With Week 1 in the books, we now turn our attention towards Week 2 of the 2025-26 NFL season starts. And, this week starts off with an exciting Thursday Night Football matchup as the Green Bay Packers host the Washington Commanders in a battle of two Playoff teams from last season.

From there, the weekend will feature six divisional matchups, DK Metcalf and the Steelers hosting his former team the Seattle Seahawks, and a Super Bowl rematch as the Kansas City Chiefs host the Philadelphia Eagles.

The second week of the season will close with two Monday Night Football games. The MNF opener will see the Houston Texans host the Tampa Bay Buccaneers in a battle of divisional winners from a season ago.

The second MNF matchup is an AFC West clash as the Las Vegas Raiders host the Los Angeles Chargers in what should be an exciting atmosphere.

Without any further delay, let’s take a look at the NFL Week 2 odds and make our early Week 2 picks. It’s never to early to get your NFL bets in especially if you can identify value on the boards.

NFL Week 2 Schedule

NFL Week 2 Odds

As of this writing, the early NFL odds for Week 2 indicate that the Baltimore Ravens are the biggest favorite as they host the Cleveland Browns. Not only are they listed at -625 odds, but the Ravens also have a -12.5 spread at most sports betting sites.

Surprisingly, it’s the Jacksonville Jaguars at Cincinnati Bengals that has the highest Total of the weekend at O/U 49.5 points.

Currently, the Philadelphia Eagles are the smallest NFL Underdogs for Week 2 at +100 moneyline and +1.5-point spread. They face the Chiefs in Kansas City.

The Buffalo Bills are the biggest Road Favorite with a -8.5-point spread as they battle AFC East rival the New York Jets. Conversely, that makes the Jets the biggest Home Underdog of the weekend.

If you need some expert assistance in making sense of these early lines or some last-minute help leading up to the Week 2 games, then check out the industry’s best handicapping membership. And, the best part, you can try it for free!

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NFL Week 2 Predictions

Let’s take a look at the full slate of NFL Week 2 matchups and make our NFL picks for each game.

Washington Commanders vs. Green Bay Packers Odds

These two NFC teams have played against each other 40 times including three postseason matchups. The Green Bay Packers hold the advantage with a 22-17-1 series record.

The last time these NFL teams played against each other was in 2022, and the Washington Commanders won at home by the score of 23-21.

The Packers hold a massive advantage in this series when playing at Lambeau Field. They’re an impressive 13-5-1 SU and have won six games in a row.

Washington Commanders vs. Green Bay Packers Predictions

Both of these teams have aspirations of leading the NFC Conference into SB 60. However, last year, it was the Commanders that actually came one game away from the Super Bowl as they lost in the NFC Championship to the Eagles.

This year, the Commanders look poised to make another run at the Conference Title game. They open up the season at home versus the Giants, while the Packers open up the year with a home game against their rival the Detroit Lions.

Could the Packers really go 0-2 to start the season?

This game really comes down to how the Packers do in Week 1 and how well they can stop the run. Last year, the Commanders were 4^th in the league and the Packers were 7^th in stopping the run.

If Green Bay wins in Week 1 then I expect an emotional let down in this TNF game on a short week. Even if they lose in Week 1, I still like the Commanders in this game.

Bet: Washington Commanders (+105), Commanders +1.5 (-110)

Cleveland Browns vs. Baltimore Ravens Odds

This AFC North matchup seems to be a blowout on paper as the Baltimore Ravens host the rebuilding Cleveland Browns.

Looking at past trends and we see that the Ravens have gone 37-15 versus the Browns all-time and have won seven of the last 11 meetings.

Baltimore has also tallied a 20-6 record at home versus Cleveland, which includes winning four of the last five home meetings. The Ravens trounced the Browns last year at home, by the score of 35-10.

Cleveland Browns vs. Baltimore Ravens Predictions

I see no reason to think that the Ravens won’t duplicate their success from last year. The only question is how angry this Baltimore team will be as they open the season in Buffalo which could be a loss.

Take the Ravens to win this game and cover the large spread. Avoid the O/U for now as we have no idea what Cleveland’s offense is going to look like.

Bet: Baltimore Ravens (-625), Ravens -12.5 (-110)

Jacksonville Jaguars vs. Cincinnati Bengals Odds

The Cincinnati Bengals have the easiest opening slate of the season. In Week 1, they play the Browns, and in Week 2, Cincy hosts the Jacksonville Jaguars.

