7 odds as a whole.

This looks like a potentially fun slate of games. We’re still light on divisional matchups this early in the season, but games like Rams-Jaguars, Colts-Chargers, and Commanders-Cowboys have legitimate shootout potential. If you want to find sneaky underdog value, our weekly rundown of NFL underdogs is a great place to start.

With that said, if you are interested in some extra assistance for the NFL season, then check out the industry’s best handicapping membership. Get a Free Trial upon signing up and take advantage of thousands of NFL picks throughout the season.

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NFL Week 7 Predictions

Let’s take a look at the full slate of NFL Week 7 matchups and make our NFL picks for each game.

Pittsburgh Steelers vs. Cincinnati Bengals Odds

The Week 7 schedule begins with an AFC North showdown as the Steelers visit the Bengals on Thursday night. This looked like a fun matchup on paper heading into the season, but Joe Burrow’s turf toe injury has since thwarted Cincinnati’s campaign. The Bengals have dropped 4 straight on the heels of a 2-0 start, though they did look a little better with Joe Flacco under center last week in Green Bay.

Even a 40-year-old Flacco looks like an upgrade over Jake Browning, who was a turnover machine filling in for Burrow. In a losing effort in Week 6, Flacco threw for 219 yards and a couple of touchdowns against a stingy Packers defense in a hostile road environment. Cincy’s offense predictably got off to a slow start, but let’s not forget Flacco was starting after arriving just 6 days earlier via trade from the Cleveland Browns.

The Steelers are off to a tidy 4-1 start with their own aging new QB, Aaron Rodgers. It hasn’t always been pretty, but wins are wins. Through 5 games in the Black & Yellow, the future Hall of Famer has topped 1,000 yards with 10 touchdown passes to just 3 interceptions. Rodgers was efficient in last week’s 23-9 win over the Browns, going 21-for-30 through the air with a couple of TDs and no turnovers. He’s already formed a prolific partnership with DK Metcalf, who’s scored a receiving touchdown in each of the Steelers’ last 4 games.

It’s not surprising to see the Steelers listed as road favorites amid the Bengals’ struggles, but 5.5 points is a lot to lay for a visiting divisional rival. At first glance, the under on 43.5 points looks like the play, even if Cincinnati’s defense has been wildly porous through the season’s first 6 games.

Pittsburgh Steelers vs. Cincinnati Bengals Predictions

Spread: Bengals +5.5 (-110)
This bet isn’t for the risk-averse, but I do expect the Bengals’ offense to start to click as Flacco continues to find his footing. The Steelers have also been vulnerable against the run, so perhaps Chase Brown will finally get it going in the midst of a woeful start to his 2025.

Total: Under 43.5 (-110)
Neither team runs its offense at a particularly fast pace. While we do have a couple of capable veteran QBs under center, Thursday night games tend to be uglier, lower-scoring affairs. Mix in the AFC North rivalry and you’ve got a solid recipe for the under on 43.5 points.

Moneyline: Bengals ML (+220)
Call me crazy, but I doubt the Bengals will go winless for as long as Burrow is sidelined. The trade for Flacco was a smart one, and he started to get things going with Ja’Marr Chase and Tee Higgins as his team debut went on last week. Pittsburgh’s defense hasn’t been as stingy as expected, and you won’t often see a team listed as a +220 underdog on their home field.

Bet: Bengals ML (+220), Bengals +5.5 (-110), Under 43.5 (-110)

Los Angeles Rams vs. Jacksonville Jaguars Odds

Week 7’s Sunday docket kicks off bright and early from London as the Jacksonville Jaguars “host” the LA Rams in another international matchup. Jacksonville is looking to bounce back after a narrow defeat to the Seahawks, while the Rams head overseas following a much-needed win over a severely shorthanded version of the Ravens. Both offenses have shown flashes of explosiveness but have also struggled to sustain drives.

The big news out of Los Angeles is that Puka Nacua is likely to miss this game after injuring his ankle in Baltimore. This is a potentially monumental blow considering Puka has been the NFL’s most prolific pass-catcher so far this season. Through 6 games, Nacua has caught 54 passes for 616 yards and a couple of TDs. Those are eye-popping numbers, especially considering he totaled just a couple of catches for 28 yards as a result of the injury last week.

Without Puka, expect a heavy dosage of the Matthew Stafford-to-Davante Adams connection. Adams has been no slouch in his first year in LA, with 26 receptions for 396 yards and 3 touchdowns. The Rams will also have to rely more heavily on their secondary targets, including Tutu Atwell and Jordan Whittington. Kyren Williams – who has yet to top 100 rushing yards in a single game this season – will also be a focal point with Nacua’s dynamism missing from the lineup.

The Jags, meanwhile, are off to a solid 4-2 start under first-year head coach Liam Coen. They followed up a dramatic Monday Night Football victory over the mighty Chiefs with a letdown showing last week against the Seahawks, however. While Trevor Lawrence threw for 258 yards and a couple of touchdowns, it feels like Jacksonville’s offense is still leaving points on the table.

