With four weeks left in the 2025-26 NFL regular season, all 32 NFL Teams will be in action. That means there are no teams on bye and no room for mistakes as Playoff hopes are on the line. And, there are a number of key divisional games that could impact postseason chances.

Week 15 starts off with a Thursday Night Football divisional showdown between the Atlanta Falcons and the Tampa Bay Buccaneers. Tampa Bay is in a head battle with the Panthers for the NFC South title.

Sunday’s schedule is headlined by multiple AFC showdowns with direct playoff impact: Bills–Patriots, Ravens–Bengals, Chargers–Chiefs, and Seahawks–Colts all carry major seeding consequences. Meanwhile, NFC contenders like the Eagles, Cowboys, Lions, Rams, Packers, and Vikings look to strengthen their positioning with only a few opportunities left to climb the standings.

Week 15 closes with an intriguing Monday Night Football matchup between the Miami Dolphins and Pittsburgh Steelers, with both teams fighting to stay alive in their respective playoff races. With just a few more weeks before the postseason begins, this slate is loaded with elimination-game energy, tight point spreads, and several potential statement performances.

Without any further delay, let’s take a look at the NFL Week 15 odds and make our early Week 15 picks. There’s no shame in getting your Week 15 NFL bets in early as there is some value on the boards.

NFL Week 15 Schedule

NFL Week 15 Odds

As we dive into the early Week 15 NFL odds, several notable betting lines stand out immediately at the best sports betting sites.

San Francisco is laying a massive number at home against Tennessee, while Dallas is once again a heavy favorite in a primetime spot. Green Bay and Denver meet in one of the tightest lines of the week, and Miami heads to Pittsburgh for a physical Monday Night Football matchup. Detroit–Los Angeles also projects as one of the highest-scoring games on the slate.

Totals are more modest than some earlier slates, but Lions–Rams and Dolphins–Steelers both sit in the mid-40s, while Panthers–Saints carries one of the lowest numbers of the week.

As always, monitor injuries, weather, and line movement as we get closer to kickoff, and don’t forget to check out our top player prop bets for more ways to attack this week’s card.

If you are in need of further betting assistance for Week 15, or any other week of the 2025-26 NFL season, then check out the industry’s best handicapping membership for thousands of NFL picks. And, the best part, you can take advantage of a free trial and see what’s under the hood.

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NFL Week 15 Predictions

Let’s take a look at the full slate of NFL Week 15 matchups and make our NFL picks for each game.

Atlanta Falcons vs. Tampa Bay Buccaneers Odds

The Tampa Bay Buccaneers come into this one off a narrow home loss where the offense never fully clicked but continued to show progress on the ground. Bucky Irving and Rachaad White both generated steady yardage, helping stabilize early downs even as the passing attack sputtered. Baker Mayfield struggled to find explosives, but Chris Godwin remained a steady chain-mover, and Tampa should have more room to operate against a softer Falcons secondary.

On defense, Tampa handled New Orleans’ passing game but was less sharp against the run, allowing quarterback keepers and misdirection to extend drives. That’s a key point here, as Atlanta leans heavily on Bijan Robinson and Tyler Allgeier to stay on schedule. If Tampa tightens inside, they’ll force Kirk Cousins into must-throw situations — something he struggled with last week.

The Atlanta Falcons enter off a decisive loss where the offense never found rhythm. Cousins threw two interceptions, protection broke down often, and the run game lacked its usual burst despite decent volume. With limited separation downfield and minimal explosive plays, the Falcons couldn’t threaten a Seattle defense that dictated tempo throughout.

Defensively, Atlanta was overwhelmed by Seattle’s balance. They allowed explosive gains to multiple receivers, gave up over 120 rushing yards, and rarely got off the field in defining moments. That’s a dangerous profile against a Bucs team that wants to run downhill, attack with play-action, and make the defense defend every blade of grass.

Atlanta Falcons vs. Tampa Bay Buccaneers Predictions

Spread: Buccaneers (–4.5): Tampa is the more balanced team right now, and Atlanta’s offense has shown little ability to respond when forced into passing scripts.

Total: (Under 44.5) Both offenses have leaned on the run and struggled to finish drives, pointing toward a slower, lower-variance game.

Moneyline: Buccaneers (-810) Tampa’s advantages at home and in the trenches make them the safer side.

Bet: Buccaneers –4.5, Under 44.5, Buccaneers ML (-230)

New York Jets vs. Jacksonville Jaguars Odds

The Jacksonville Jaguars come into this one playing their best football of the season, coming off a comfortable win where the offense controlled the game from start to finish. Trevor Lawrence moved the ball efficiently, throwing for over 240 yards with two touchdowns and no mistakes. Travis Etienne anchored the attack with volume and red-zone power, and Jacksonville’s receivers again produced chunk gains across all levels of the field.

