2025 NFL Week 16 Odds and Predictions For Each Game

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Week 16 has a big-fight feel to it as we see a number of matchups that could determine division winners and Playoff contenders.

The first game of the week is a Thursday Night Football matchup between the Los Angeles Rams and Seattle Seahawks. This NFC West battle could decide the outcome of the divisional race with just a few games left in the season.

Football fans won’t have to wait until Sunday, Dec. 21, for the next games as Week 16 boasts of two exciting NFC showdowns on Saturday, Dec. 20, with the Eagles playing at the Commanders and we’ll also see another chapter in the NFL’s oldest rivalry – the Bears vs. Packers.

Sunday’s slate features two key AFC matchups as the Patriots play at the Ravens and the Dolphins host the Bengals.

Sprinkled on top of this mound of gridiron goodness, are two cross-conference matchups as the Chargers visit the Cowboys and the Lions host the Steelers. By time Sunday is all said and done, we could see a few teams eliminated from Playoff contention.

With that said, let’s take a look at the NFL Week 16 odds and make our early Week 16 picks. There’s no shame in placing your Week 16 NFL bets months ahead of time, as we do see some value on the boards.

NFL Week 16 Schedule

DateTime (ET)Road TeamHome Team
Thursday, Dec. 188:15pmLos Angeles RamsSeattle Seahawks
Saturday, Dec. 20TBDPhiladelphia EaglesWashington Commanders
Saturday, Dec. 20TBDGreen Bay PackersChicago Bears
Sunday, Dec. 211pmLos Angeles ChargersDallas Cowboys
Sunday, Dec. 211pmKansas City ChiefsTennessee Titans
Sunday, Dec. 211pmTampa Bay BuccaneersCarolina Panthers
Sunday, Dec. 211pmBuffalo BillsCleveland Browns
Sunday, Dec. 211pmNew England PatriotsBaltimore Ravens
Sunday, Dec. 211pmNew York JetsNew Orleans Saints
Sunday, Dec. 211pmMinnesota VikingsNew York Giants
Sunday, Dec. 214:05pmAtlanta FalconsArizona Cardinals
Sunday, Dec. 214:05pmJacksonville JaguarsDenver Broncos
Sunday, Dec. 214:25pmLas Vegas RaidersHouston Texans
Sunday, Dec. 214:25pmPittsburgh SteelersDetroit Lions
Sunday, Dec. 218:20pmCincinnati BengalsMiami Dolphins
Monday, Dec. 228:15pmSan Francisco 49ersIndianapolis Colts

NFL Week 16 Odds

The NFL odds for Week 16 features three NFL teams sitting as large favorites of at least a touchdown or more at the best sports betting sites.

The Chiefs are favored by a touchdown at Tennessee, while the Bills and Ravens are both favored by 8.5 points in their respective matchups. Buffalo is at Cleveland and Baltimore hosts the Patriots. The Ravens have a slightly higher moneyline than the Bills at -380 compared to -375 odds.

The largest Total for the week is the Bengals vs. Dolphins at 48.5 points. This game could be a track meet with plenty of player prop bets worth considering.

And, as usual, if you need any additional betting assistance for Week 16, or any other week of the 2025-26 NFL season, then check out the industry’s best handicapping membership for thousands of NFL picks via elite handicappers. Take advantage of the free trial and take this membership for a test ride.

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NFL Week 16 Predictions

Let’s take a look at the full slate of NFL Week 16 matchups and make our NFL picks for each game.

Los Angeles Rams vs. Seattle Seahawks Odds

TeamMoneylineSpreadTotal
Los Angeles Rams-120-1.5 (-110)Over 44.5 (-110)
Seattle Seahawks+100+1.5 (-110)Under 44.5 (-110)

Coming into the season, these two divisional foes have played against each other 55 times and it’s the Seattle Seahawks with a narrow lead at 28-27. However, the Los Angeles Rams have won three of the last four meetings including two in a row at Seattle.