It was nice to see Brian Thomas Jr. finally get going, however. After a quiet start to the season, the second-year playmaker caught a season-high 8 passes for 90 yards and his first score of the campaign. The next order of business should be to get Travis Hunter more involved. Last year’s Heisman Trophy winner has just 20 catches for 197 yards through his first 6 NFL outings. 

While the weird schedule could throw off both offenses, I do think this game has some high-scoring potential. The Rams mustered just 17 points against a ragged Ravens defense last week, and perhaps they simply took Baltimore too lightly. I expect LA to be more focused heading into this one, and Sean McVay will know how to exploit the Jags’ defensive weaknesses even without Nacua’s services.

Los Angeles Rams vs. Jacksonville Jaguars Predictions

Spread: Rams -3 (-115)
Los Angeles’ offense has a higher ceiling, and Stafford’s experience gives them a major edge against a young Jacksonville secondary. Expect the Rams to pull away in the second half.

Total: Over 46.5 (-105)
Both offenses have enough firepower to put points on the board. The Rams should feature a lot of Adams and Williams without Puka, while the Jags should bounce back here against an LA defense that could be a bit road-weary.

Moneyline: Rams ML (-166)
The Rams are the more consistent team and travel better than most. With McVay scripting early success, this should be a steady, professional win.

Bet: Rams ML (-166), Rams -3 (-115), Over 46.5 (-105)

New England Patriots vs. Tennessee Titans Odds

The New England Patriots head to Nashville after impressive back-to-back road wins over Buffalo and New Orleans, while the Tennessee Titans limp into this one trying to find an offensive rhythm. The Titans are off to a 1-5 start, and last week’s loss to Las Vegas was, apparently, the final straw for head coach Brian Callahan. The Titans fired Callahan after a 4-19 start to his career. Former LA Chargers offensive coordinator Mike McCoy will take over as the interim boss starting this weekend.

The Patriots are off to a 4-2 start, thanks in no small part to the emergence of second-year QB Drake Maye. At long last, it looks like the Pats have finally found Tom Brady’s successor. Through 6 games, Maye has completed better than 73 percent of his throws for 1,522 yards and 10 touchdowns to just 2 interceptions. Maye has also added a couple of rushing touchdowns, matching last season’s total output in less than half as many appearances.

The scheduling gods haven’t done New England any favors, as this will be their third consecutive game away from Gillette Stadium. On the bright side, they’ll get to take on the league’s worst team in this one, which explains why they’re favored by a touchdown on the road.

I’m not sure what’s left to say of the Titans, who are awfully lucky to have their 1 win on the year. The writing was on the wall for Callahan, and it’ll be interesting to see how McCoy changes the offensive game plan for former No. 1 overall pick, Cam Ward. Ward has said he prefers to run a fast, up-tempo style, yet the Titans employed one of the slowest and least creative offenses in the league under Callahan. Too much Tony Pollard. Way too much Tony Pollard.

Ward doesn’t have great weapons at his disposal, but Calvin Ridley is a proven possession receiver, while rookie Elic Ayomanor has shown flashes as a deep threat. The Titans can also stand to do a better job of using Ward’s athleticism to their advantage. The 23-year-old has just 14 carries for 36 yards on the season, and Tennessee rarely called designed runs for their dynamic rookie. Let’s hope we see Ward use his legs more moving forward.

New England Patriots vs. Tennessee Titans Predictions

Spread: Patriots -7 (-115)
While I’m optimistic the Titans will start to look more like a real NFL franchise under a new head coach, I’ll have to see it before I can believe it. New England is rolling right now. A 7-point spread is a little scary for a road team with a young QB of their own, but I trust Maye to take care of business.

Total: Over 42.5 (-115)
Tennessee’s offense simply can’t be this bad forever, while I think Maye and his gaggle of undervalued receivers will put points on the board against the Titans’ porous defense. This is a sneaky game to shoot for the over on a meager 42.5-point total.

Moneyline: Patriots ML (-355)
No need to galaxy-brain this one, folks.

Bet: Patriots ML (-355), Patriots -7 (-115), Over 42.5 (-115)

Philadelphia Eagles vs. Minnesota Vikings Odds

The struggling Philadelphia Eagles visit the well-rested Minnesota Vikings in what could be one of Week 7’s most entertaining games. The vibes in Philly are dreadful right now despite a 4-2 record and another Super Bowl title just a few months ago. Philadelphia has dropped consecutive games, including a shocking 34-17 setback last Thursday against the New York Football Giants.