Defensively, Jacksonville tightened significantly, allowing under 200 passing yards and generating pressure that disrupted Indianapolis’ timing. Their run defense held firm outside of a few short bursts, setting up long-yardage situations and limiting sustained drives. When the Jaguars play from ahead and dictate pace, their defensive structure becomes very difficult to break.

The New York Jets come into this matchup coming off a difficult offensive showing in which neither quarterback found consistent rhythm. Tyrod Taylor exited early, and Brady Cook took the majority of snaps but threw two interceptions while facing heavy pressure. New York managed only 65 rushing yards, and the passing game lacked downfield presence outside of a handful of throws to Mason Taylor and John Metchie. If Cook is forced to start again, the Jets’ passing ceiling narrows even further.

On defense, New York competed early but eventually wore down against Miami’s run-heavy attack. They allowed nearly 240 yards on the ground and struggled to contain perimeter runs, misdirection, and second-level bursts. That profile is problematic against a Jacksonville offense that thrives on balanced sequencing and can stress every defensive gap with Etienne and multiple vertical threats.

New York Jets vs. Jacksonville Jaguars Predictions

Spread: Jaguars (–12.5) Jacksonville has covered comfortably during this recent surge, and New York’s offensive limitations make it difficult to envision them keeping pace for four quarters.

Total: (Over 41.5) Jacksonville’s offense is rolling, and the Jets’ defense has been softening late in games. Even modest Jets scoring is enough to push this into the low-40s.

Moneyline: Jaguars (-800) With the more explosive offense, steadier quarterback play, and a defense trending upward, Jacksonville is the clear side at home.

Bet: Jaguars –12.5, Over 41.5, Jaguars ML (-800)

Cleveland Browns vs. Chicago Bears Odds

The Cleveland Browns come into Week 15 off a narrow, high-scoring loss where Shedeur Sanders played one of his better games of the season, throwing for over 350 yards and three touchdowns. Cleveland moved the ball well through the air but struggled to finish drives consistently, and protection issues resurfaced late as Tennessee generated pressure in key spots. The run game never established much rhythm, forcing Sanders into a pass-heavy script that left the offense one-dimensional.

Defensively, Cleveland allowed far too many explosive rushing plays, giving up over 180 yards on the ground and losing gap integrity against both inside and outside concepts. Missed tackles and slow pursuit angles put them behind schedule throughout the game, and that’s a dangerous sign heading into a matchup with Chicago’s two-headed backfield. In snowy conditions, this becomes a major stress point for a Browns defense that has been inconsistent versus downhill runners.

The Chicago Bears return home off a close loss to Green Bay but remain encouraged by their run-game output. D’Andre Swift and Kyle Monangai combined for over 110 yards, and Caleb Williams protected the ball better while keeping the offense on schedule. The passing attack lacked explosives, but Chicago sustained drives and consistently moved the ball into scoring territory before stalling. In heavy weather, this run-centric identity should fit the moment.

Defensively, the Bears played well enough to win, limiting big plays and forcing Green Bay into long possessions. They held the Packers’ rushing attack in check and forced Jordan Love to work methodically, something that matches up well against a Cleveland offense that leans on timing throws. In cold and snowy conditions, Chicago’s physicality and backfield depth become bigger edges, especially with the Browns struggling to stop the run.

Cleveland Browns vs. Chicago Bears Predictions

Spread: Bears (–7.5) Chicago’s ground game, combined with the weather and Cleveland’s run-defense issues, sets up a strong matchup advantage for the home side.

Total: (Under 39.5): With snow, low temperatures, run-heavy game plans, and two offenses prone to stalling in the red zone, this projects as one of the week’s lowest-variance scripts.

Moneyline: Bears (-410): The weather amplifies Chicago’s strengths and Cleveland’s weaknesses. The Bears’ style fits this environment far better.

Bet: Bears –7.5, Under 39.5, Bears ML (-410)

Buffalo Bills vs. New England Patriots Odds

The New England Patriots return from a bye after showing improvement in their passing game, with Drake Maye throwing for 282 yards and two touchdowns in his most efficient outing so far. Extra prep time should help New England script early success, but sustaining long drives remains a challenge for an offense that relies heavily on timing and short-area completions. Against Buffalo’s speed and disguised pressures, that margin tightens quickly.

New England has given up too many explosive plays, and Buffalo brings a multifaceted attack that stresses coverage at every level. Josh Allen played a clean, controlled game against Cincinnati, completing 22 of 28 passes and adding impact runs that extended drives. With the Bills finding steadier balance on the ground, they enter this matchup with more reliable ways to move the ball.