Surprisingly, the Jaguars hold a slight edge in this series with a 13-12 record. However, the Bengals have gone 7-2 over the last nine meetings and have won three in a row.

The last matchup between these two teams came in 2023, and the Bengals won in OT by the score of 34-31.

Jacksonville Jaguars vs. Cincinnati Bengals Predictions

The oddsmakers believe that this game will have the highest score of the week. That also means there should be some juicy NFL player prop bets for this matchup as well. Especially on the Bengals side.

I would imagine Cincy’s moneyline and spread to increase by Week 2. So, lock in the value now, as the Bengals are a superior team on paper and on the field.

Bet: Cincinnati Bengals (-225), Bengals -5.5 (-110)

New York Giants vs. Dallas Cowboys Odds

The New York Giants open up the season with two consecutive NFC East games. And, both of them are on the road which could put this team in an early 0-2 hole for the division and the season.

The Dallas Cowboys start the year off at Philly in the NFL Season Kickoff game. Hard to imagine that they get a win in that one.

The Cowboys own this rivalry with a 77-42-2 all-time record. They’ve also won 15 of the last 16 meetings between the two rivals, which includes eight in a row.

Last year, Dallas won 27-20 at home over the Giants and have gone 11-1 at home in the last 12 meetings at Dallas.

New York Giants vs. Dallas Cowboys Predictions

The Cowboys appear to be turning the ship around from last year. And, with how they have dominated the Giants over the last decade, I see no reason to think anything changes in Week 2. Take Dallas to win and cover as their offense is the catalyst to this NFC East victory.

Bet: Dallas Cowboys (-195), Cowboys -4.5 (-110)

Chicago Bears vs. Detroit Lions Odds

Each of these teams will play their second straight NFC North matchup to begin the season. The Chicago Bears open on MNF against the Vikings, while the Detroit Lions play at Green Bay.

This game marks the 191^st meeting between the two franchises. Chicago holds a large lead in the series with a 105-80-5 record.

However, the Lions have won five of the last six meetings including sweeping the Bears last season.

Chicago Bears vs. Detroit Lions Predictions

This will be Detroit’s home opener and I expect the stadium to be rocking. And, it also marks Chicago’s new head coach Ben Johnson’s return to the city of Detroit. While, I’m sure he will get an ovation before the game, you can expect the Detroit fans to boo him during the game.

With that said, the Lions are still the best of the division and I expect this offense to operate like the juggernaut it’s been over the last few years. I also see a renewed defensive intensity that will help limit Chicago’s new offense.

Bet: Detroit Lions (-218), Lions -4.5 (-110)

New England Patriots vs. Miami Dolphins Odds

An early AFC East matchup could clear up some questions as to which team is really the second best in the division behind Buffalo.

The Miami Dolphins hold an advantage in this divisional rivalry with a 64-55 record. They’ve also dominated the New England Patriots over the last handful of years as Miami has gone 8-1 in the last nine meetings. This includes winning four in arow and two straight years of sweeping New England.

Last year, Miami outscored New England 49 to 25 in their two meetings. Additionally, the Dolphins have won five straight home games over the Patriots.

New England Patriots vs. Miami Dolphins Predictions

Miami has lost more talent than they’ve added. The Patriots have added more talent than they’ve lost. In fact, I think that New England could be sneaky good this season under new coach Mike Vrabel and second-year QB Drake Maye. Just keep Diggs away from boats.

Bet: New England Patriots (+120), Patriots +2.5 (-110)

San Francisco 49ers vs. New Orleans Saints Odds

The San Francisco 49ers head out on the road for a second consecutive week. However, this matchup appears to be much easier on paper as the New Orleans Saints are in rebuild mode.

The 49ers hold a massive lead in the series with a 50-27-2 record. They’ve also won three of the last five meetings.

San Francisco 49ers vs. New Orleans Saints Predictions

Although both teams lost some key players, the 49ers still have enough superstars on both sides of the ball to beat the Saints by at least a touchdown. Take San Francisco to pick up an easy win in the “Big Easy.”

Also, I don’t see the Saints scoring many points early in the season due to playing subpar quarterbacks behind subpar offensive lines. So, take the Under.

Bet: San Francisco 49ers (-355), 49ers -7 (-110), Under 44.5 (-110)

Buffalo Bills vs. New York Jets Odds

The Buffalo Bills are the biggest road betting favorite in Week 2 as they head to Jersey to battle the rebuilding New York Jets.