Los Angeles Rams vs. Seattle Seahawks Predictions

This is the week that the Seahawks are eliminated from the NFC West race and most likely the Wild Card race as well. I think Seattle will finish with a winning record, but they won’t be much of a match for the Rams in the division.

The Rams are poised to make a deep run in the Playoffs depending on who their first postseason matchup is. Yet, without getting too far ahead of ourselves, Los Angeles should be one of the Top 4 teams in the NFC and be a respectable Super Bowl contender.

I expect the Rams to go into Seattle and play a strong game on both sides of the ball. Eventually, their defense will put the offense in favorable scenarios late in the game, which will seal the victory for LA.

Bet: Los Angeles Rams (-120), Rams -1.5 (-110)

Philadelphia Eagles vs. Washington Commanders Odds

TeamMoneylineSpreadTotal
Philadelphia Eagles-122-1.5 (-110)Over 45.5 (-110)
Washington Commanders+102+1.5 (-110)Under 45.5 (-110)

Entering the season, these rivals have played against each other 181 times. The Washington Commanders have a slight lead with a 90-86-5 record. However, it’s the Philadelphia Eagles that have won gone 13-4 in the last 17 head-to-head meetings.

Let’s not forget that the Eagles beat the Commanders in the NFC Championship game last season. Yet, it was Washington that won at home over Philly in dramatic fashion last year.

Philadelphia Eagles vs. Washington Commanders Predictions

The NFC East is going to be a battle between the Eagles and Commanders. This Week 16 matchup could be the tie breaker to decide which team wins the division at the end of the year.

Both teams are more than capable of winning this matchup, which is why the odds are so close. It will be interesting to see if Washington can take that next step towards representing the NFC in the Super Bowl or if the Eagles will stay on top of the conference.

For this matchup, I like Washington to win a big game at home and really punctuate Jayden Daniels MVP-caliber season. I see the Commanders holding on for the victory and positioning themselves as one of the best in the conference.

Bet: Washington Commanders (+102), Commanders +1.5 (-110)

Green Bay Packers vs. Chicago Bears Odds

TeamMoneylineSpreadTotal
Green Bay Packers-120-1.5 (-110)Over 45.5 (-110)
Chicago Bears+100+1.5 (-110)Under 45.5 (-110)

Entering the 2025-26 NFL season, these historic rivals have played against each other 210 times. The Green Bay Packers hold a 108-96-6 record in this series. Additionally, the Packers had won 11 in a row until the Chicago Bears took a meaningless victory in the final week of the 2024-25 season.

Green Bay Packers vs. Chicago Bears Predictions

You have to like how the schedule makers booked Week 16. They start the week off with three divisional matchups that could all have massive impact on the NFC Playoff picture. This NFC North battle will be just as big as the Rams vs. Seahawks and Eagles vs. Commanders.

I do expect the Bears to be a Wild Card contender as they make a big improvement over last year’s debacle. I see Chicago playing solid football on both sides of the ball. However, they will be led by their offense in this matchup.

Look for Caleb Williams to have a big game against Chicago’s bitter rival. In this week, I see Williams outplaying Green Bay’s Jordan Love and for the Bears to get a hard-fought victory.

Bet: Chicago Bears (+100), Bears +1.5 (-110)

Los Angeles Chargers vs. Dallas Cowboys Odds

TeamMoneylineSpreadTotal
Los Angeles Chargers-122-1.5 (-110)Over 46.5 (-110)
Dallas Cowboys+102+1.5 (-110)Under 46.5 (-110)

The Dallas Cowboys lead this series with an 8-5 record. They’ve also won two in a row over the Los Angeles Chargers. Their last meeting came in 2023, and Dallas won 20-17. In fact, that was the same exact score in their 2021 game as well. However, the Chargers have won three in a row at Dallas.

Los Angeles Chargers vs. Dallas Cowboys Predictions

This Week 16 matchup is going to be crucial for both teams as they fight for Wild Card berths. For me, I like the Chargers in this game.

I see LA playing a physical style of football that the Cowboys can’t match. Unless Dallas unveils a Top 15 running game, they’re going to be a one-dimensional offense that teams figure out by late-December.