The Buffalo Bills’ defense handled its assignments well last week, forcing the Bengals into unfriendly down-and-distance spots and limiting early-down efficiency. If that carries into this week, New England will be forced into passing situations that expose its protection issues. The Patriots need this game to stay low-variance, but Buffalo’s offensive dynamism makes that difficult.

Conditions should be cold but not restrictive, which favors Buffalo’s ability to operate its full offense. New England may benefit early from preparation and home field, yet the Bills have clearer scoring pathways and stronger playmaking on both sides of the ball.

Buffalo Bills vs. New England Patriots Predictions

Spread: Bills +1.5: Buffalo’s offensive ceiling and matchup advantages make them the more trustworthy side, even as a short underdog.

Total: Under 50.5: New England still struggles to generate explosives, and their best path involves slowing tempo and limiting possessions.

Moneyline: Bills (-108) Buffalo’s efficiency and depth give them the edge in a game that should hinge on which offense can finish drives.

Bet: Bills +1.5, Under 50.5, Bills ML (-108)

Baltimore Ravens vs. Cincinnati Bengals Odds

The Baltimore Ravens return home after a draining loss to Pittsburgh in which the offense stalled repeatedly despite outgaining the Steelers. Lamar Jackson generated explosive plays but struggled with turnovers and off-script decisions, leaving too many points on the field. Baltimore’s protection issues also resurfaced, making them overly reliant on individual playmaking instead of sustained drives.

The Cincinnati Bengals are coming off their best offensive showing in weeks, with Joe Burrow carving up Buffalo and finishing with four touchdowns. Tee Higgins dominated intermediate routes while the run game provided just enough balance to keep the Bills honest. Defensively, the Bengals tightened coverage and forced Allen into several tight-window throws.

This matchup becomes more interesting given Baltimore’s recent defensive backslide. The Ravens were gashed repeatedly by Burrow last week, and Cincinnati has the weapons to stress their secondary again. If Baltimore doesn’t generate pressure quickly, Jackson may need to carry them in another high-possession shootout.

Given both teams’ volatility, this projects closer than the market implies. Cincinnati’s offensive rhythm—and their ability to finish drives—keeps them competitive throughout. If the Ravens cannot control pace with their run game, this becomes a coin flip decided by which quarterback avoids the costly turnover.

Baltimore Ravens vs. Cincinnati Bengals Predictions

Spread: Bengals +2.5 (–112) Burrow’s efficiency last week and Baltimore’s sudden coverage issues make Cincinnati live as an underdog.

Total: Under 52.5 (–110) Both teams can score, but long drives and inconsistent red-zone execution point slightly toward the Under.

Moneyline: Bengals (+114) Cincinnati’s revived passing game gives them real upset potential if Baltimore’s pressure doesn’t land early.

Bet: Bengals +2.5 (–112), Under 52.5 (–110), Bengals ML (+114)

Arizona Cardinals vs. Houston Texans Odds

The Arizona Cardinals‘ offense finally showed some rhythm last week with Jacoby Brissett throwing for 271 yards and keeping the passing game on schedule. Trey McBride and Michael Wilson combined for over 200 yards, giving the Cardinals reliable production at all three levels of the field. While the run game stalled again at just 51 total yards, the passing cohesion allowed Arizona to stay aggressive and avoid predictable play-calling. That competence alone makes this offense more competitive than it was earlier in the season.

The Houston Texans come into this matchup with C.J. Stroud continuing to operate at a high level. He threw for 203 yards on limited attempts and again connected with Nico Collins for multiple chunk gains, including a 53-yard strike that flipped the field. The Texans didn’t run the ball efficiently, averaging only 2.6 yards per carry, but their perimeter explosiveness makes up for those inconsistencies. As long as Stroud has time to work, Houston’s offense remains difficult to slow down for four quarters.

Defensively, Arizona held up early against Los Angeles before their issues resurfaced. The Rams piled up 249 rushing yards and hit several explosive plays, exposing Arizona’s tackling and gap integrity. The Cardinals did generate pressure in spots and handled quick-game concepts well, but they continue to struggle once opponents sustain drives. Against an offense with Houston’s vertical weapons, those breakdowns become much harder to survive.

Houston’s defense found its best form of the season last week, holding Kansas City to just 10 points and forcing multiple turnovers. The Texans controlled the line of scrimmage, allowing only 30 rushing yards to Kansas City’s backs, and their secondary held up even when Patrick Mahomes tried to push the ball downfield. The one vulnerability remains the occasional lapse against misdirection runs, but overall this is a defense trending upward at the right time. With Stroud protecting the ball, Houston’s defensive efficiency gives them a clear matchup edge.

