Week 12 of the 2025–26 NFL season kicks off with a Thursday night AFC showdown as the Houston Texans host the Buffalo Bills in a primetime matchup featuring two teams battling for playoff position.

Sunday’s action begins with a full slate at 1 p.m. ET, highlighted by the Detroit Lions hosting the New York Giants, the Tennessee Titans welcoming the Seattle Seahawks, and the Baltimore Ravens facing the New York Jets.

In the late afternoon window, playoff implications ramp up as the Dallas Cowboys square off with the Super Bowl champion Philadelphia Eagles, the Las Vegas Raiders take on the Cleveland Browns, and the Arizona Cardinals get a visit from the Jacksonville Jaguars.

Week 12 wraps on Monday Night Football with the San Francisco 49ers hosting the Carolina Panthers in a cross-conference meeting with potential NFC playoff seeding on the line.

The Denver Broncos, Miami Dolphins, Los Angeles Chargers, and Washington Commanders are the only NFL teams on byes this week.

Let’s dive into the NFL Week 12 odds from top online sportsbooks and begin breaking down every matchup with our Week 12 picks.

NFL Week 12 Schedule

NFL Week 12 Odds

As we dive into the early Week 12 NFL odds, there are a few notable betting lines that jump off the page at the top online sportsbooks.

The Bucs vs. Rams matchup features one of the higher totals of the week in a matchup between a couple of the league’s most explosive offenses. Several other games sit in the mid-40s range, with a handful hovering between 45.5 and 47.5, depending on the book. Weather shouldn’t be a major factor in most locations this weekend, but always double-check before locking in totals. Also, don’t forget to check out our top player prop bets of the week as well.

The 49ers are among the biggest favorites on the board, laying a touchdown at home against the Panthers. There are also multiple spreads sitting between 3 and 6 points, which creates some appealing opportunities for Underdogs and teaser players heading into the holiday slate.

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NFL Week 12 Predictions

Let’s take a look at the full slate of NFL Week 12 matchups and make our NFL picks for each game.

Buffalo Bills vs. Houston Texans Odds

The Buffalo Bills come into this matchup fresh off a 44-point outburst against Tampa Bay, and Josh Allen looked sharp from start to finish. He threw for 317 yards with three touchdowns and didn’t take a sack, which gave the offense breathing room on every drive. When Buffalo protects like that, the ball usually moves without much resistance.

The Houston Texans got a win in Tennessee, but the offense leaned heavily on Davis Mills since C.J. Stroud is still in concussion protocol. Mills threw for 274 yards while Nico Collins and Jayden Higgins carried most of the receiving work. The run game never settled in, which left Mills to shoulder more volume than ideal.

The Texans’ defense kept Tennessee in check, but the challenge gets tougher against Buffalo’s vertical passing. The Bills have multiple receivers who can win down the field, and their tempo is a problem when they start stacking chunk plays. If Houston struggles to get pressure, Allen will find space.

Houston should stay competitive for stretches because Mills has been steady, but the ceiling isn’t the same without Stroud. Buffalo is playing faster and cleaner, and the pass game looks dangerous again. The Texans can hang around, but asking them to match drives with the Bills for four quarters is a stretch.

Buffalo Bills vs. Houston Texans Predictions

• Spread: Bills -6.5 (–115)
Buffalo’s passing attack is rolling, and Houston doesn’t have the firepower to keep pace over four quarters.

• Total: Over 43.5 (–115)
The Bills can push this number on their own if they start fast, and Houston should score enough in catch-up mode to help.

• Moneyline: Bills (–265)
Buffalo has the stronger quarterback, cleaner protection, and a better chance to control the tempo from the start.

Bet: Bills ML (–265), Bills -6.5 (–115), Over 43.5 (–115)

New York Giants vs. Detroit Lions Odds

The New York Giants fell 27-20 against the Green Bay Packers and played a clean game on offense despite coming up short. Jameis Winston threw for 201 yards with no turnovers, and the ground game added 142 yards behind Tyrone Tracy Jr. and Devin Singletary. The Giants struggled to generate explosive plays, which kept them from building momentum in the second half.