The Chargers can run the ball with two talented running backs, and throw the ball which was evident by Justin Herbert’s 2024 season.

I believe the Chargers’ offensive line will be one of their biggest strengths all season long. They will protect Herbert from this Cowboys’ pass rush and allow the QB to pick apart a suspect secondary.

The Chargers keep their Playoff hopes alive with a big road win, while Dallas fans start mumbling about Jerry Jones’ needing to sell the team for what feels like the 20th straight December.

Bet: Los Angeles Chargers (-122), Chargers -1.5 (-110)

Kansas City Chiefs vs. Tennessee Titans Odds

TeamMoneylineSpreadTotal
Kansas City Chiefs-298-7 (-110)Over 44.5 (-110)
Tennessee Titans+240+7 (-110)Under 44.5 (-110)

Dating back to the Houston Oilers era, these two teams have played against each other 56 times. The Kansas City Chiefs hold the lead in this series with a 31-25 record. However, the Tennessee Titans have won five of the last seven meetings.

The last head-to-head matchup was in 2022, and the Chiefs won in OT by the score of 20-17. In 2021, the Titans won at home over the Chiefs by the score of 27-3.

Kansas City Chiefs vs. Tennessee Titans Predictions

The Chiefs will not only win this game, but I think this will be the week that they officially win the AFC West once again. It will be a tight race for most of the season, but the Chiefs are still the best team in the division. I do expect the Broncos to give KC its toughest test within the West.

As for this matchup, there’s no reason to think that the Titans can pull off the upset. They’re outgunned on both sides of the ball and in the coaching department as well. Chris Jones will be a nightmare for Cam Ward.

On the flip side, Patrick Mahomes will pick apart the Tennessee defense and KC should win by double digits on the road.

Bet: Kansas City Chiefs (-298), Chiefs -7 (-110)

Tampa Bay Buccaneers vs. Carolina Panthers Odds

TeamMoneylineSpreadTotal
Tampa Bay BuccaneersNANANA
Carolina PanthersNANANA

With 49 games played between these two divisional foes coming into the season, it’s the Carolina Panthers that hold the slight lead in this series with a 25-24 record. However, the Tampa Bay Buccaneers have won 11 of the last 13 meetings including vie in a row. The Bucs have also won four of their last five trips to Carolina.

Tampa Bay Buccaneers vs. Carolina Panthers Predictions

This NFC South matchup should be entertaining for fans of both teams. It could also be a sneaky game for fantasy football Playoffs.

With that said, the Buccaneers appear poised to win the division once again, unless the Falcons can take that top spot. While I do see the Panthers being a much better team and flirting with a .500 record, they’re still a season or two away from being a real contender in the division.

I expect the Bucs to shut down Carolina’s respectable running game, while Tampa’s offense pours on the points like gasoline on a fire. Tampa wins this game by at least a touchdown.

Bet: Tampa Bay Buccaneers (NA)

Buffalo Bills vs. Cleveland Browns Odds

TeamMoneylineSpreadTotal
Buffalo Bills-375-8.5 (-110)Over 43.5 (-110)
Cleveland Browns+295+8.5 (-110)Under 43.5 (-110)

The Cleveland Browns hold the lead in this rivalry with a 13-10 record. However, the Buffalo Bills have won five of the last seven meetings. Their last game came in 2022, where the Bills won 31-23 at home. The last game in Cleveland came in 2019, where the Browns won 19-16. Cleveland has won two in a row at home over Buffalo.

Buffalo Bills vs. Cleveland Browns Predictions

There was a time when this Lake Erie battle was one of the most important in the AFC. Yes, we’re looking at you Don Bebee! Growing up in Buffalo, I remember some of these matchups and how notable they were for both franchises every time they met.

Unfortunately, that’s not the case now. In fact, we’re a long way from this being a true rivalry like from years past.

The Bills will ride into Cleveland, torch the Browns on both sides of the ball, and leave town with another victory on the year. The Browns will feel helpless and hapless, which could lead to another organizational overhaul.