Arizona Cardinals vs. Houston Texans Predictions

Spread: Cardinals +9.5 (–108) Arizona’s passing improvement makes this number a little inflated. If Brissett repeats his timing and efficiency, the Cardinals can hang around long enough to stay within the margin.

Total: Over 42.5 (–105) Both offenses create explosive plays, and both defenses give them up. A competitive game script pushes this toward the Over.

Moneyline: Texans (–575) Houston has the steadier quarterback play, the better trench presence, and the deeper perimeter threats. They are the deserved heavy favorite.

Bet: Cardinals +9.5 (–108), Over 42.5 (–105), Texans ML (–575)

Las Vegas Raiders vs. Philadelphia Eagles Odds

The Las Vegas Raiders continue to face offensive limitations, and those concerns only grow if Kenny Pickett is forced to start in place of Geno Smith. Pickett handled spot duty efficiently last week, but the Raiders’ offense still relies heavily on Brock Bowers and lacks the explosive balance needed to threaten a defense as physical as Philadelphia’s. Their run game remains inconsistent, and long-yardage downs have repeatedly derailed promising drives. Las Vegas simply struggles to generate the type of sustained production required to stay competitive against elite defenses.

The Philadelphia Eagles showed meaningful defensive improvement in Los Angeles, holding the Chargers to just 22 points in overtime despite constant pressure. Their run defense stiffened, their pass rush created disruption, and their secondary kept explosive plays in check. With Saquon Barkley anchoring the ground game and Jalen Hurts controlling tempo, the Eagles’ offense looks increasingly stable heading into December. That blend of power rushing and calculated passing puts them in a much stronger position than the Raiders’ undermanned unit.

The Eagles also match up well against the Raiders’ protection issues, as Philadelphia’s front consistently wins with power and speed on the edges. That poses major challenges for a Las Vegas line that allowed four sacks last week and routinely struggles against stunts and interior pressure. If Pickett starts, the Raiders will lean heavily on quick-game concepts, but that limits their ability to generate chunk plays and reduces their margin for error. Even with a clean game script, Las Vegas’ offensive ceiling remains low.

Given the disparity in offensive consistency, pass protection, and defensive reliability, Philadelphia holds clear advantages on both sides of the ball. Their ability to control the trenches on offense and defense should shape this matchup, while the Raiders’ quarterback uncertainty only widens the gap. Unless turnovers flip the field repeatedly, Las Vegas is unlikely to keep pace. Philadelphia’s advantages point strongly toward a comfortable win and a game that stays within a controlled scoring environment.

Las Vegas Raiders vs. Philadelphia Eagles Predictions

Spread: Eagles –11.5 (–110) Philadelphia’s defensive front and ground-game edge make this a difficult matchup for Las Vegas to remain competitive in.
Total: Under 38.5 (–112) Both offenses trend toward slower, methodical drives, and the Raiders lack explosive play potential.
Moneyline: Eagles (–850) Philadelphia controls more phases of the game and carries far greater reliability on both sides of the ball.

Bet: Eagles –11.5 (–110), Under 38.5 (–112), Eagles ML (–850)

Los Angeles Chargers vs. Kansas City Chiefs Odds

The Los Angeles Chargers enter this matchup showing renewed offensive life behind Kinami Vidal’s breakout and Justin Herbert’s sharp, efficient decision-making. Even while managing a thumb issue, Herbert delivered timely throws and avoided critical mistakes, and Los Angeles’ offensive line held up well enough to create rhythm and sustain drives. Their passing game has leaned on explosive plays at opportune moments, giving this offense a healthier pulse than it had midseason.

The Kansas City Chiefs limp into Week 15 following a crushing loss to Houston that likely ended their playoff hopes, marking an unfamiliar late-season spiral for the league’s recent dynasty. Patrick Mahomes again faced heavy pressure and was forced into hurried, low-efficiency throws, while the Chiefs’ receivers struggled to separate and dropped multiple on-target passes. The running game provided occasional bursts but lacked the consistency needed to stabilize the offense.

Defensively, the Chiefs continue to force pressure but are vulnerable to breakdowns in coverage. Rashee Rice and Xavier Worthy have flashed explosiveness, yet Kansas City’s passing rhythm remains dependent on Mahomes creating outside structure. Against a Chargers defense that has struggled but tightened in key moments, the Chiefs may find production difficult to sustain.

This game profiles as another tightly contested AFC West meeting, but the Chargers currently offer the steadier offensive structure. With Kansas City in a late-season freefall and lacking dependability on both sides of the ball, Los Angeles has a realistic path to keep this close throughout and potentially steal a win.