The Detroit Lions dropped a tough road game in Philadelphia, scoring only nine points against a defense that won the line of scrimmage. Jared Goff threw for 255 yards but needed 37 attempts, and the offense never found a rhythm until late. The run game produced only 39 yards from Jahmyr Gibbs, which stalled several drives.

This matchup should lean toward Detroit because the Lions are a different team at home and usually play faster on their own field. The Giants can run the ball well, but falling behind early would force Winston into heavier volume, which limits their scoring ceiling. Detroit has more ways to create downfield pressure and should find better production compared to what they managed in Philadelphia.

The Giants can keep this close if Tracy Jr. gets going early, although Detroit’s front seven is strong enough to make running lanes tight. Goff should settle in quicker in this spot since New York has had trouble containing precision passing attacks. If the Lions finish drives, they should control the game through all four quarters.

New York Giants vs. Detroit Lions Predictions

• Spread: Giants +10.5 (–110)
New York can run the ball well enough to slow the pace and stay inside a large number.

• Total: Over 48.5 (–115)
Detroit should bounce back on offense, and Winston’s group can contribute enough scoring to push this over.

• Moneyline: Lions (–550)
Detroit is stronger on both lines and has the more reliable quarterback in a controlled home environment.

Bet: Lions ML (–550), Giants +10.5 (–110), Over 48.5 (–115)

Seattle Seahawks vs. Tennessee Titans Odds

The Seattle Seahawks dropped a tight one to the Los Angeles Rams, but the offense still moved the ball well through the air. Sam Darnold threw for 279 yards, and Jaxon Smith-Njigba led the team with 105 receiving yards on nine catches. The Seahawks struggled to finish drives, which kept them from taking control in the second half.

The Tennessee Titans stayed close with Houston but never fully found its footing on offense. Cam Ward threw for 194 yards with one touchdown, although the ground game totaled only 58 yards, which made sustaining long drives a challenge. The Titans continue to rely on short passing and timely defense, but explosive production remains limited.

This matchup leans heavily toward Seattle because the Seahawks have a sharper passing attack and more reliable playmaking at receiver. Tennessee has been scrappy, though the offense often needs perfect drives to stay in a game, and that leaves little room for errors. Seattle should find more balance here since the Titans have struggled to contain perimeter speed.

The Titans can keep this interesting if Ward pushes the ball downfield early, but Seattle’s defense usually tightens up once teams fall into predictable passing situations. Kenneth Walker III and Zach Charbonnet should also help Seattle stay ahead of the chains. If the Seahawks avoid turnovers, they should control the flow from the start.

Seattle Seahawks vs. Tennessee Titans Predictions

• Spread: Titans +13.5 (–115)
Tennessee kept its last game within three points and showed enough passing production to stay inside this number.

• Total: Under 40.5 (–115)
Tennessee’s offense stalls often, and Seattle’s style can slow the pace when they lean on the run.

• Moneyline: Seahawks (–850)
Seattle has more dependable weapons, and Tennessee lacks the scoring output to threaten late.

Bet: Seahawks ML (–850), Titans +13.5 (–115), Under 40.5 (–115)

New England Patriots vs. Cincinnati Bengals Odds

The New England Patriots picked up a 27-14 win over the New York Jets, and Drake Maye threw for 281 yards on 25 completions. Stefon Diggs led the receivers with 105 yards, and the offense added 65 rushing yards with TreVeyon Henderson handling most of the carries. The defense recorded four interceptions, which gave Maye short fields and helped the Patriots take control early.

The Cincinnati Bengals struggled in its 34-12 loss to the Pittsburgh Steelers, and Joe Flacco finished with 199 yards, one touchdown, and one interception. He took seven sacks, and the offense produced only one touchdown despite 99 rushing yards from Chase Brown. Tee Higgins was the top target with 63 receiving yards, but the Bengals never gained momentum.

The Patriots were sharper in both phases, and their passing game created more consistent gains. Their defense also kept the Jets to 116 passing yards, which stands out compared to the yards Cincinnati gave up to Pittsburgh. With Flacco continuing to start for the injured Joe Burrow, Cincinnati enters this matchup with similar challenges to last week.

New England’s balance on offense makes this a favorable matchup since they showed efficient passing and steady rushing production. Cincinnati will need bigger plays than it generated against Pittsburgh to stay close. New England has the cleaner profile heading into Week 12.