Bet: Buffalo Bills (-375), Bills -8.5 (-110)

New England Patriots vs. Baltimore Ravens Odds

TeamMoneylineSpreadTotal
New England Patriots+300+8.5 (-110)Over 46.5 (-110)
Baltimore Ravens-380-8.5 (-110)Under 46.5 (-110)

With 16 meetings between these teams, the New England Patriots hold a commanding lead at 11-5. Yet The Baltimore Ravens have won two of the last three matchups. Their last contest came in 2022. Baltimore has won 2 of their last three home games versus the Patriots.

New England Patriots vs. Baltimore Ravens Predictions

The Patriots will finish the season as the second-best team in the AFC East, behind the Bills. However, I do believe that the Ravens will win the AFC North and they could clinch the division with a Week 16 win over the Patriots.

New England is on the rise, but they’re traveling to a tough environment and playing against a true Super Bowl contender. Additionally, the Ravens have the physical style of offense that could steamroll this Patriots defense.

On the flip side, the revamped Baltimore secondary will make things hard for Drake Maye and this passing offense. Look for Baltimore to pull away in the second half on the legs of both Henry and Jackson.

Bet: Baltimore Ravens (-380)

New York Jets vs. New Orleans Saints Odds

TeamMoneylineSpreadTotal
New York Jets+100+1.5 (-110)Over 41.5 (-110)
New Orleans Saints-120-1.5 (-110)Under 41.5 (-110)

The New York Jets and New Orleans Saints have played 14 times against each other, and it’s the Saints that hold the 8-6 lead. New Orleans has also won four of the last five meetings and seven of the last nine matchups. Their last game was played in 2021, and the Saints won by the score of 30 to 9.

New York Jets vs. New Orleans Saints Predictions

Here we have the toilet bowl of Week 16. In fact, I will be shocked if these two teams have a combined win total of seven games by this matchup. I see both franchises in need of a savior at QB and both fighting for the top spot in next year’s draft.

With that said, the Jets defense should still be better than New Orleans’ defense. And I do think Fields can outperform anyone that the Saints throw out at QB.

If there’s any karma in the football world, then this game should end in a tie. However, I will take the Jets and the points in this ugly football game.

Bet: New York Jets (+100), Jets +1.5 (-110)

Minnesota Vikings vs. New York Giants Odds

TeamMoneylineSpreadTotal
Minnesota Vikings-130-2.5 (-110)Over 42.5 (-110)
New York Giants+110+2.5 (-110)Under 42.5 (-110)

The Minnesota Vikings and New York Giants have played against each other 32 times. The Vikings hold the lead with a series record of 19 to 13. Additionally, the Vikings have won five of the last six meetings.

These two teams played against each other last year, and Minnesota won 28 to 6 at New York. The Vikings have won the last two games at the Giants by the combined score of 56 to 16.

Minnesota Vikings vs. New York Giants Predictions

I’m not a believer in either team this year. In fact, I think both franchises will miss out on making the playoffs. I don’t see McCarthy duplicating what Sam Darnold did for Minnesota next year. And, I don’t see Russel Wilson saving this Giants’ team from another miserable season.

However, I do think that Minnesota is still better than New York especially on offense. Look for the Vikings to hold on for an ugly win and stay mathematically alive for the Playoffs.

The Giants will turn their attention towards New Year’s resolutions and holiday plans as they’re going nowhere but home in January.

Bet: Minnesota Vikings (-130), Vikings -2.5 (-110)

Atlanta Falcons vs. Arizona Cardinals Odds

TeamMoneylineSpreadTotal
Atlanta Falcons+150+3.5 (-110)Over 46.5 (-110)
Arizona Cardinals-180-3.5 (-110)Under 46.5 (-110)

With 34 games played between these bird teams, it’s the Arizona Cardinals with the slight lead at an 18-16 record. However, the Atlanta Falcons have won six of the last nine meetings. Yet, Arizona has won their last five home games in a row over Atlanta.

Atlanta Falcons vs. Arizona Cardinals Predictions

I think that both of these NFC teams should be alive in the Wild Card race by time Week 16 rolls around. I like how both franchises have put together some young pieces on offense as they both feature two young, dynamic QBs.

