The 2025 college football season is flying by, as we are already to week eight. The CFB Championship picture is starting to clear up, but a big week awaits for even more answers to our burning questions. The week 8 college football odds are up at most online sportsbooks, too, which means you can bet on most of the marquee matches.

Week 7 in college football was awesome, so what can week eight do for an encore? Luckily, the schedule is jam-packed with some intense matchups, including a showdown between #2 Georgia and #14 Ole Miss, a clash between #7 Tennessee and #11 Alabama, and more.

It’s a loaded week, and that’s just scratching the surface as these teams all continue their path to the College Football Playoffs. Want the latest prices and/or aren’t quite sure how to bet on the week 8 college football lines? I’ve got you covered with this full betting guide, stocked with picks and predictions for the best Top 25 games of the week.

College Football Week 8 Schedule 

College Football Week 8 Odds 

The College Football odds are constantly changing, to be sure to monitor the lines throughout the week. 

Several week 8 college football point spreads are bound to be outlandish. Oregon is one of them, as the top-seeded team in the nation takes on the inferior Rutgers Scarlet Knights. Notre Dame opens as almost a two-touchdown favorite (-12.5) in their matchup with USC as well, while Clemson (-11.5) and Alabama (-12.5) are big favorites this week, too.

Georgia is only a 9.5-point home favorite against Ole Miss, in what is one of the more surprising week 8 college football lines at the top sports betting sites. More week eight college football betting odds will drop before long, but we have plenty to work with and can project most of the games without pricing.

Once you’re ready to place some bets, you can turn to my week 8 college football picks or use the top sports betting handicappers the internet has to offer.

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College Football Week 8 Predictions

Let’s take a look at the featured College Football Week 8 games and make our NCAAF Picks for each game. 

UNLV Rebels vs. Boise State Broncos Odds 

The UNLV Rebels and the Boise State Broncos meet for the 15th time ever in week eight, as UNLV will try to cut down the gap in a series they trail 11-3. 

Boise State has dominated this series, with UNLV’s last win coming way back in 1976. UNLV did get them a run for their money in the Mountain West Conference a year ago, though, and kept it relatively close in the MW title game (21-7).

While UNLV couldn’t claim the conference championship, they nearly bested Boise State last October, when they fell 29-24 in a nail-biter.

UNLV Rebels vs. Boise State Broncos Predictions

The Rebels may not be quite on par with their conference rivals, but their only loss in the Mountain West came to Boise State last year, and they otherwise enjoyed a terrific 11-3 showing in 2024.

UNLV poses a bigger threat than many suspect, as they had a dominant rushing attack (9th in rushing) last year, and also put up 32.5 points per game. The Rebels also boasted the nation’s 20th best sack rate and 23rd best run defense, giving them the balance they need to hope for a big upset.

Boise State will be the rightful favorite at home, but the Rebels are going to be a very compelling ATS pick. They have faced UNLV in two straight Mountain West title games, and the last two games were painfully close. I still think the Broncos get the win, but UNLV against the spread will be a bet I target if the line is right.

Bet: Boise State Broncos 

Tennessee Volunteers vs. Alabama Crimson Tide Odds 

We get a fun rivalry game from inside the SEC in week eight, as the 7th ranked Tennessee Volunteers head down south to battle the 11th ranked Alabama Crimson Tide.

Alabama has understandably dominated the season series (59-40-7), but the Vols have the leg up in recent history. Tennessee is 2-1 over the last three meetings, with the Volunteers winning last year’s showdown in a 24-17 thriller.

Tennessee Volunteers vs. Alabama Crimson Tide Predictions

Tennessee is the better team on paper so far, and that has a lot to do with coaching and talent changes over the past couple of years. Alabama lost dual threat quarterback Jalen Milroe to the NFL Draft, and their offense isn’t a lock to be nearly as dangerous.

We know the Crimson Tide always have top shelf defenses, though, as they were 9th in points allowed in 2024 and were especially nasty against the pass. The Vols might again have an answer for that, though, as they own one of the nation’s most dominant ground games.

Ultimately, I do think Alabama takes care of business at home. However, Tennessee has played them extremely well lately, and their rushing offense should allow them to at least stay in this one.

Bet: Tennessee Volunteers +12.5 (-110)

SMU Mustangs vs. Clemson Tigers Odds 

The SMU Mustangs and Clemson Tigers give us one of the more intense week 8 college football matchups, as both teams are ranked inside the top-16 as of this writing.