New England Patriots vs. Cincinnati Bengals Predictions

• Spread: Patriots -8.5 (–115)
New England just won by 13 while Cincinnati lost by 22, and the Patriots posted far more passing production.

• Total: Under 50.5 (–110)
Both teams played games that finished below this mark, and neither offense piled up touchdowns last week.

• Moneyline: Patriots (-330)
The Patriots protected the ball and created turnovers, and Cincinnati struggled in protection with seven sacks allowed.

Bet: Patriots ML (-330), Patriots -8.5 (-115), Under 50.5 (-110)

New York Jets vs. Baltimore Ravens Odds

The New York Jets are coming off a 27-14 loss to the New England Patriots, where Justin Fields threw for 116 yards with one touchdown and four interceptions. The Jets ran for 140 yards with Breece Hall leading the way at 58 yards on 14 carries, and John Metchie III produced 45 receiving yards on three catches. The turnovers swung the game early, and the Jets couldn’t recover despite decent production on the ground. This week, New York will start veteran Tyrod Taylor over Fields.

The Baltimore Ravens picked up a 23-16 win over the Cleveland Browns, and the offense leaned on the run with 183 rushing yards as a team. Derrick Henry set the tone with 103 yards and a touchdown on 18 carries, and Lamar Jackson added 25 rushing yards to keep drives moving. The passing game was quieter with 193 yards and two interceptions, but Zay Flowers led the receivers with 78 yards.

The Ravens’ strong rushing output stands out in this matchup since the Browns allowed only 105 rushing yards the week before. Baltimore also produced multiple explosive plays on the ground, including runs of 59 and 35 yards, which helped keep them ahead late. The Jets will need more consistency from the passing game after averaging 4.5 yards per attempt against New England.

New York can stay competitive if Hall finds space early, though the turnovers last week limited how often they could stay on schedule. Baltimore’s ability to generate chunk plays gives them an advantage, and their defense held Cleveland under 140 passing yards and 42 rushing yards. Baltimore brings more steady production into Week 12.

New York Jets vs. Baltimore Ravens Predictions

• Spread: Jets +13.5 (–110)
The Jets ran for 140 yards last week and have enough ground production to keep this inside a big number.

• Total: Under 44.5 (–112)
Both teams played games that ended below this mark, and neither offense produced steady passing gains.

• Moneyline: Ravens (–800)
Baltimore generated the stronger rushing output and controlled its game more consistently than New York.

Bet: Ravens ML (–800), Jets +13.5 (–110), Under 44.5 (–112)

Indianapolis Colts vs. Kansas City Chiefs Odds

The Indianapolis Colts enter this matchup off their overtime win against the Atlanta Falcons two weeks ago in Germany. Daniel Jones threw for 196 yards with one touchdown and one interception, and the offense piled up 323 rushing yards on 41 carries. Jonathan Taylor led the way with 244 rushing yards and two touchdowns, including a long run of 83 yards that changed the game. Tyler Warren and Alec Pierce combined for 172 receiving yards, which helped balance the attack.

The Kansas City Chiefs are coming off a 22-19 loss to the Denver Broncos, and Patrick Mahomes threw for 276 yards with one touchdown and one interception. The Chiefs ran for 62 yards on 14 attempts, and Travis Kelce posted 91 receiving yards on nine catches. Hollywood Brown and Rashee Rice added steady production, although Kansas City settled for field goals on multiple drives. Their defense allowed 283 passing yards and 59 rushing yards.

Indianapolis brings the stronger rushing performance into this matchup after putting up 7.9 yards per carry against Atlanta. The Colts also showed the ability to stretch the field with big plays from Taylor and multiple 20-yard receptions from Warren and Pierce. Kansas City’s pass game was productive, but the offense struggled to convert yards into touchdowns against Denver.

The Chiefs can lean on Kelce and their quick passing game, though the Colts’ balanced output in Germany gives them momentum going into this week. Daniel Jones played a clean game outside of one interception, and the run game created steady chunk plays. Both teams moved the ball well in their last appearances, but Indianapolis showed more finishing power inside the red zone.

Indianapolis Colts vs. Kansas City Chiefs Predictions

• Spread: Colts +3.5 (–115)
Indianapolis showed strong scoring ability with 31 points and multiple long gains on the ground.