The Vikings are fresh off of their bye week, though there are plenty of questions about their starting quarterbacks. JJ McCarthy is reportedly trending in the right direction after suffering a high-ankle sprain back in Week 2, but the team isn’t yet ready to commit to whether he’ll be ready to return to the field this weekend. His backup – ex-Eagle Carson Wentz – is dealing with a shoulder injury. I assume one of the two will be healthy enough to start. If not, we’ll see former University of Minnesota standout Max Brosmer make the first start of his pro career on Sunday.

Needless to say, the odds will shift dramatically in favor of the Eagles if Brosmer winds up taking the field. Philadelphia is tentatively favored by about a field goal on the road here, which is a likely hedge by the sportsbooks. The Vikings’ coaching staff hasn’t disclosed anything publicly about whether McCarthy and/or Wentz will be good to go, but we’ll know more later in the week.

Despite the weird vibes, I have a hard time imagining the Eagles will continue to struggle forever. There’s simply too much talent on both sides of the ball. AJ Brown and DeVonta Smith are both reportedly frustrated by their roles in the offense, while Saquon Barkley hasn’t been able to find his footing on the heels of his record-breaking outburst in 2024. This matchup is a tricky one, however, as the Minnesota defense has been proficient in terms of getting to opposing quarterbacks over the past couple of seasons.

It’s still tough to have much faith in the Vikings to put enough points on the board to outlast the Birds in this one. McCarthy is the unquestioned starter if he’s healthy, but it’s not like he looked good in his 2 games under center to begin the season. I expect the Eagles to generate a consistent enough pass-rush to disrupt the Minnesota offense on Sunday.

Philadelphia Eagles vs. Minnesota Vikings Predictions

Eagles -2.5 (-105)
Philadelphia’s trench advantage and quarterback play make the difference. Hurts’ dual-threat ability has the potential to counteract Minnesota’s blitz looks.

Under 44.5 (-115)
These are two quality defenses going toe-to-toe, while both teams also happen to have major question marks on offense. Give me the under on 44.5.

Eagles ML (-135)
The Eagles are the more complete team and rarely lose when favored by less than a field goal. A narrow but deserved road victory feels likely.

Bet: Eagles ML (-135), Eagles -2.5 (-105), Under 44.5 (-115)

Carolina Panthers vs. New York Jets Odds

Game of the week? No? Okay, then.

The New York Jets are off to an 0-6 start in the first year of the Aaron Glenn Era. Needless to say, things could be going better for Gang Green. The offense wasn’t able to muster much of anything in a gross 13-11 loss to Denver last week in London, but perhaps they’ll find some footing this week against a weaker Carolina defense at home.

Based on the roster, the Jets are too talented to go 0-17. They’re going to win a game at some point, and oddsmakers think this is the week. They’re only 2.5-point home favorites, but they’re favorites nonetheless. One issue is that star wideout Garrett Wilson will be sidelined with a knee injury, which means Justin Fields will need someone to step up for him in the passing game. Rookie tight end Mason Taylor looks like a decent bet to see increased volume, while Josh Reynolds and Allen Lazard may step into bigger roles. Don’t be surprised if Breece Hall plays a bigger role in passing situations, too.

The Carolina Panthers are off to a 3-3 start, thanks, in part, to a soft schedule. The Panthers have rattled off back-to-back close home wins over the Dolphins and Cowboys, who happen to be among the NFL’s leakiest defenses. I still don’t consider Bryce Young to be a starting-level NFL QB, and I think he’s going to struggle in this one against a Jets defense with some formidable names in the front-7. 

On the bright side, Carolina has found a lot of success in the run game thanks to a couple of standout performances from Rico Dowdle, who’s stepped into a starting role with Chuba Hubbard out of late. The former Cowboy has a whopping 53 carries for 389 yards over just the last 2 games with another 7 catches and 84 yards through the air. That said, I expect him to find the sledder a bit tougher in this matchup.

Carolina Panthers vs. New York Jets Predictions

Spread: Jets -2.5 (-105)
It’s not for the faint of heart, but I expect the Jets to finally get into the win column this week. They’ll try to control the tempo with Fields and Hall in the ground game, and I think they’ll find success against a middling Panthers defense.

Total: Under 42.5 (-110)
Points will come at a premium in this one. Young hasn’t been all that great at sustaining drives early in his career, and I’m willing to bet Dowdle’s hot run will come crashing to a halt. If the Jets control the tempo, we’re in for a low-scoring affair.

Moneyline: Jets ML (-150)
J-E-T-S!

Bet: Jets ML (-150), Jets -2.5 (-105), Under 42.5 (-110)

Las Vegas Raiders vs. Kansas City Chiefs Odds

Here we have an old AFC West rivalry that sure looks like a mismatch on paper. The Las Vegas Raiders finally got back into the win column last week, albeit at the expense of the lowly Titans. The Kansas City Chiefs, on the other hand, are winners of 3 of 4 following an uncharacteristic 0-2 start. The Chiefs picked up an impressive win over the Detroit Lions last Sunday night.