SMU has only faced Clemson once, and it was for all the marbles in last year’s ACC Championship game. Clemson won, but it didn’t come easy, with the Mustangs putting up 31 points in a narrow three-point loss.

SMU Mustangs vs. Clemson Tigers Predictions

Clemson had a dog fight on their hands the last time these two sides met, so it’s a little shocking that they are almost 12-point favorites to win the rematch.

The Mustangs boast an elite offense (13th in scoring last year) that is very balanced and helped them to an 11-3 record (8-0 in the ACC) a year ago. 

Dual threat quarterback Kevin Jennings was a huge reason for their success in his first full season under center, and he was particularly impressive in that ACC title game. If he offers up that type of effort again, I love SMU to keep it tight and beat this spread.

Bet: SMU Mustangs +11.5 (-110)

Oklahoma Sooners vs. South Carolina Gamecocks Odds 

This battle between the Oklahoma Sooners and South Carolina Gamecocks doesn’t presently have odds, but 15th ranked SC should be favored by a wide margin.

Oklahoma has only faced South Carolina once ever, but it was a convincing 35-9 beatdown in October of last year. A year later, the two sides prepare to face off for a second time.

Oklahoma Sooners vs. South Carolina Gamecocks Predictions

The Sooners are not the juggernauts they once were. They finished just 2-6 inside the SEC last year (6-7 overall) and don’t have the coaching or talent they did just a few years ago.

Oklahoma was still pretty good defensively last year, but their offense has a long way to go and will be the chief reason they won’t be expected to put up much of a fight in this one.

South Carolina benefits from being at home in week 8, while they have an even better defense than the Sooners, as well as a far more capable offense. Quarterback LaNorris Sellers was a dual threat dynamo in his first full season of work in 2024, and he should be expected to dominate Oklahoma for the second game in a row.

Bet: South Carolina Gamecocks (NA)

Ole Miss Rebels vs. Georgia Bulldogs Odds 

The Ole Miss Rebels take on the Georgia Bulldogs in week eight, setting up a premium SEC battle. This is a series in which Georgia has dominated (33-13-1) over time, but it was actually Ole Miss that got the last laugh with a 28-10 win in 2024.

Ole Miss has now won two of the last three meetings, although the Bulldogs won easily (52-17) in 2023.

Ole Miss Rebels vs. Georgia Bulldogs Predictions

The big issue here is the fact that Ole Miss might be taking a step back in 2025. They lost star quarterback Jaxson Dart and several other key offensive contributors to the NFL Draft.

The coaching and offensive approach is still there, but that’s why Ole Miss is a hefty road dog, even after coasting to an 18-point win the year prior.

Georgia has also endured plenty of turnover the last two years, but they’re in a better spot and are a top-5 team in the nation. Given their superior coaching and defensive bite, it’s hard not to like them in this one at home.

Bet: George Bulldogs -9.5 (-110)

Penn State Nittany Lions vs. Iowa Hawkeyes Odds 

The Penn State Nittany Lions hit the road in week eight to take on the rival Iowa Hawkeyes. This tense clash gives CFB fans a match they’ve seen 32 times already, but is still one that never gets old.

The series has been tight throughout history, with Penn State holding a mild 18-14 advantage. The Nittany Lions won the most recent meeting rather easily (31-0) in 2023, and have secured the victory in seven of the last nine showdowns.

Penn State vs. Iowa Predictions

The Nittany Lions lost some big weapons this off-season, but still have stud passer Drew Allar on hand to guide a dynamic offense. Allar smoked this Hawkeyes defense for four passing touchdowns when he last faced them in 2023, and it’s unlikely that we see a different result in 2025.

Iowa was actually decent last year, going 6-3 inside the increasingly competitive Big 10 and going 8-5 overall. However, the Hawkeyes continue to be a defense-first program that still probably can’t contain Penn State, nor can they keep up with them.

Bet: Penn State Nittany Lions (NA)

Ohio State Buckeyes vs. Wisconsin Badgers Odds 

The Ohio State Buckeyes continue their tradition of beating up on the Wisconsin Badgers in week eight. This is certainly a huge Big 10 clash, but these teams are not on the same level and really never have been, with the Buckeyes owning a 63-18-5 advantage.

Ohio State has won each of the last 10 meetings, with the most recent being an easy 24-10 win in Madison. Each of the last four games have been decided by two scores or more.

Ohio State Buckeyes vs. Wisconsin Badgers Predictions

It will not come as a shock to anyone that Ohio State is a big favorite here despite playing this game on the road. They’ve dominated Wisconsin for years, and they come in as a top-5 team in the country, meanwhile the Badgers aren’t even ranked.