• Total: Over 50.5 (–108)
Both offenses produced over 250 total yards and had multiple explosive plays in their last games.

• Moneyline: Chiefs (-175)
Kansas City had steady passing production with Mahomes spreading the ball to several targets.

Bet: Chiefs ML (-175), Colts +3.5 (-115), Over 50.5 (-108)

Minnesota Vikings vs. Green Bay Packers Odds

The Minnesota Vikings are coming off a 19-17 home loss to the Chicago Bears, where J.J. McCarthy struggled, throwing for 150 yards with one touchdown and two interceptions. Minnesota ran the ball well with Aaron Jones Sr. and Jordan Mason combining for 115 rushing yards on 22 carries, but the offense stalled in key spots.

The Green Bay Packers just beat the New York Giants 27-20 at home behind a balanced attack. Jordan Love threw for 174 yards and two touchdowns while Malik Willis added a 66-yard scoring strike in limited work. Green Bay also rushed for 128 yards and three touchdowns, leaning on Emanuel Wilson and Josh Jacobs.

On the other side of the ball, the Packers limited the Giants to 201 passing yards and picked off Jameis Winston twice. Green Bay did give up 142 rushing yards on 38 carries, so gap control against Aaron Jones Sr. and Jordan Mason remains a real concern. The Vikings defense just allowed 140 rushing yards to Chicago and gave up only one passing touchdown, but they failed to come up with a takeaway.

Jacobs will miss this game with a knee injury, so Green Bay will likely lean more on Emanuel Wilson and the rest of the committee. With Love spreading the ball to Romeo Doubs, Christian Watson, and several secondary targets last week, the Packers still have enough firepower through the air. If McCarthy again turns the ball over and Minnesota cannot finish drives, Green Bay is set up to control the game in front of its home crowd.

Minnesota Vikings vs. Green Bay Packers predictions

Moneyline: Packers -285 – With the better form, home field edge, and the Vikings coming off a close loss where the offense left points on the field, Green Bay is the safer side on the moneyline.

Spread: Packers -6.5 (-110) – Green Bay just won by seven over the Giants with a strong passing and rushing mix, while Minnesota lost by two at home with McCarthy throwing two interceptions.

Total: Under 40.5 (-105) – Both defenses just held opponents under 20 points, and each offense leaned on the run, which points to a slower game that can stay under this number.

Bet: Packers ML (-285), Packers -6.5 (-110), Under 40.5 (-105)

Pittsburgh Steelers vs. Chicago Bears Odds

The Pittsburgh Steelers are coming off a 34-12 win over the Cincinnati Bengals, where Mason Rudolph stepped in after Aaron Rodgers injured his non-throwing hand and went 12-of-16 for 127 yards and two touchdowns. Pittsburgh also ran for 111 yards on 28 carries, getting chunk plays from Jaylen Warren and Kenneth Gainwell to help support their backup quarterback. The Steelers’ defense picked off Joe Flacco once, forced two sacks, and held Cincinnati to 105 rushing yards.

The Chicago Bears edged the Minnesota Vikings 19-17 on the road last week behind a strong defensive showing. Caleb Williams threw for 193 yards with no touchdowns and one interception, while Chicago’s ground game leaned on D’Andre Swift for 90 yards on 21 carries. The Bears allowed only 150 passing yards to J.J. McCarthy and came up with an interception and multiple key stops in the fourth quarter.

Chicago held Minnesota to just 17 points and limited the Vikings to 115 rushing yards on 22 attempts, but their pass rush didn’t generate consistent pressure. Pittsburgh enters this matchup having produced explosive passing plays even with Rudolph under center, and Warren’s 62-yard run last week shows they can break open drives on the ground. With Rodgers unlikely to go, Pittsburgh’s offense again projects to revolve around short throws, play-action, and a committee rushing approach.

The Steelers’ defense has also improved, keeping the Bengals out of the end zone until late and holding them to just 12 points overall. Chicago’s offense moved the ball well last week but finished only one of its trips with a passing touchdown, and Williams’ accuracy was inconsistent down the stretch. If Pittsburgh gets a similar defensive effort and Rudolph avoids turnovers, the Steelers should be able to keep this tight in the fourth quarter.