The big news out of KC this week is the return of Rashee Rice. The Chiefs’ dynamic receiver missed most of last season with a torn ACL, while he was suspended for the first 6 games of this term. On a team filled with playmakers, Rice is arguably Kansas City’s most potent weapon. In his lone full season in the league, the SMU product caught 79 passes for 938 yards with 7 TDs and helped the Chiefs win Super Bowl 58. 

The 11.5-point spread in this one is awfully large, but it’s probably justified. The Raiders’ offense hasn’t lived up to expectations despite the offseason additions of Ashton Jeanty, Geno Smith, and others. Smith currently leads the NFL in interceptions with 10, and he’s struggled to develop a rapport with Jakobi Meyers. Las Vegas’ best offensive player – Brock Bowers – has also been dealing with a knee injury that’s kept him out of the lineup in back-to-back games. 

Establishing Jeanty early will be the key to whether the Raiders can stay in this game. Las Vegas is just 2-10 in their last 12 trips to Arrowhead Stadium, and I’m not sure the Raiders’ defense will be up to the task of stopping what is now a fully operational Chiefs offense in this one.

Las Vegas Raiders vs. Kansas City Chiefs Predictions

Chiefs -11.5 (-112)
Kansas City’s offense is clicking into gear, and now they get Rashee Rice back into the mix., The Raiders lack the firepower to keep pace. Mahomes should carve them up easily.

Under 45.5 (-112)
The Chiefs could jump out early and cruise, but expect the scoring to taper off as Vegas struggles to contribute.

Chiefs ML (-850)
Kansas City is a parlay anchor this week. There’s no safer straight-up option on the board.

Bet: Chiefs ML (-850), Chiefs -11.5 (-112), Under 45.5 (-112)

Miami Dolphins vs. Cleveland Browns Odds

The Miami Dolphins make the trip north to Cleveland in search of their second win after another heartbreaking loss, while the Browns return home trying to get anything going offensively. Miami fell 29–27 to the Chargers in Week 6, a game that saw Tua Tagovailoa and De’Von Achane carry the offense, but the defense faltered late. The Cleveland Browns, on the other hand, continued its offensive struggles in a 23–9 defeat to the Steelers, managing just 65 rushing yards and failing to score a touchdown for the third time this season.

For the Browns, rookie quarterback Dillon Gabriel is under siege. He’s been sacked 38 times through six games, and last week’s performance (183 yards on 52 attempts) highlighted Cleveland’s inability to push the ball downfield. Even with solid protection early, receivers struggled to separate, and the Browns finished with a meager 4.3 yards per attempt. On the bright side, the defense continues to compete – they held Pittsburgh under 250 passing yards and forced a pair of punts inside their own territory – but the lack of complementary football is glaring.

Miami’s offense, conversely, remains explosive but inconsistent. Tagovailoa threw for 205 yards with a touchdown and three interceptions in last week’s loss, as the Dolphins once again struggled to protect him and convert red-zone opportunities. Still, Achane’s 128 rushing yards and two touchdowns offered a bright spot, as did Jaylen Waddle’s 95-yard performance. The concern remains on defense, where Miami has now allowed 25+ points in five straight games, including multiple long drives to close out contests.

The matchup here is one of complete contrast: Miami’s elite speed and spacing versus Cleveland’s top-heavy, bend-don’t-break defense. The Browns’ defense ranks 11th in yards allowed per game, but their offense ranks dead last in scoring (13.7 points per game). That imbalance makes it hard to back them against even a flawed Dolphins team. Expect Mike McDaniel to lean on motion-heavy concepts and short passing to neutralize Cleveland’s front, while Gabriel and the Browns will once again struggle to sustain drives.

Miami Dolphins vs. Cleveland Browns Predictions

Dolphins -2.5 (-120)
Miami’s offensive ceiling is simply higher. Even if Tua isn’t perfect, Achane and Waddle can create enough explosives to separate from a stagnant Browns offense.

Under 40.5 (-105)
Cleveland can’t finish drives, and Miami may not need to push tempo if they build a lead. Both defenses are capable of generating red-zone stops to keep this under the number.

Dolphins ML (-148)
Tagovailoa’s experience and McDaniel’s scheming outweigh Cleveland’s QB instability. Expect a lower-scoring, methodical Miami win — something like 23–16.

Bet: Dolphins ML (-148), Dolphins -2.5 (-120), Under 40.5 (-105)

New Orleans Saints vs. Chicago Bears Odds

The Chicago Bears return to Soldier Field riding a three-game streak and some real week-to-week improvement. Caleb Williams was efficient again in the late win at Washington (17/29, 252 yards, 1 TD), while D’Andre Swift gave them needed balance and juice after popping a 55-yard catch-and-run and leading the team in scrimmage yards. With T.J. Edwards cleaning up at the second level and Kyler Gordon back in the mix, the defense has settled down after a bumpy September.