Los Angeles Chargers vs. Kansas City Chiefs Predictions

Spread: Chiefs –4.5 (–110) Kansas City’s defensive front should still create enough pressure to cover at home against an inconsistent Chargers secondary.

Total: Under 41.5 (–110) Neither offense has shown reliable drive-to-drive consistency, pushing this matchup toward a slower, lower-scoring result.

Moneyline: Chiefs (–218) Even with their struggles, Mahomes at home remains the safer side in a volatile matchup.

Bet: Chiefs –4.5 (–110), Under 41.5 (–110), Chiefs ML (–218)

Washington Commanders vs. New York Giants Odds

The Washington Commanders come into Week 15 licking its wounds after a 31–0 shutout in Minnesota where the offense never found a rhythm and Jayden Daniels re-injured his elbow. With Marcus Mariota likely under center, the Commanders should lean more into his mobility, boot action, and quick reads to get Terry McLaurin and Zach Ertz involved early. The run game at least showed some life with over 4 yards per carry, giving Washington a path to stay balanced if the offensive line holds up a little better.

The New York Giants are coming off a bye after getting handled 33–15 in New England, a game where Jaxson Dart was efficient but the offense stalled whenever it faced pressure. Devin Singletary gave them credible production on the ground, yet New York’s protection issues let the Patriots live in the backfield and kept the passing game stuck in short and intermediate windows. Extra rest should help the Giants clean up some of those problems and get a healthier look on both sides of the ball.

Defensively, Washington has been feast-or-famine, but the front still creates enough disruption to bother a young quarterback who likes to push the ball. The Commanders just surrendered 160+ rushing yards and multiple explosive gains, which is a concern against a Giants offense that quietly has a solid run script and a big-play receiver in Darius Slayton. If Washington tackles better on the edges and limits the deep shots, they can force New York into longer drives and more third-down decisions.

This shapes up as a volatile matchup between two inconsistent teams, which makes the points with the underdog attractive. Mariota’s legs add a different dimension to Washington’s offense, and the Commanders’ playmakers on the perimeter give them real comeback potential if they fall behind. With both defenses prone to breakdowns and the Giants laying more than a field goal after a bye, there is value backing Washington to cover and possibly win outright in a higher-scoring game than the market expects.

Washington Commanders vs. New York Giants Predictions

Spread: Commanders +2.5 (–110) Washington’s added rushing element with Mariota plus New York’s shaky pass protection give the Commanders enough edges to stay inside a field goal.

Total: Over 47.5 (–108) Both defenses allow explosive plays and struggle to finish drives with stops, pointing toward a game that can sneak into the low 50s.

Moneyline: Commanders (+114) If Washington avoids the disastrous turnovers that doomed them in Minnesota, their balance and quarterback mobility give them a live shot to steal this on the road.

Bet: Commanders +2.5 (–110), Over 47.5 (–108), Commanders ML (+114)

Indianapolis Colts vs. Seattle Seahawks Odds

The Indianapolis Colts limp into Week 15 in full survival mode after losing Daniel Jones to a torn Achilles and watching their QB room thin out again. Riley Leonard has been steady but limited, and with the Colts signing 44-year-old Philip Rivers as an emergency option, there’s a real possibility the veteran sees snaps despite not playing since 2020. The offense still runs primarily through Jonathan Taylor, but his production has fluctuated against stronger fronts, putting pressure on a passing game that lacks explosive upside.

The Seattle Seahwaks, meanwhile come in rolling after another dominant defensive outing that featured multiple takeaways and consistent pressure from the front seven. Sam Darnold continues to guide the offense with efficient decision-making, while the rushing duo of Kenneth Walker and Zach Charbonnet gives the Seahawks reliable early-down juice. Their wideouts remain matchup problems, especially with Jaxon Smith-Njigba emerging as a high-volume, chain-moving weapon.

This matchup heavily favors Seattle in the trenches. The Colts’ offensive line has struggled to generate clean pockets, and without Jones’ mobility, Leonard or Rivers would be facing a relentless pass rush that feasted on Atlanta last week. Indianapolis has shown heart by staying in games late, but the absence of explosive plays continues to cap their scoring ceiling.

Even with playoff hopes on the line, Indianapolis faces an uphill battle. Seattle’s consistency on both sides of the ball and their ability to control tempo forces the Colts into long, methodical drives—something they’ve rarely executed cleanly. Unless Taylor breaks multiple chunk plays or the Colts’ defense forces turnovers, Seattle’s overall stability gives them a significant edge.