For Atlanta, Penix’s growth will be the biggest storyline all season long. He’s showed flashes of that already and this offense has all the potential to be Top 10 in the league.

For Arizona, it will be about the defense keeping this team in ball games while the offense continues to find success with Murray at the helm.

I think these teams are much closer in talent than what the odds indicate. I like Arizona with the home field advantage in this one. But I do see the Falcons covering the spread. This has the makings of a thrilling, last-minute win for the Cardinals. 

Bet: Arizona Cardinals (-180), Falcons +3.5 (-110)

Jacksonville Jaguars vs. Denver Broncos Odds

TeamMoneylineSpreadTotal
Jacksonville Jaguars+185+5.5 (-110)Over 45.5 (-110)
Denver Broncos-225-5.5 (-110)Under 45.5 (-110)

The Denver Broncos and Jacksonville Jaguars have played 15 times against each other and it’s the Broncos with a slight 8-7 lead. Additionally, the Broncos have won four of the last five meetings. However, these two teams are 4-4 in games played at Denver. In fact, the Jags have won three of the last four meetings there.

Jacksonville Jaguars vs. Denver Broncos Predictions

I’m actually surprised that the spread isn’t higher for this matchup. The Denver Broncos are the superior team on both sides of the ball. I expect them to shut down this Jaguars offense as they smother the talented receivers and harass Trevor Lawrence all game long.

On the flip side, the Denver offensive line will be the unsung heroes in this matchup as they open up running lanes and protect QB Bo Nix. Look for this Denver offense to put up points early and often as they beat up on an inferior Jacksonville defense.

Denver will win this matchup by double digits.

Bet: Denver Broncos (-225), Broncos -5.5 (-110)

Las Vegas Raiders vs. Houston Texans Odds

TeamMoneylineSpreadTotal
Las Vegas Raiders+164+4.5 (-110)Over 43.5 (-110)
Houston Texans-198-4.5 (-110)Under 43.5 (-110)

The Houston Texans and Las Vegas Raiders have played against each other 13 times and it’s the Texans with an 8-5 series lead. However, the Raiders won their last meeting which came in 2022. Houston is 4-2 in home games versus the Raiders and have won two in a row.

Las Vegas Raiders vs. Houston Texans Predictions

The Raiders will be thinking about next year as they enter this Week 16 matchup against the Texans. Las Vegas is at least a season or two away from being a winning football team

On the other side of the field, I expect the Houston Texans to run away with the AFC South division and start focusing on how they can get a higher seed in the AFC.

These are the type of games where teams can have a letdown as they look ahead. However, I see Houston using this game as an opportunity to make a statement to the rest of the conference that they are a real contender.

Houston’s defense mauls this Las Vegas offense. The Houston offense won’t have to do much as I wouldn’t be surprised if their defense scores more points than the Raiders’ offense does. Take the Texans to win by double digits. This spread is way too low for the difference in caliber of teams.

Bet: Houston Texans (-198), Texans -4.5 (-110)

Pittsburgh Steelers vs. Detroit Lions Odds

TeamMoneylineSpreadTotal
Pittsburgh Steelers+195+6 (-110)Over 45.5 (-110)
Detroit Lions-238-6 (-110)Under 45.5 (-110)

Surprisingly, these two non-Conference foes have played against each other 33 times. The Pittsburgh Steelers own a 17-14-2 series lead. They’ve also won nine of the last 11 meetings over the Detroit Lions.

Their last matchup was a tie in 2021. The Lions haven’t beaten Pittsburgh since 1998. The Steelers have won three of the last four games at Detroit.

Pittsburgh Steelers vs. Detroit Lions Predictions

Aaron Rodgers faces a former longtime rival as the Steelers head to Motown to try and upset one of the league’s best teams. Unfortunately, this Pittsburgh offense won’t find much success in Detroit. Eventually, that strong Steelers defense will wear down and the flood gates will open.