The New Orleans Saints dropped to 1-5 after a 25-19 home loss to New England. Spencer Rattler posted his best pro outing (20/26, 227 yards), but the Saints were still stuck in the mud, and the run game never found traction (Alvin Kamara: 10 rushes, 31 yards). That profile has been the story: flashes of efficient, quick-game passing, not much explosive juice, and a defense that asks a lot of takeaways to get off the field.

The trenches lean in favor of Chicago. The Bears’ offensive line has protected better the past two weeks, and the scheme has emphasized rhythm throws that keep Williams ahead of the sticks. Against a Saints front that has struggled to consistently win on early downs, Chicago should be able to string together long drives and set up red-zone cracks for Swift and Cole Kmet.

New Orleans needs chunk plays to hang. Rattler, Chris Olave, and Rashid Shaheed can stress vertically, and Kamara’s receiving gives them some third-down answers, but if the Saints are forced into sustained, mistake-free drives again, Chicago’s improved tackling and situational defense should tilt time of possession toward the home side.

New Orleans Saints vs. Chicago Bears Predictions

Spread – Bears -6.5 (-110).
Chicago’s offense is trending up with cleaner protection and better sequencing, and the Bears’ defense has stabilized with key starters back. Over four quarters, their balance should stretch this to a one-score-plus margin.

Total – Over 47.5 (-105).
Chicago’s recent games have produced sustained drives and late scoring, and the Saints’ speed at WR creates a few explosive chances even in a loss. Both teams have enough pass-game efficiency to push this into the low-50s.

Moneyline – Bears ML (-245).
As the healthier, more complete team at home, Chicago is the safer anchor for parlays and bankroll management.

Bet: Bears ML (-245), Bears -6.5 (-110), Over 47.5 (-105)

New York Giants vs. Denver Broncos Odds

The New York Giants head to altitude after a statement win over the Eagles, where Brian Daboll’s group finally married a clean(er) passing day with a downhill rushing attack. Jaxson Dart pushed the ball efficiently to Wan’Dale Robinson and Lil’Jordan Humphrey, while rookie Cam Skattebo bullied his way to 98 yards and three scores. New York still allowed negative plays, though – Dart took two sacks and threw a pick – and that volatility tends to show up on the road, especially against a defense that tackles well in space.

The Denver Broncos keep stacking defensive performances. Vance Joseph’s unit strangled the Jets last week, holding Justin Fields to 45 passing yards, rally–tackling Garrett Wilson on first contact, and living in second–and–long. The Broncos are communicating much better on the back end, which lets them fit the run with extra bodies and squeeze explosive plays – precisely the thing New York leaned on to bury Philadelphia.

The offensive story is different. Bo Nix has been careful with the ball, but the Broncos still bog down, ranking near the bottom in explosive pass rate and finishing drives. Against the Jets, Denver managed just 13 points despite favorable field position and multiple short–yardage chances. Sean Payton has leaned on a committee around J.K. Dobbins, yet the interior run game remains inconsistent.

Matchup–wise, Denver’s edge is up front on defense and in the situational battle. The Giants’ line has improved, but it’s still a unit you can win against with simulated pressure and late safety rotation—two Joseph staples. Add in thin mountain air, a potential letdown spot for New York after a divisional upset, and Denver’s ability to control tempo with defense and special teams, and the game script tilts toward a Broncos cover in a lower–scoring environment.

New York Giants vs. Denver Broncos Predictions

Spread – Broncos -7 (-110)
Denver’s defense has stabilized and is set up to force Dart into third–and–long. With the Broncos’ tackling advantage and altitude tax on an up–tempo Giants offense, the home side has the better path to multiple short fields and a one–score–plus margin.

Total – Under 39.5 (-105)
Both offenses are methodical, both defenses are tackling, and Denver games routinely grind. Even with some explosive threats on New York’s side, the Broncos’ quarters/robber looks limit YAC and keep the clock moving.

Moneyline – Broncos -360
If you’re building parlays, Denver’s defense and special teams edge make the favorite the safer anchor.

Bet: Broncos ML (-360), Broncos -7 (-110), Under 39.5 (-105)

Indianapolis Colts vs. Los Angeles Chargers Odds

The Indianapolis Colts head to SoFi with a balanced attack that’s been humming behind Jonathan Taylor and a play-action passing game that limits mistakes. In last week’s 31–27 win over Arizona, Indianapolis rushed for 150 yards (Taylor: 21 carries, 123 yards, TD) and Daniel Jones efficiently distributed the ball (22/30, 212 yards, 2 TDs), letting Shane Steichen stay in favorable down-and-distance all afternoon.

The Los Angeles Chargers survived Miami, 29–27, but it was a white-knuckle finish. Justin Herbert made big throws (Ladd McConkey: 7/100/1), yet he also put the ball in harm’s way (2 INTs) and L.A. again leaned on rookie back Kimani Vidal (18 for 124) to steady the offense. Brandon Staley’s defense yielded 137 rushing yards to the Dolphins and struggled to finish drives, allowing 27 points despite keeping Tua Tagovailoa to 205 passing yards.