Indianapolis Colts vs. Seattle Seahawks Predictions

Spread: Seahawks –14 (–108) — Seattle’s defensive strength and matchup advantages support the big number.
Total: Under 42.5 (–112) — Indianapolis’ offensive limitations and Seattle’s control-heavy style lean under.
Moneyline: Seahawks (–1000) — A heavy favorite with a clear talent and consistency advantage.

Bet: Seahawks –14 (–108), Under 42.5 (–112), Seahawks ML (–1000)

Tennessee Titans vs. San Francisco 49ers Odds

The scuffling Tennessee Titans come into Week 15 with a rare spark of momentum after stealing a last-second win in Cleveland. Their offense continues to lean heavily on Tony Pollard’s burst and T.J. Spears’ versatility, and Cam Ward’s legs remain their most reliable source of explosives. Ward still struggles with accuracy and sacks, but the Titans have at least shown signs of stabilizing offensively. Defensively, Tennessee continues to give up chunk plays, especially through the air, and remains vulnerable in late-down situations.

The San Francisco 49ers return from the bye having dominated Cleveland two weeks ago behind Brock Purdy’s efficiency and Christian McCaffrey’s workload. Their offensive identity remains sharp: quick-game efficiency, early-down success, and timely shots to Brandon Aiyuk or George Kittle. The run defense continues to smother opponents, and their pass rush forces quarterbacks into hurried, mistake-heavy scripts. When the 49ers win early downs, opponents rarely find footing.

The matchup poses significant structural issues for Tennessee. Their offensive line still struggles in protection, and Ward’s improvisation is unlikely to consistently escape San Francisco’s disciplined pressure. On the other side, the Titans’ secondary has been one of the league’s most generous units, and Purdy has feasted on secondaries that fail to disrupt rhythm throws. Even if Tennessee leans on the run, game script is likely to shift quickly in the 49ers’ favor.

San Francisco should control tempo, early downs, and the overall possession profile. Tennessee may generate the occasional explosive run, but sustaining drives against this defense is a steep ask. With the 49ers rested and healthy after the bye, the talent gap widens further.

Tennessee Titans vs. San Francisco 49ers Predictions

Spread: 49ers –12.5 (–115) San Francisco’s edges in protection, efficiency, and explosive prevention make this a lopsided matchup.

Total: Under 44.5 (–110) Tennessee’s offense lacks sustained scoring reliability, and the 49ers typically drain clock when leading.

Moneyline: 49ers (–1000) San Francisco holds advantages in every major phase and should control the game wire to wire.

Bet: 49ers –12.5 (–115), Under 44.5 (–110), 49ers ML (–1000)

Green Bay Packers vs. Denver Broncos Odds

The Green Bay Packers roll into this matchup looking steadier after Jordan Love delivered three touchdown passes in a win over Chicago. Their offense leaned on the run game to stay balanced, and Christian Watson’s return has helped unlock more of their vertical passing structure. While Green Bay still battles inconsistency up front, their play-action game continues to create chunk opportunities when Love is kept clean.

The Denver Broncos ride into Week 15 with one of the league’s best records and a defense that has tightened considerably over the past month. Bo Nix remains efficient and turnover-averse, distributing the ball in rhythm while the Broncos work through a committee backfield. Even with moderate yardage totals, Denver’s offense has remained effective situationally, especially in the red zone. Their recent win over Las Vegas highlighted how well they can control the middle of the field when their receivers create separation early.

The Broncos’ defense has also grown more consistent, allowing fewer explosive plays as their secondary settles into a healthier rotation. Their front still struggles to generate a high sack rate, but they’ve forced opponents into longer drives and limited the costly busts that defined their early-season issues. Against a Packers team that leans on downfield timing routes, Denver’s discipline in space becomes a key factor.

Green Bay’s advantages lie in their vertical threats and their ability to create misdirection touches for their playmakers. Denver’s strength is in their balanced approach and their ability to stay in manageable down-and-distance situations. This matchup projects tight, but Green Bay’s ability to finish drives gives them a narrow edge.

Green Bay Packers vs. Denver Broncos Predictions

Spread: Packers –2.5 (–110) Green Bay’s offensive efficiency and red-zone reliability give them a slight edge in a close matchup.

Total: Under 43.5 (–115) Denver slows games down, and Green Bay’s defense is trending upward, making the Under the cleaner angle.

Moneyline: Packers (–135) Green Bay’s passing structure matches up well with Denver’s soft spots, giving the Packers the straight-up advantage.