Pittsburgh Steelers vs. Chicago Bears predictions

Moneyline: Steelers +135 — With Chicago’s offense struggling to finish drives and Pittsburgh showing more explosiveness last week, the Steelers offer better value on the moneyline.

Spread: Steelers +3 (-110) — Pittsburgh just won convincingly with Rudolph under center, and their balanced offense should allow them to stay within a field goal here.

Total: Over 44.5 (-110) — Both teams ran the ball effectively last week and generated multiple explosive gains, putting this total within reach.

Bet: Steelers ML (+135), Steelers +3 (-110), Over 44.5 (-110)

Jacksonville Jaguars vs. Arizona Cardinals Odds

The Jacksonville Jaguars are coming off a 35–6 blowout of the Los Angeles Chargers, where Trevor Lawrence went 14-of-22 for 153 yards with one touchdown and one interception while avoiding any sacks behind a clean pocket. Jacksonville also piled up 192 rushing yards on 47 carries, led by Bhayshul Tuten and Travis Etienne Jr. combining for 147 yards and three scores. That kind of balanced effort gives them options on the road.

The Arizona Cardinals just took a 41–22 loss to the San Francisco 49ers, and Jacoby Brissett set an NFL record with 47 completions for 452 yards, two touchdowns, and two interceptions. The Cardinals’ ground game only produced 36 rushing yards on 14 carries, so nearly all of their offense came through the air. That high-volume passing script showed both upside and turnover risk.

San Francisco’s offense had little trouble moving the ball, with Brock Purdy throwing three touchdowns and Christian McCaffrey scoring twice on the ground. Arizona’s defense gave up 200 receiving yards to the 49ers’ pass catchers and 95 rushing yards, which now gets tested again by a Jaguars attack that just hit explosive plays on both fronts. Jacksonville should be able to probe the same soft spots if they stay on schedule.

Jacksonville looks like the more complete side while Arizona leans on Brissett’s arm to keep pace. If the Jaguars’ run game repeats anything close to last week’s success and Lawrence protects the ball, they are in a good spot to control tempo and field position. That sets the tone for how we approach this market.

Jacksonville Jaguars vs. Arizona Cardinals predictions

Moneyline: Jaguars -148. Jacksonville brings the stronger run game and a defense that just held the Chargers to six points, which makes the favorite the safer side to win outright.

Spread: Jaguars -2.5 (-115). With the Jaguars winning by 29 last week and Arizona coming off a 19-point loss where the defense struggled at every level, laying less than a field goal with Jacksonville is reasonable.

Total: Over 47.5 (-108). Brissett’s 452-yard outing and the Jaguars’ 35-point explosion suggest both offenses can create chunk plays, so this game has a clear path to clearing the mid-40s total.

Bet: Jaguars ML (-148), Jaguars -2.5 (-115), Over 47.5 (-108)

Cleveland Browns vs. Las Vegas Raiders Odds

The Cleveland Browns just fell 23–16 at home to the Baltimore Ravens in a game where their quarterbacks combined to go 11-of-26 for 81 yards with two touchdowns and two interceptions. Cleveland leaned on the run with 106 rushing yards on 25 carries, but the offense never fully opened up through the air. With Dillon Gabriel in concussion protocol and Shedeur Sanders waiting in the wings, the Browns could again ride the ground game while sorting out the quarterback spot.

The Ravens had success on the ground with 184 rushing yards on 30 attempts, including 103 yards and a score from Derrick Henry, and Lamar Jackson added 193 passing yards despite throwing two interceptions. That performance shows the Browns’ defense can be stressed by a power run game that keeps the chains moving. If Cleveland faces a similar script, their offense may need to play from behind.

The Las Vegas Raiders are coming off a 33–16 loss to the Dallas Cowboys, where Dak Prescott threw for 268 yards and four touchdowns and the Cowboys added 114 rushing yards on 31 carries. Las Vegas managed 209 passing yards and a single touchdown from Geno Smith on 42 attempts, while the run game produced only 27 yards on 12 carries. The Raiders moved the ball through the air in spurts but struggled to match Dallas drive for drive.