Matchup-wise, Indy’s physical run game is the lever. The Colts are comfortable living in 12 personnel and hammering inside zone/duo; that’s a problem for a Chargers front that has bled chunk gains on the ground and ranks near the bottom in explosive-run rate allowed. If L.A. commits extra bodies, Steichen’s shot plays to Josh Downs and Alec Pierce come alive against a secondary that can be had outside the numbers.

Conversely, Herbert still threatens every blade of grass, and Shane Waldron’s motion/play-action package manufactures open intermediates for McConkey and Keenan Allen. But with the Colts’ pass rush able to win on early downs and the Chargers’ protection occasionally leaky, Indy should force enough third-and-longs to keep this within a field goal either way.

Indianapolis Colts vs. Los Angeles Chargers Predictions

Spread pick – Colts +1.5 (-108)
Indy’s ability to control script with Taylor, plus the Chargers’ run-defense issues (137 allowed to Miami last week), tilt the matchup toward a one-score grinder. I’ll grab the points with the more consistent trench play.

Total pick – Over 48.5 (-110)
Both offenses create explosives – Herbert to McConkey/Allen, Jones off play-action – and both defenses are vulnerable in the run game. With red-zone weapons on each side, 50+ is a reasonable range.

Moneyline pick – Colts +105
Steichen’s plan travels, the Colts are cleaner in the turnover column right now, and their run game is the best unit on the field. Live dog.

Bet: Colts ML (+105), Colts +1.5 (-108), Over 48.5 (-110)

Green Bay Packers vs. Arizona Cardinals Odds

The Green Bay Packers head to the desert off a 27-18 win over Cincinnati that finally looked like a clean step forward for Matt LaFleur’s offense. Jordan Love managed the game well and, more importantly, the run game showed real teeth with Josh Jacobs pounding for 93 yards and two scores while the line generated steady push. That balance matters against a Cardinals front that has been most vulnerable when opponents stay ahead of the sticks.

The Arizona Cardinals fell 31-27 at Indianapolis in a game where the defense again leaked explosives. The Colts ripped off 150 rushing yards at 5.6 per carry and hit several chunk gains through the air. If that same light box problem shows up, Green Bay’s downhill run game can control tempo and set up play-action shots to Romeo Doubs, Dontayvion Wicks, and Matthew Golden.

The quarterback and receiver health watch looms over Arizona. Kyler Murray is trending doubtful with a foot injury, and Marvin Harrison Jr. left last week with a concussion. If both sit, Jacoby Brissett likely starts and the passing tree condenses to Trey McBride, Zay Jones, and Michael Wilson. Brissett is capable of moving the chains, but sustained red-zone efficiency has been inconsistent without Murray’s off-script creation.

Green Bay’s defense is not flawless, yet it has rushed the passer well in key spots and limits explosives better than Arizona’s unit. With the Packers’ offense rounding into form and the Cardinals’ defense struggling to finish drives, the matchup tilts toward a comfortable road result for Green Bay, with Arizona doing just enough to help the total.

Green Bay Packers vs. Arizona Cardinals Predictions

Spread – Packers -6.5 (-115)
The injuries on Arizona’s side and the Packers’ improving run game create a clear path to a one-score cover. Green Bay has the trench edge and the more reliable red-zone profile.

Total – Over 44.5 (-108)
Green Bay’s balance should produce mid-20s to high-20s by itself, and Arizona has enough underneath answers with McBride to push this into the mid-40s.

Moneyline – Packers ML (-325)
With Murray unlikely and the Cardinals’ defense reeling, Green Bay is the safer side to anchor parlays.

Bet: Packers -6.5 (-115), Over 44.5 (-108), Packers ML (-325)

Washington Commanders vs. Dallas Cowboys Odds

The Washington Commanders head to Arlington fresh off a heartbreaking 25-24 loss at home to Chicago. Jayden Daniels completed 76.9% of his throws, the ground game chipped in 124 yards, and the offense again spread the ball to a deep receiver room led by Chris Moore and Zach Ertz. The bigger storyline was balance: Washington posted 211 passing yards with only three sacks taken and finished 7.0 yards per pass attempt.

The Dallas Cowboys, meanwhile, let one slip in Charlotte. Dak Prescott threw for 261 and three scores, but the run game was a non-factor and the defense was gashed for 216 rushing yards by Rico Dowdle. That is notable against a Commanders team that just put 31 designed runs on tape and has quietly been efficient on early downs. If the Cowboys cannot get off blocks on the edges, Washington can keep Dak on the sideline and shorten this game.

Where Dallas still holds a clear edge is the passing game. George Pickens and a deep tight-end group face a Commanders secondary that sits middle of the pack in explosives allowed and will be on the road on short rest. Washington must speed up its protection rules after allowing three sacks in Chicago and avoid negative plays..