Buffalo has gone 9-3 versus the Jets in their last 12 meetings. The Bills also swept New York last year including a 40-14 thrashing in their second game for last season.

Buffalo Bills vs. New York Jets Predictions

The Buffalo Bills are Super Bowl contenders, while the Jets are rebuilding under new head coach Aaron Glenn. Take Josh Allen and company to win this game by at least two touchdowns. I also see the Over hitting as Buffalo scores 30+ points in this matchup.

Bet: Buffalo Bills (-395), Bills -8.5 (-110), Over 44.5 (-110)

Seattle Seahawks vs. Pittsburgh Steelers Odds

There’s a little extra drama building up for this game as new Pittsburgh Steelers no.1 wide receiver DK Metcalf takes on the team that drafted and traded him – Seattle Seahawks.

This game marks the 22^nd time that these two franchises have played against each other. Pittsburgh has the slight advantage with an 11-10 record in this series.

The Steelers have won five of the last seven meetings including two in a row. The last time these teams played against each other was on New Year’s Eve of 2023. Pittsburgh won in Seattle by the score of 30-23.

Pittsburgh is 4-1 in their last five home games versus Seattle and 9-3 all-time at home against the Seahawks.

Seattle Seahawks vs. Pittsburgh Steelers Predictions

This game also features two new no.1 quarterbacks as Seattle traded Geno Smith to the Raiders and signed Sam Darnold in the offseason. The Steelers just added Aaron Rodgers after months of speculation.

Both teams have undergone changes offensively, which might take each squad time to really hit their stride. So, if we look at the defenses, you have to give the advantage to Pittsburgh. Take the Steel-Curtain to win at home in Week 2.

Bet: Pittsburgh Steelers (-125), Steelers -1.5 (-110)

Los Angeles Rams vs. Tennessee Titans Odds

The Los Angeles Rams and Tennessee Titans have played against each other 14 times. However, none were bigger than their Super Bowl 34 matchup where the Rams stopped the Titans one yard shy of winning the game.

Los Angeles holds the series advantage with an 8-6 record. Yet, the Titans have won three of the last four matchups including their most recent game in 2021. Surprisingly, the Rams hold a 5-3 all-time record on the road in this series.  

Los Angeles Rams vs. Tennessee Titans Predictions

If I had to pick an early front runner for the NFC West, I would take the Los Angeles Rams. This team lost a tough, bad-weather game at Philly last postseason, but had a chance late in the game to take the lead. They’ve added players like Davante Adams, and their young defense will be even better.

The Tennessee Titans have the #1 pick of the 2025 NFL Draft in Cam Ward who will get shellacked by the Rams defense.  

LA wins this game by at least a touchdown!

Bet: Los Angeles Rams (-225), Rams -5.5 (-110)

Carolina Panthers vs. Arizona Cardinals Odds

This NFC clash marks the 22^nd time that these two teams have played against each other. Currently, the Carolina Panthers hold a 15-6 advantage over the Arizona Cardinals.

Additionally, the Panthers have won seven of the last eight meetings in this series including the last two games at Arizona.

Carolina Panthers vs. Arizona Cardinals Predictions

History is on Carolina’s side in this matchup, but I have a hard time believing that trend will continue. At this point in time, there are far more question marks surrounding the Panthers than the Cardinals. I see Arizona protecting their home turf as Kyler Murray outduels Bryce Young.

Bet: Arizona Cardinals (-205), Cardinals -4.5 (-110)

Denver Broncos vs. Indianapolis Colts Odds

This Week 2 contest marks the 31^st time that these two teams have met. Currently, each team has won 15 games apiece. Yet, the Denver Broncos have taken three of the last four.

The Indianapolis Colts are 10-6 in home games against the Broncos and have won seven of the last eight meetings at home.

Denver Broncos vs. Indianapolis Colts Predictions

The only area where the Colts have an advantage over the Broncos is in the backfield with running back Jonathan Taylor. Otherwise, the Broncos have a far better defense and second-year QB Bo Nix is far better than any QB that starts for the Colts.

Elite defenses travel well and the QB advantage tends to lead to victories. Take the Broncos to win this game by at least four points.

Bet: Denver Broncos (-175), Broncos -3.5 (-110)

Philadelphia Eagles vs. Kansas City Chiefs Odds

In a rematch from Super Bowl 59, the Philadelphia Eagles head to Arrowhead Stadium to battle the Kansas City Chiefs. This game is the marquee matchup of Week 2.