Even with that loss, the Raiders’ passing numbers look stronger than what Cleveland showed against Baltimore, and home field now shifts to Allegiant Stadium. If Gabriel is limited or out and Sanders has to make his first NFL start, the Browns may again rely on short throws and the run, which can keep the pace slow but makes it tougher to match a competent Raiders passing attack.

Cleveland Browns vs. Las Vegas Raiders predictions

Moneyline: Raiders -170: With more stability at quarterback and home field in their favor, the Raiders are the pick to win this matchup outright.

Spread: Raiders -3 (-118): Cleveland’s recent offensive struggles and uncertain quarterback situation tilt this number toward Las Vegas covering a field goal at home.

Total: Under 36.5 (-110): Both defenses just held opponents under 24 points and the Browns are leaning run heavy, which points to a lower scoring game that can stay below this modest total.

Bet: Raiders ML (-170), Raiders -3 (-118), Under 36.5 (-110)

Philadelphia Eagles vs. Dallas Cowboys Odds

The Philadelphia Eagles are fresh off a 16–9 home win over the Detroit Lions where Jalen Hurts threw for 135 yards and ran for 31 yards and a touchdown. Saquon Barkley handled 26 carries for 83 yards and the Eagles leaned on their defense and field position. Detroit managed just nine points despite 255 passing yards and 74 rushing yards.

The Dallas Cowboys just beat the Las Vegas Raiders 33–16 on the road behind 268 passing yards and four total touchdowns from Dak Prescott. The Cowboys ran the ball 31 times for 114 yards, with Javonte Williams leading the way at 93 rushing yards and a score. The passing game spread the ball to George Pickens, CeeDee Lamb and the rest of the receivers for 268 yards and one touchdown.

Defensively, the Eagles held an explosive Detroit offense to 255 passing yards and only one trip to the end zone, adding 135 receiving yards allowed on 14 catches with no scores to the wideouts or tight ends. The Cowboys limited Las Vegas to 209 passing yards and 27 rushing yards and picked up four sacks on Geno Smith. Both front sevens showed up, which matters in a matchup with two aggressive quarterbacks.

Philadelphia brings a multi-game winning streak into this rivalry spot, and their latest win fits that profile, even if it was not flashy. Dallas will have the more explosive passing numbers from last week, but the Eagles have the stronger recent defensive resume and a rushing attack that can control tempo. That combination gives Philadelphia a small edge even in a loud road environment.

Philadelphia Eagles vs. Dallas Cowboys predictions

Moneyline: Eagles -198 – Philadelphia just held Detroit to nine points while Dallas faced a struggling Raiders offense, so I lean toward the Eagles’ more proven defense and balanced attack to steal this one in Arlington.

Spread: Eagles -3.5 (-110) – With Barkley handling 26 carries and Hurts adding 31 rushing yards, the Eagles have the ground game to grind out drives and cover a number just over a field goal.

Total: Under 48.5 (-112) – Recent finals of 16–9 and 33–16 plus two defenses that just kept opponents under 20 points point me toward a slightly lower scoring game than this high total suggests.

Bet: Eagles ML (-198), Eagles -3.5 (-110), Under 48.5 (-112)

Atlanta Falcons vs. New Orleans Saints Odds

The Atlanta Falcons are coming off a 30–27 overtime loss to the Carolina Panthers that showcased both their offensive upside and defensive issues. Atlanta rushed 28 times for 125 yards with Bijan Robinson accounting for 104 yards and two scores, while the passing game produced 223 yards and two touchdowns between Michael Penix Jr. and Kirk Cousins. The problem was on defense, where the Falcons allowed 419 passing yards and 67 rushing yards, including 130 receiving yards to Tetairoa McMillan.

The New Orleans Saints return from their bye after a 34–10 loss to the Los Angeles Rams in Week 10. The Saints threw for 167 yards on 25 attempts and rushed for only 57 yards on 14 carries, managing just one offensive touchdown. Defensively they surrendered 281 passing yards and four touchdowns to Matthew Stafford, and 114 rushing yards on 25 carries to Kyren Williams.

Atlanta’s offensive identity is clear with Robinson and Tyler Allgeier combining for 37 touches and 179 scrimmage yards against Carolina. If Kirk Cousins draws the start for an injured Penix, the Falcons will lean on his experience to keep the passing game on schedule while the backs handle the heavy lifting. The concern is on the other side of the ball, where Atlanta just allowed 8.2 yards per attempt and 31 receptions to Panthers receivers and tight ends.