Tempo and red-zone efficiency both point toward points. Dallas ranks top tier in pass rate over expectation in neutral situations, while Washington is consistently aggressive on fourth down. With both teams’ best matchups through the air and both kickers in range, sustained drives should turn into touchdowns more than field goals.

Washington Commanders vs. Dallas Cowboys Predictions

Spread – Commanders +2.5 (-110)
Washington’s balance on early downs matches up with a Dallas front that just yielded 5.7 yards per carry. If the Commanders can keep Daniels clean on first down, they can stay ahead of the sticks and turn this into a one-score, fourth-quarter game. I’ll take the points.

Total – Over 54.5 (-115)
Prescott is dealing, Washington’s route tree creates YAC, and both offenses are aggressive in the red zone. Dallas’ run defense wobble plus Washington’s secondary vulnerability sets up for trading touchdowns, not threes.

Moneyline – Commanders +142
Live underdog. Washington’s offensive multiplicity and fourth-down aggression give them enough paths to win outright if they steal an extra possession or two.

Bet: Commanders +2.5 (-110), Over 54.5 (-115), Commanders ML (+142)

Atlanta Falcons vs. San Francisco 49ers Odds

The Atlanta Falcons arrive on Sunday night with some momentum after handling Buffalo 24–14 last Monday night. The offense finally leaned into his best players, with Bijan Robinson erupting for 170 rushing yards on 19 carries and Drake London posting a 10–158–1 line as the passing game found rhythm. Atlanta’s defense did its part, holding Josh Allen to 180 yards with two interceptions and limiting explosive plays on the perimeter.

San Francisco is trying to steady itself with Mac Jones likely starting again for the injured Brock Purdy. The box score was encouraging in volume last week, as Jones threw for 347 yards, but protection was a problem with six sacks, and the ground game never quite got going with Christian McCaffrey at 17–54. If George Kittle returns, even in a limited role, that is a stabilizer on third downs and in the red zone for Kyle Shanahan’s play-action menu.

Tactically, this swings on trench play. Atlanta just bludgeoned Buffalo for 210 team rushing yards and has quietly become more physical up front. The 49ers’ run fits wobbled in Tampa, yet they still have the edge rusher depth to stress Atlanta’s play-action shots and keep Michael Penix in obvious passing downs if the Falcons fall behind schedule. On the other side, San Francisco’s passing script should prioritize quick game and YAC throws to mitigate pressure while testing Atlanta’s linebackers in coverage with CMC.

Both teams are efficient inside the 20, but each prefers long, methodical drives. With Atlanta’s defense trending up and the 49ers likely emphasizing ball control with Jones, possessions may be limited. That sets up a close, lower-variance contest that favors the slightly deeper roster at home, especially if Kittle gives San Francisco another reliable chain-mover.

Atlanta Falcons vs. San Francisco 49ers Predictions

Spread – 49ers -2.5 (-108)
San Francisco’s pass-pro plan should look sharper in Week 7, and the defense matches up well with Atlanta’s play-action, outside-zone attack. With potential help from Kittle, the 49ers have enough answers to win by at least a field goal.

Total – Under 47.5 (-115)
Both offenses prefer slow, sustained possessions, and Atlanta’s recent defensive form plus San Francisco’s quick-game approach point to fewer explosives. A script in the low-to-mid 40s fits.

Moneyline – 49ers -1365

Home field, a small quarterback edge in this matchup’s structure, and potential reinforcements at tight end tilt the straight-up outcome toward San Francisco.

Bet: 49ers ML (-135), 49ers -2.5 (-108), Under 47.5 (-115)

Tampa Bay Buccaneers vs. Detroit Lions Odds 

The Detroit Lions return home in prime time with an offense humming on early downs. The offense remains among the league’s most efficient in scripted drives, and Jared Goff continues to spread the ball evenly to Amon-Ra St. Brown, Sam LaPorta, and Jameson Williams. The Lions’ offensive line, still one of the NFL’s best in pass-block win rate, faces another test against a Tampa Bay front that just sacked Mac Jones six times and forced two fumbles in last week’s 30–19 win over San Francisco.

For the Tampa Bay Buccaneers, Baker Mayfield has quietly played his best football in years. He threw for 256 yards and two touchdowns against the 49ers, spreading the ball between Cade Otton, Rachaad White, and Sterling Shepard. Tampa’s defense is opportunistic but inconsistent – the Bucs gave up 347 passing yards in that win – and now face a Lions offense that leads the NFC in first downs per game. Injuries are also piling up in the receiving corps, with all of Emeka Egbuka, Mike Evans, and Chris Godwin likely to miss this one.

The key matchup lies in the trenches. Detroit’s balance allows them to shift seamlessly between power runs and play-action shots, while Tampa Bay’s front seven can be gashed if Vita Vea doesn’t control the interior. Expect the Lions to test the Bucs with motion and quick throws to mitigate pressure and get Gibbs into space. Conversely, Mayfield will need to rely on rhythm throws to avoid the kind of long third downs that Detroit’s defense feasts on.