Bet: Packers –2.5 (–110), Under 43.5 (–115), Packers ML (–135)

Detroit Lions vs. Los Angeles Rams Odds

The Detroit Lions come into this matchup looking for a rebound after an uneven defensive showing against Dallas, but the offense remains capable of creating explosive plays. Jared Goff gets another crack at his former team, and Detroit’s vertical passing threats continue to generate chunk yardage when protected. The Lions’ run game has become more matchup-specific, but Jahmyr Gibbs and David Montgomery still offer balance when game script cooperates.

The Los Angeles Rams return home after detonating Arizona with one of their cleanest offensive games of the season. Matthew Stafford threw three touchdowns, the ground game erupted for 249 yards, and Blake Corum and Kyren Williams looked unstoppable behind a line that consistently generated movement. The Rams also showcased perimeter dominance with Puka Nacua and Colby Parkinson creating repeated separation.

This matchup brings the unique element of a double revenge game — Stafford against Detroit and Goff against Los Angeles — and both quarterbacks are supported by high-end offensive infrastructure. Los Angeles holds the defensive edge, especially with better red-zone reliability, but Detroit’s aggressiveness keeps them within striking distance in shootout scripts. If the Lions can avoid early negative plays, their explosive pass game can match the Rams score for score.

Given how both offenses are trending, this projects as one of the highest-scoring games of the entire week. Los Angeles has the deeper set of answers across multiple phases, but Detroit’s variance profile gives them backdoor potential. The Rams’ run game may prove to be the stabilizing factor that controls tempo late, especially if their front slows Detroit’s early-down efficiency.

Detroit Lions vs. Los Angeles Rams Predictions

Spread: Lions +5.5 (–108): Detroit’s explosive passing profile keeps them competitive enough to stay within this number.

Total: Over 55.5 (–105): Both offenses can generate explosives through the air and on the ground, pointing this toward a shootout.

Moneyline: Rams (–245): Los Angeles holds the stronger defensive consistency and better trench play, giving them the edge outright.

Bet: Lions +5.5 (–108), Over 55.5 (–105), Rams ML (–245)

Carolina Panthers vs. New Orleans Saints Odds

The Carolina Panthers return from the bye week with a more balanced identity taking shape around Bryce Young. Before the break, the Panthers put together their most complete outing of the season, scoring 31 points and generating 164 rushing yards on the Rams’ defense. The improved structure in their run game stabilized early downs and gave Young cleaner pockets, helping him complete 15 of 20 attempts with three touchdown throws. If that balance carries over, the offense should remain more functional against a Saints defense that has been vulnerable to sustained rushing volume.

The New Orleans Saints come in with ongoing inconsistency under Tyler Shough, who threw for just 144 yards last week and remains prone to drive-stalling sacks. The Saints did lean on Devin Neal effectively, and the run game provided 139 yards and three touchdowns, but their offense continues to lack rhythm through the air. Explosive pass plays have been limited, and when opponents force Shough into must-throw situations, the offense tends to flatten out. That issue becomes more pronounced against defenses disciplined in space.

Carolina’s defense has trended upward, especially in coverage. They limited Matthew Stafford to 243 passing yards last time out and held the Rams to just 58 combined rushing yards outside of Blake Corum’s long run. Their young secondary has tightened up in man coverage, and the bye week offers additional opportunity to refine communication on the back end. If they maintain their improved tackling, they should be positioned to keep the Saints’ perimeter threats from taking over.

This matchup projects as a lower-scoring game driven by the run game on both sides. New Orleans has struggled to sustain drives without the benefit of explosive plays, and Carolina’s retooled offense aims to control tempo behind Chuba Hubbard and Rico Dowdle. With the Panthers entering healthier and more structured after the bye, they appear better equipped to stay within the number and contend into the fourth quarter.

Carolina Panthers vs. New Orleans Saints Predictions

Spread: Panthers +2.5 (–115)
Carolina’s improved run game and offensive balance give them enough stability to stay inside this number.

Total: Under 40.5 (–110)
Both offenses lean on the run and lack consistent explosive threats, keeping this matchup trending toward the Under.

Moneyline: Panthers (+120)
Carolina enters healthier and playing its best football of the season, making them a live underdog.

Bet: Panthers +2.5 (–115), Under 40.5 (–110), Panthers ML (+120)

Minnesota Vikings vs. Dallas Cowboys Odds

The Minnesota Vikings are off a dominant defensive outing against Washington, but their offense continues to stall with JJ McCarthy’s inconsistency. The passing game generated only 151 yards last week, and the ground attack hasn’t been able to create enough explosive plays to ease the pressure on the rookie quarterback. Minnesota’s protection also remains an issue, allowing consistent backfield penetration that disrupts rhythm before plays can develop.

