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NFL Week 2 of the 2026 regular season has sixteen games, from Thursday, September 17, to Monday, September 21, 2026.
Five of the sixteen games are between division rivals. Thursday night is Detroit Lions at Buffalo Bills on Prime Video; Sunday night is Indianapolis Colts at Kansas City Chiefs on NBC; Monday night is New York Giants at Los Angeles Rams on ESPN, ABC.
All sixteen games are final.
NFL Week 2 predictions
Each card gives the spread, the total and the moneyline, our call once the full prediction is up, and a link to the page.
The Bills vs Lions recap starts with Josh Allen taking control before Detroit could settle into Thursday night. Buffalo scored touchdowns o…
Final: Buffalo Bills 41, Detroit Lions 31, Thursday 17 September at Highmark Stadium.
Cincinnati won 20-6 in Houston. We had two positions and split them: the Texans to win lost, and the under 45.5 won with 26 points scored.
Cleveland won 23-19 in Tampa. We took the Browns +8.5 and they won the game, so the call landed by 12.5.
Kansas City won 33-30 in overtime. We laid the 6.5 with the Chiefs and the call lost by three and a half.
Dallas won 37-20. We had two positions here and split them: Washington +4 lost by 13, and the over 51 won with 57 points scored.
San Francisco won 35-13. We took Miami +13.5 and the call lost by eight and a half.
Philadelphia won 24-20. We took the over 39.5 and it cashed with 44 points on the board.
Denver won 20-13. We took the Jaguars and the points at +2.5, and the call lost by four and a half.
Green Bay won 20-17 in overtime. We took the Packers at -3.5 and the call lost by half a point.
Carolina won 34-3 in Atlanta. We took the Falcons and the points at +2.5, and that call missed by 28 and a half.
Las Vegas won 26-14. We took the Raiders and the 6.5, and they did not need the points.
New Orleans won 24-17 in Baltimore. We took the Saints and the 8.5, and they won the game outright, so the call landed by 15.5.
Seattle won 31-7 in Arizona. We laid the 4 with the Seahawks and they covered it by 20.
New England won 20-3. We passed on the spread, so there is no result to report on the call itself.
Minnesota won 9-3 in Chicago. We took the Vikings and the points at +4.5, and they won outright, so the call was right for more than it nee…
Los Angeles won 28-6. Our best bet was the Giants +6.5 at -105, and it lost by 15.5 points.
NFL Week 2 results
| Kickoff (ET) | Game | TV | Result |
|---|---|---|---|
| Thu Sep 17, 8:15 pm | Detroit Lions at Buffalo Bills | Prime Video | Lions 31, Bills 41 |
| Sun Sep 20, 1:00 pm | Carolina Panthers at Atlanta Falcons | Fox | Panthers 34, Falcons 3 |
| Sun Sep 20, 1:00 pm | Cincinnati Bengals at Houston Texans | CBS | Bengals 20, Texans 6 |
| Sun Sep 20, 1:00 pm | Cleveland Browns at Tampa Bay Buccaneers | CBS | Browns 23, Buccaneers 19 |
| Sun Sep 20, 1:00 pm | Green Bay Packers at New York Jets | Fox | Packers 20, Jets 17 (OT) |
| Sun Sep 20, 1:00 pm | Minnesota Vikings at Chicago Bears | Fox | Vikings 9, Bears 3 |
| Sun Sep 20, 1:00 pm | New Orleans Saints at Baltimore Ravens | CBS | Saints 24, Ravens 17 |
| Sun Sep 20, 1:00 pm | Philadelphia Eagles at Tennessee Titans | Fox | Eagles 24, Titans 20 |
| Sun Sep 20, 1:00 pm | Pittsburgh Steelers at New England Patriots | CBS | Steelers 3, Patriots 20 |
| Sun Sep 20, 4:05 pm | Jacksonville Jaguars at Denver Broncos | CBS | Jaguars 13, Broncos 20 |
| Sun Sep 20, 4:05 pm | Las Vegas Raiders at Los Angeles Chargers | CBS | Raiders 26, Chargers 14 |
| Sun Sep 20, 4:25 pm | Miami Dolphins at San Francisco 49ers | Fox | Dolphins 13, 49ers 35 |
| Sun Sep 20, 4:25 pm | Seattle Seahawks at Arizona Cardinals | Fox | Seahawks 31, Cardinals 7 |
| Sun Sep 20, 4:25 pm | Washington Commanders at Dallas Cowboys | Fox | Commanders 20, Cowboys 37 |
| Sun Sep 20, 8:20 pm | Indianapolis Colts at Kansas City Chiefs | NBC | Colts 30, Chiefs 33 (OT) |
| Mon Sep 21, 8:15 pm | New York Giants at Los Angeles Rams | ESPN, ABC | Giants 6, Rams 28 |
Schedule, TV and scores from ESPN, read 23 October 2026, 20:02 UTC.