Both teams have top-10 red-zone efficiency, but Detroit’s play design gives it a higher ceiling. Tampa Bay may hang around early with its vertical passing attack, yet the Lions’ offensive depth and pace at home should prove too much by the fourth quarter.

Tampa Bay Buccaneers vs. Detroit Lions Predictions

Spread – Lions -6.5 (-110)
Detroit’s offense has been sharper at home, and Goff’s efficiency behind a clean pocket is the difference. The Lions should separate late and win by a touchdown or more.

Total – Over 52.5 (-118)
Both teams have shown the ability to finish drives. With Detroit’s creativity and Tampa Bay’s quick-strike potential, this projects as a high-scoring primetime game in the mid-50s.

Moneyline – Lions -245
Detroit has the deeper, more balanced roster, and the return to Ford Field sets up well for a statement win in front of a national audience.

Bet: Lions ML (-245), Lions -6.5 (-110), Over 52.5 (-118)

Houston Texans vs. Seattle Seahawks Odds 

The Houston Texans return from a bye with a clean bill of health and the confidence of a 44–10 route two weeks ago. C.J. Stroud was surgical in that win, and Houston mixed in enough ground efficiency to stay ahead of the chains. Slowing things down and protecting the ball has been a core feature of this offense all season.

The Seattle Seahawks just handled Jacksonville 20–12 on the road. Sam Darnold pushed the ball downfield to create explosives, while the defense stole the show by squeezing the pocket and piling up negative plays. That front has been consistently disruptive, and it pairs well with a secondary that keeps throws in front and rallies to tackle.

This matchup tilts toward a slower script. Seattle’s offense under Darnold has leaned on play-action, boot, and a steady run game to stay on schedule rather than push tempo. After a bye, Houston’s staff typically opens with a measured first quarter and emphasizes ball security, which shortens games and reduces total possessions.

Home-field noise should matter on third downs. If Seattle’s pass rush wins enough early passing situations, Stroud will be forced into check-downs and long fields. Houston can certainly trade punches, but Seattle’s combination of pass rush, tackling, and red-zone defense gives the Seahawks a small but real edge.

Houston Texans vs. Seattle Seahawks Predictions

Spread – Seahawks -3 (-120)
Lumen Field noise plus Seattle’s pass rush is a tough ask for any offense, even a well-coached, efficient one. With Seattle more likely to control field position, I’ll lay the three.

Total – Under 41.5 (-112)
Both teams are comfortable living in second-and-medium, and each defense tackles well. Fewer explosives and a modest pace point to a game played in the high 30s to low 40s.

Moneyline – Seahawks -170
If you want a safer anchor for parlays, Seattle’s moneyline is preferable to the spread in what projects as a one-score game.

Bet: Seahawks ML (-170), Seahawks -3 (-120), Under 41.5 (-112)

NFL Week 7 Best Bets

The following are my three favorite bets for Week 7:

• San Francisco 49ers -2.5 vs. Atlanta Falcons (-108)
  
• Detroit Lions -6.5 vs. Tampa Bay Buccaneers (-110)
  
• Seattle Seahawks -3 vs. Houston Texans (-120)
  

San Francisco’s coming off back-to-back road games and finally returns home for Sunday Night Football. With George Kittle likely back in the lineup and Christian McCaffrey continuing to handle a massive workload, the Niners’ balance should keep Atlanta’s front off-balance. Michael Penix Jr. has played poised for the Falcons, but facing a tough defense and a collapsing pocket in Santa Clara is a tougher task. Expect San Francisco’s run defense to hold up and the offense to grind out drives behind McCaffrey’s efficiency.

Detroit hosts Tampa Bay in Monday Night Football and should thrive at Ford Field, where Jared Goff is still one of the league’s most efficient passers. The creative offense continues to generate high-percentage looks for Amon-Ra St. Brown and Sam LaPorta, while Jahmyr Gibbs’ burst adds another layer. Baker Mayfield’s group has fought hard, but the Bucs’ defense has been gashed for chunk plays lately – and Detroit’s pass protection is elite. The Lions’ edge on both lines should be the difference.

Seattle welcomes Houston after the Texans’ bye week, and this shapes up as a low-possession, field-position battle. C.J. Stroud has been impressive, but Lumen Field noise and a rested Seahawks defense could tilt this one. Sam Darnold’s chemistry with Jaxon Smith-Njigba continues to build, and Seattle’s balance at home gives them the advantage in a grind-it-out spot.

If you roll these three into an NFL parlay at approximate prices of -108, -110, and -120, the combined odds land around +595. A $100 wager would return about $695 total ($595 profit). For more parlay bets, check out our best NFL parlays for every week – and for college fans, we’ve got some College Football parlay picks as well.