Defensively, the Vikings showed real growth last week by forcing multiple turnovers and keeping Washington scoreless. Their run fits were sharp, and they closed on short-area throws effectively. But this week presents a much steeper challenge, as Dallas’ passing game is far more efficient and capable of stretching Minnesota’s secondary vertically and horizontally.

The Dallas Cowboys enter this matchup rolling on offense despite last week’s loss, with Dak Prescott throwing for 376 yards and continuing to play at a high level overall. CeeDee Lamb is one of the league’s most difficult matchups, and Dallas’ ability to scheme him open stresses opposing secondaries. The Cowboys also showed signs of an improving run game with Javonte Williams providing steady production between the tackles.

The Cowboys’ front seven presents a major problem for Minnesota’s offensive line, especially on passing downs. Dallas’ speed off the edge has consistently overwhelmed weaker protection units, and that’s exactly where Minnesota has struggled. Given Dallas’ ability to dictate game flow with pressure and explosive passing, the Vikings face a steep uphill battle on the road.

Minnesota Vikings vs. Dallas Cowboys Predictions

Spread: Cowboys –5.5 (–110): Dallas’ passing efficiency and defensive pressure give them a clear matchup edge.

Total: Over 47.5 (–112): Dallas can push the pace, and Minnesota’s defense may eventually wear down.

Moneyline: Cowboys (–270): Dallas is the stronger, more stable team with the more trustworthy offense.

Bet: Cowboys –5.5 (–110), Over 47.5 (–112), Cowboys ML (–270)

Miami Dolphins vs. Pittsburgh Steelers Odds

The Miami Dolphins continue to lean on De’Von Achane’s explosive rushing ability and a more controlled passing game from Tua Tagovailoa. Their efficiency dipped earlier in the year, but the offense has recently become steadier and less turnover-prone. Miami still struggles with consistency drive-to-drive, but their ground game creates the explosive plays they need.

The Pittsburgh Steelers roll in after another gritty defensive effort, holding Baltimore in check and generating multiple passing-game disruptions. Aaron Rodgers remains limited behind a shaky line, and the Steelers’ offense relies heavily on hitting isolated matchups rather than sustaining long drives. Their defensive front, however, continues to lift the team by creating pressure and forcing stalled possessions.

This matchup comes down to Miami’s balance versus Pittsburgh’s ability to win at the line of scrimmage. Achane gives the Dolphins a mismatch wherever he lines up, and Miami’s run game could be the deciding factor if conditions tighten scoring. Pittsburgh’s defense will keep them in it, but their offensive inconsistency remains a major concern.

Miami’s ability to generate explosive runs gives them a real shot on the road, even against a disciplined Steelers defense.

Miami Dolphins vs. Pittsburgh Steelers Predictions

Spread: Dolphins +3 (+100): Miami’s run game gives them enough stability to stay inside the number.

Total: Under 42.5 (–110): Pittsburgh’s offense has trouble sustaining drives, pushing this toward a lower-scoring script.

Moneyline: Dolphins (+145): Miami’s explosive play edge makes them a live underdog.

Bet: Dolphins +3 (+100), Under 42.5 (–110), Dolphins ML (+145)

NFL Week 15 Best Bets

Here are our favorite NFL bets for Week 15:

• Green Bay Packers –2.5 vs. Denver Broncos (–110)
• Detroit Lions +5.5 at Los Angeles Rams (–108)
• Miami Dolphins +3 at Pittsburgh Steelers (+100)

Green Bay draws a Denver team leaning heavily on efficiency from Bo Nix and the run game, but the matchup shifts in the Packers’ favor with their improved vertical passing rhythm and better red-zone consistency. With Watson back in the lineup and Josh Jacobs stabilizing the ground game, Green Bay should control enough possessions to cover the small number at home.

Detroit enters this revenge matchup with Matthew Stafford needing to keep pace, and the Lions’ offensive explosiveness gives them a strong chance to stay inside this spread. Jared Goff has been efficient, Gibbs and Montgomery remain dangerous in space, and Detroit’s protection—while inconsistent—matches up better here than it did against recent pass-rush heavy opponents.

Miami’s offense continues to lean on De’Von Achane’s explosiveness, and the Dolphins bring far more balance than Pittsburgh right now. Aaron Rodgers has steadied the Steelers, but their offense still struggles to generate consistent explosive plays. If Miami protects Tua and sustains early-down efficiency, they have the playmakers to cover and potentially win outright on Monday night.

If you roll these three favorites into an NFL parlay, the combined odds fall in the approximate range of +500 to +550. A $100 wager would return roughly $600–$650 total. As always, shop for the best numbers across your sportsbook accounts and consider pairing these sides with your favorite College Football parlays for added value.