I expect this to be a highly competitive first half before the Lions pour on the points in the second half and run away with the win. Literally, Montgomery and Gibbs will run through Pittsburgh’s defense in the fourth quarter to lead Detroit to a double-digit win.

The calls to bench Rodgers will grow louder as he has multiple turnovers and makes that stupid face he does when he wants to blame everyone else for losing.

Bet: Detroit Lions (-238), Lions -6 (-110)

Cincinnati Bengals vs. Miami Dolphins Odds

TeamMoneylineSpreadTotal
Cincinnati Bengals-122-1.5 (-110)Over 48.5 (-110)
Miami Dolphins+102+1.5 (-110)Under 48.5 (-110)

The Miami Dolphins have owned the Cincinnati Bengals in this rivalry with an 18-8 record in 26 all-time meetings. Yet, the Bengals did win the last matchup which took place in 2022. The Dolphins hold a commanding 9-2 record in home games versus Cincy. The Bengals haven’t won at Miami since 2007.

Cincinnati Bengals vs. Miami Dolphins Predictions

This Sunday Night Football game will have Playoff implications on the line. It should also see plenty of points as well, since neither team has a strong defense.

I like the Over in this matchup as both teams are capable of putting up 30+ points apiece. When it’s all said and done, I fully expect Joe Burrow to outperform Tua Tagovailoa and for the Bengals to win this game by five or more points.

Cincy will continue to score on this Miami defense, but I see the Dolphins offense sputtering late in the game when the pressure is on. This is the exact type of high-stakes game that Miami has lost over the last few years. So, you can expect that trend to continue.

Cincy will keep their hold on one of the AFC Wild Card spots, while the loss will eliminate the Dolphins from the Playoffs and signal changes to come during the offseason.

Bet: Cincinnati Bengals (-122), Bengals -1.5 (-110), Over 48.5 (-110)

San Francisco 49ers vs. Indianapolis Colts Odds

TeamMoneylineSpreadTotal
San Francisco 49ers-162-3 (-110)Over 46.5 (-110)
Indianapolis Colts+136+3 (-110)Under 46.5 (-110)

Surprisingly, it’s the Indianapolis Colts with the series lead at 27-19 over the San Francsico 49ers. Furthermore, the Colts have won five in a row over the 49ers. San Francisco hasn’t beaten the Colts since 2001. That game was at Indy.

The Colts have won two games in a row at home since then, and are 15-7 all-time at home versus the 49ers.

San Francisco 49ers vs. Indianapolis Colts Predictions

Can the NFL apply their flex scheduling for this Monday Night Football game?

How can the schedule makes do such a good job with other matchups in Week 16, but fail so miserable at this MNF contest?

Neither team will make the Playoffs this year, and the Colts will most likely be mathematically eliminated by time this game even takes place. There are a few games on Sunday that should be flexed to this spot.

The 49ers will win this game as they have the better QB, but it won’t matter as they fail to make the Playoffs for the second straight year. The Colts will lose this game because they have inferior QB play and the inferior coaching staff.

Bet: San Francisco 49ers (-162), 49ers -3 (-110)

NFL Week 16 Best Bets

The following is our best bets for Week 16:

  • Denver Broncos (-225)
  • Houston Texans (-198)
  • Cincinnati Bengals (-122)
  • Buffalo Bills (-375)

The Broncos and Texans play at home against vastly inferior teams. Denver will play the hapless Jags and Houston will host the Raiders. I see the defenses of both these teams crushing their opponents and earning the victories. It will be an easy day at the office for both the Houston and Denver offenses.

Over the last few years, Cincy tends to pick things up later in the year as they make their push towards the postseason. This usually means Joe Burrow is torching opposing defense, which is exactly what he’ll do against Miami. Additionally, the Dolphins tend to lose these big matchups late in the season.

Buffalo is playing at Cleveland, which could turn out to be an ugly weather game. However, whether it’s raining, windy, or snowing, the Bills have the superior team and coaching staff compared to the Browns. Buffalo should win this game in a blowout.

If you want to place all four of these picks into an NFL parlay, then you would win $400 on a $100 wager.