Chicago Cubs vs San Francisco Giants Picks and Predictions May 5th 2025

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Momentum Meets at Wrigley: Cubs Host Surging Giants

Two of the hottest squads in the National League square off Monday night as the Chicago Cubs welcome the San Francisco Giants to Wrigley Field. Both teams are fresh off impressive weekend series wins and are looking to keep the momentum going as May rolls in.

The Cubs have been nothing short of dominant lately, winning three of their last four, including a convincing series win over the Milwaukee Brewers. In that series, Chicago outscored Milwaukee 16-2 in the first two games before a 4-0 hiccup on Sunday.

That loss wasn’t just about the scoreboard — it came with a health scare. Star pitcher Shota Imanaga left the game with a left hamstring strain, and the team is still waiting on MRI results to assess how serious it is.

Outfielder Kyle Tucker summed up the mood in the clubhouse:

“Obviously, you don’t want that to happen to anyone. He’s been great for us.”

Despite the injury, the Cubs remain atop the National League in key offensive metrics, leading in batting average, slugging, and runs scored. With a strong bullpen and deep lineup, they’re a force at home.

Stay updated on Chicago’s performance trends via the MLB Team Page.

Matthew Boyd Takes the Ball for Chicago

The Cubs will send out veteran Matthew Boyd (2-2, 2.70 ERA), who has been a reliable part of the rotation. The 34-year-old southpaw is coming off a no-decision in Pittsburgh where he gave up two earned runs over five innings. It wasn’t flashy, but it was steady.

Boyd signed a two-year, $29 million contract this past offseason and has quietly put together a solid campaign. Monday marks his first-ever start against the Giants in his 10-year career — a fun subplot as he takes the mound at historic Wrigley.

You can find detailed breakdowns and predictions on upcoming matchups at the MLB Picks Page.

Giants Lean on Adames and Offense After Big Weekend

The San Francisco Giants roll into town after taking three of four from the Colorado Rockies — the kind of series you have to dominate if you want to stay in playoff contention.

Shortstop Willy Adames found his groove in that series, delivering six hits and crushing his first two home homers of the season in Sunday’s 9-3 win. After a slow start, he’s now batting .230 with four home runs and 18 RBIs.

Adames credited his recent surge to preparation:

“I feel like the work we’ve been putting in is paying off. Hopefully, we can build from that.”

Known for his battles against the Cubs during his days in the NL Central, Adames is no stranger to Chicago’s atmosphere and competitive edge. He knows this series will be a real test for the Giants.

San Francisco’s lineup has started to click, and with solid bullpen support, they’ve proven they can go toe-to-toe with top-tier teams.

For expert insight and game previews, check out the MLB Expert Betting Guide.

Roupp Gets the Nod in First Career Start vs Cubs

Giants righty Landen Roupp (2-2, 5.10 ERA) gets the call Monday night. Roupp is still carving out his place in the big leagues, and Monday will be his first time facing the Cubs. In his last outing, he gave up four earned runs on seven hits in just over four innings against the Padres.

At 26 years old and still adjusting to MLB hitters, Roupp has shown flashes but has struggled with command and limiting big innings. His ability to get ahead in counts and manage Chicago’s power bats will be critical if the Giants hope to steal Game 1 on the road.

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What to Watch in This Matchup

This matchup brings plenty of intrigue. The Cubs are red-hot offensively and boast one of the best lineups in the league. Meanwhile, the Giants are gaining steam with players like Adames heating up at just the right time.

Chicago’s ability to bounce back from Imanaga’s injury and whether Boyd can keep the Giants in check will be key storylines. San Francisco will rely on timely hitting and hope Roupp can give them at least five competitive innings.

Expect a tense, well-matched showdown at Wrigley — one with playoff vibes even in early May.

A baseball pitcher in a red Guardians jersey winds up to throw a pitch, showcasing determination in a dynamic stadium setting.

FAQs

Who are the starting pitchers for Monday’s game?
Matthew Boyd (Cubs) faces Landen Roupp (Giants) in the series opener.

What’s the Cubs’ recent record?
The Cubs have won three of their last four and two of three vs. the Brewers.

Is Shota Imanaga injured?
Yes, he left Sunday’s game with a hamstring strain and will undergo further evaluation.

How is Willy Adames performing for the Giants?
Adames hit his first two home homers Sunday and now has four total this season.

Has Matthew Boyd faced the Giants before?
No, this will be Boyd’s first career start against San Francisco.

How have the Giants been playing recently?
They’ve won three of four against the Rockies and are looking to keep it rolling.

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