The Saints’ offense has been more conservative, with Taysom Hill and Alvin Kamara sharing the workload on the ground and Chris Olave leading the receiving group. Against the Rams, New Orleans averaged 4.1 yards per carry and 6.7 yards per attempt, but third-down execution and explosive plays were limited. Coming out of the bye, the Saints will aim to sharpen those details while relying on a defense that has flashed playmaking ability despite giving up big numbers to Stafford and Williams a couple of weeks ago.

Atlanta Falcons vs. New Orleans Saints predictions

Total: Over 39.5 (-108) – Both defenses just allowed 30 or more points in their last outings and each offense has enough playmakers to push this into the low 40s.

Moneyline: Saints -130 – New Orleans gets this matchup at home off a bye against a Falcons defense that just allowed 486 total yards and 30 points.

Spread: Saints -1.5 (-115) – With Atlanta’s defense giving up 400-plus yards through the air in Germany, a narrow home win by the Saints is a reasonable expectation.

Bet: Saints ML (-130), Saints -1.5 (-115), Over 39.5 (-108)

Tampa Bay Buccaneers vs. Los Angeles Rams Odds

The Tampa Bay Buccaneers just dropped a 44–32 shootout in Buffalo, where Baker Mayfield threw for 173 yards with two touchdowns and one pick while the offense piled up 202 rushing yards behind Sean Tucker’s 106 and two scores. That performance showed a real spark on the ground, but the defense was roasted for 317 passing yards and three touchdowns by Josh Allen. Tampa Bay now has to fly west for a night game against a Rams team that leans on a balanced attack.

The Los Angeles Rams coming off a tight 21–19 home win over the Seattle Seahawks in which Matthew Stafford attempted only 28 passes for 130 yards but tossed two touchdowns. Kyren Williams gave them steady production with 91 rushing yards on 12 carries and a score, while Puka Nacua caught seven balls for 75 yards and a touchdown. The Rams defense held Seattle out of the end zone through the air and limited the Seahawks to one rushing touchdown and 19 total points.

This matchup sets up as a contrast between Tampa Bay’s sudden run game and a Rams front that just held Seattle to 135 rushing yards on 35 attempts. If Sean Tucker and Rachaad White can keep the chains moving, Mayfield should have enough play-action chances to target Sterling Shepard and the rest of his receivers downfield. On the other side, Stafford, Nacua, and Williams get a favorable draw against a Buccaneers defense that just surrendered nine yards per pass attempt and three touchdown passes.

This feels like a game where both offenses can move the ball but the Rams have the cleaner path to success at home. Tampa Bay’s defense has not shown it can hold up against efficient passing attacks, while Los Angeles just proved it can finish drives in the red zone and protect a lead late. The spread is hefty, yet the combination of Rams passing efficiency and a solid home field makes them the safer side.

Tampa Bay Buccaneers vs. Los Angeles Rams predictions

Moneyline: Rams -305 – Los Angeles is at home, just beat a solid Seattle team, and faces a Buccaneers defense that allowed 44 points and 317 passing yards in Buffalo.

Spread: Rams -6.5 (-115) – With Stafford finding Nacua and Williams running well, the Rams are capable of winning this by more than a touchdown if Tampa Bay’s secondary plays like it did last week.

Total: Over 48.5 (-108) – The Buccaneers just played a 76-point game, and both offenses have recent evidence of explosive plays, so a shootout is firmly in range for Sunday night.

Bet: Rams ML (-305), Rams -6.5 (-115), Over 48.5 (-108)

Carolina Panthers vs. San Francisco 49ers Odds

The Carolina Panthers roll into this matchup off a 30–27 overtime win in Atlanta where Bryce Young piled up 448 passing yards on 31-of-45 attempts with three touchdowns. Carolina’s receivers had a field day, with Tetairoa McMillan catching 8 balls for 130 yards and Xavier Legette adding 83 yards and a score. Even with that production through the air, the Panthers ran it often enough for 67 rushing yards and two touchdowns from Rico Dowdle. It was an explosive offensive showing, but they still needed extra time to escape with a three-point win.