The Buckeyes are also the defending champions with another title on the brain. They could regress slightly after losing a ton of offensive talent to the NFL Draft, but they have the coaching and recruiting to keep rolling all the way through this Big 10 showdown.

Bet: Ohio State Buckeyes (NA)

Oregon Ducks vs. Rutgers Scarlet Knights Odds 

The top-seeded Oregon Ducks prepare to battle the Rutgers Scarlet Knights this week. Oregon and Rutgers have never faced each other throughout their respective school history.

With the Ducks joining the Big 10 last August, they’ll finally face Rutgers for the first time ever in week 8.

Oregon Ducks vs. Rutgers Scarlet Knights Predictions

The Ducks are the #1 team in the nation, despite losing some key offensive stars like quarterback Dillon Gabriel to the NFL Draft. Oregon is still one of the nastier offensive teams in the country, however, and are going to be far too much for Rutgers to deal with.

To their credit, the Scarlet Knights got four wins inside the Big 10 last year and finished with a winning record (7-6). They also boast a balanced and reasonably explosive offense, led by quarterback Athan Kaliakmanis.

Their offensive aptitude might convince me to hammer the Over in this one, but all paths should lead to a (convincing) Oregon victory.

Bet: Oregon Ducks -15.5 (-110)

Texas Longhorns vs. Kentucky Wildcats Odds 

The Texas Longhorns prepare to wage war with the Kentucky Wildcats, in a game that should boast a large week 8 college football point spread.

Texas and Kentucky have only met two times before this season, with the Longhorns prevailing as the winner in both meetings. Texas won the most recent meeting (31-14) last year, while the only other matchup came all the way back in 1951.

Texas Longhorns vs. Kentucky Wildcats Predictions

Texas is the #3 ranked team in the country, so they’ll be fully expected to win. Star quarterback Arch Manning is still trying to put the finishing touches on a Heisman campaign, while his Longhorns have hopes of contending for a title.

Getting tripped up by Kentucky is not on their bingo card. The Wildcats were the second worst team in the SEC last year (1-7), as they pose very little threat offensively, and don’t have a defense good enough to slow down Texas and their many weapons.

This one has the makings of a rout. The Longhorns are the easy ML pick and I fully expect them to cover.

Bet: Texas Longhorns (NA)

USC Trojans vs. Notre Dame Fighting Irish Odds 

The USC Trojans and Notre Dame Fighting Irish face off in an underrated week 8 clash, in what will be the 93rd clash between these two sides.

Notre Dame holds the all-time edge (50-37-5), and has won shootouts in each of the last two years. The 2024 battle (49-35) was must-see TV, while Notre Dame has had the upper hand for a while now, winning six of the last seven affairs.

USC Trojans vs. Notre Dame Fighting Irish Predictions

The Trojans remain a well-coached team with offensive aptitude. Last year’s shootout with this very Notre Dame squad was a reminder of that.

 Jayden Maiva is ready to be the team’s full-time leader under center, and his 5-touchdown effort against the Fighting Irish serves as an example of what he’s capable of.

Of course, Notre Dame has bigger fish to fry. They almost won the whole thing last season and will have their sights set on completing the task. Getting tripped up at home against a lesser USC team isn’t something they’ll take kindly to.

Due to that – and Notre Dame’s superior talent – I love the Fighting Irish as a straight up bet. However, USC has enough offense to keep this interesting, making them a solid ATS play and the Over perhaps the most alluring wager of all.

Bet: Notre Dame Fighting Irish (NA)

Best College Football Week 8 Bets

There are a plenty of worthwhile week 8 college football picks to wager on, but the following are my best bets for the week:

• Georgia Bulldogs -9.5 (-110)
• Tennessee Volunteers +12.5 (-110)
• SMU Mustangs +11.5 (-110)

I am sure more week 8 college football lines will present themselves as appealing wagers to attack, but these are my three favorites right now.

There are a lot of college football teams still looking to state their case for a run to the College Football Playoff, while others simply want to play the spoiler role. That said, Georgia feels like the easiest team to click this week, as I definitely like their chances to beat Ole Miss by at least 10 points.

Tennessee and SMU have made believers out of me. It’s also partially that I don’t exactly trust the current renditions of Clemson and Alabama, but the Vols and Mustangs both looked great last year and should be able to hang tight in their respective matchups.

There is room for some solid value with week 8 college football odds, and hopefully the picks above help you cruise to some cash.