The series is tied 6-6 and both teams have won a Super Bowl against the other. KC won Super Bowl 57 over the Eagles.

In another surprise, it’s the Eagles who hold the advantage when games are played at Arrowhead. Philly has a 4-2 all-time record at KC and have won three of the last four.

Philadelphia Eagles vs. Kansas City Chiefs Predictions

Although the Chiefs remain the odds-on favorite to win the AFC Championship, the Eagles remain the better team on paper and on the field.

KC opens up the season in Brazil against the Chargers. Philly will get three extra days to prepare for this game and one extra day than the Chiefs. I like the Birds to soar to victory in Kansas City.

Bet: Philadelphia Eagles (+100), Eagles +1.5 (-110), Over 45.5 (-110)

Atlanta Falcons vs. Minnesota Vikings Odds

Week 2’s Sunday Night Football game features two teams looking to take the next step by winning their respective divisions.

The Minnesota Vikings came close last year, but fell one game short to the Lions in the NFC North. The Atlanta Falcons came up one game short to the Buccaneers for the NFC South crown. While Minnesota still made the Playoffs as a Wild Card team, the Falcons stewed all off-season long about missing the postseason.

This game marks the 35^th time that these two NFC teams have played against each other. The Vikings hold a commanding lead with a 22-12 all-time record. Minnesota has also won six of the last seven head-to-head meetings.

Atlanta Falcons vs. Minnesota Vikings Predictions

I think this game comes down to the QB play between second-year quarterbacks: Penix (Falcons) and McCarthy (Vikings).

I’m not a big believer in McCarthy, but I liked what I saw from Penix in his limited action last year. Take the Dirty Birds to win at home in Week 2.

Bet: Atlanta Falcons (+170), Falcons +4.5 (-110)

Tampa Bay Buccaneers vs. Houston Texans Odds

The first of two Monday Night Football games features the NFC South winner Tampa Bay Buccaneers traveling to Texas to face the AFC South winner Houston Texans.

The Bucs and Texans have played against each other six times. The Texans hold a commanding 5-1 lead in the series and have won five in a row. There last meeting came in 2023, and the Texans nipped the Bucs 39 to 37 at home. Houston is 3-0 in home games versus the Bucs.

Tampa Bay Buccaneers vs. Houston Texans Predictions

This is also the home opener for the Texans as they play at the Rams in Week 1. The Bucs will play their second road game to start off the season. This could play a part in Tampa’s success since they battle Atlanta in Week 1, which would be a far more emotional contest than this one.

I think Houston has done more than enough to be considered one of the top teams in the AFC and they will show it by beating the Bucs on MNF. Houston’s never lost at home to Tampa Bay and I don’t expect it to start now.

Bet: Houston Texas (-125), Texans -1.5 (-110)

Los Angeles Chargers vs. Las Vegas Raiders Odds

In the final game of Week 2, long-time AFC West rivals the Los Angeles Chargers and Las Vegas Raiders will meet for the 132^nd time.

The Raiders hold an advantage with a 69-60-2 record. The Chargers have won three of the last four games including sweeping the Raiders last season. Yet, we still can’t forget that massive demolishing that the Raiders laid on the Chargers in late 2023, when Las Vegas won 63 to 21.

Los Angeles Chargers vs. Las Vegas Raiders Predictions

I’m slightly surprised that the lines are this close. That means there’s still value with the Chargers who I believe are the better team.

They have the better quarterback and have improved their roster from last season. The Raiders are retooling the roster and I don’t see much success this season.

Bet: Los Angeles Chargers (-155), Chargers -3 (-110)

NFL Week 2 Best Bets

The following is our best bets for NFL Week 2:

• Denver Broncos (-175)
• Buffalo Bills (-395)
• Philadelphia Eagles +1.5 (-110)

The Broncos are the more complete team than the Colts and they have huge advantages on defense along with the QB position. I expect Denver to force whichever subpar QB starts, to beat them via the air, which won’t happen.

The Buffalo Bills are superior than the Jets in every category except no.1 wide receiver. The Jets are rebuilding and the Bills will use this game to pad their record.

I’m taking the Eagles spread for now, but I think they win this game outright in a Super Bowl rematch. Philly has the better roster.

If you take all three of these best bets for Week 2, and add them to an NFL parlay, then you will earn $276 in winnings on a $100 bet.

After this, share a sentence or two on these bets. Then say how much they could make on a parlay with $100 wager.