The San Francisco 49ers are coming off a 41–22 road victory over Arizona where Brock Purdy turned in an efficient 19-of-26, 200-yard, three-touchdown passing line without an interception. Christian McCaffrey once again drove the ground game with 81 rushing yards and two scores on 13 carries while also chipping in as a receiver. George Kittle added 67 yards through the air, and Jauan Jennings and Christian McCaffrey combined for multiple chunk gains in the passing game. When the 49ers were balanced, Arizona’s defense struggled to slow them down.

On the other side of the ball, Carolina’s defense just allowed 223 passing yards and 125 rushing yards to the Falcons, including 104 yards and two scores from Bijan Robinson and 119 receiving yards to Drake London. That kind of profile will be tested by a 49ers offense that just watched McCaffrey average over 6 yards per carry and saw Purdy complete better than 70 percent of his throws in Arizona. The Panthers did generate enough offense to erase a 27–6 deficit in that game, but they also spent a lot of time chasing from behind.

Arizona showed that you can move the ball on San Francisco through the air, with Jacoby Brissett throwing for 452 yards on 47 completions, yet the 49ers still won comfortably by 19 points. Carolina’s pass-heavy approach with Young, McMillan, Legette and Dowdle should create opportunities, but the combination of San Francisco’s red-zone efficiency and Carolina’s issues containing both the run and deep shots suggests this could again tilt toward a higher-scoring contest that the 49ers control.

Carolina Panthers vs. San Francisco 49ers predictions

Total: Over 48.5 (-112) – Both teams are coming off games that sailed into the 50s and 60s, with Carolina giving up 27 and San Francisco allowing 22 while scoring 41, so another up-tempo, offense-driven script points toward the Over.

Moneyline: 49ers -345 – San Francisco just handled a 452-yard passing day from Arizona and still won by nearly three touchdowns, while Carolina needed overtime despite Young’s huge outing, making the 49ers the safer side to win outright.

Spread: 49ers -7 (-110) – With the Panthers’ defense surrendering 125 rushing yards and big receiving numbers last week and now facing McCaffrey and a 49ers attack that just won by 19 on the road, laying a full touchdown with San Francisco is reasonable.

Bet: 49ers ML (-345), 49ers -7 (-110), Over 48.5 (-112)

NFL Week 12 Best Bets

Check out our best NFL bets for Week 12:

• Buffalo Bills -6.5 vs. Tampa Bay Buccaneers (-110)
• Los Angeles Rams -3.5 vs. Seattle Seahawks (-105)
• San Francisco 49ers -7 vs. Carolina Panthers (-110)

Buffalo enters Week 12 after hanging 44 points on Tampa Bay behind Josh Allen’s 317-yard, three-touchdown performance. The Bills averaged 10.6 yards per attempt, hit multiple explosive plays through the air, and added three rushing touchdowns against a Buccaneers defense that surrendered 202 yards on the ground. Tampa Bay’s run defense issues are becoming a theme, and with Buffalo’s offense clicking in both phases, the Bills are positioned well to cover a manageable number at home.

Los Angeles draws a Seattle team that just mustered 19 points in a loss to the Rams last week while Sam Darnold threw four interceptions. Seattle rushed for only 135 yards on 35 carries and allowed Matthew Stafford to post a clean, efficient 130-yard, two-touchdown outing without a turnover. With the Rams running it for 119 yards and controlling the defensive line of scrimmage, this matchup favors L.A.’s balance and stability, especially if Seattle can’t clean up its turnover issues.

San Francisco remains one of the league’s most reliable favorites, and their 41–22 win in Arizona showcased why. Brock Purdy threw three touchdowns with no turnovers, Christian McCaffrey totaled 121 yards and two scores, and the 49ers averaged over six yards per play. Carolina, meanwhile, gave up 223 passing yards and 125 rushing yards to Atlanta and needed overtime despite Bryce Young’s 448-yard masterpiece. The Panthers’ defensive inconsistencies create a difficult matchup against a 49ers offense that rarely wastes possessions.

If you roll these three into a parlay at approximate prices of -110, -105, and -110, the combined odds land around +595. A $100 wager would return roughly $695 total ($595 profit).

Want more parlay bets?

Then check out our best NFL parlays of the week. For the NCAAF bettors, we also have some enticing College Football parlays for each and every week.